Stevens–Johnson syndrome and toxic epidermal necrolysis

Clinical Classification of Cases of Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome, and Erythema Multiforme

1993 • 1,486 citations

Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal Necrolysis

1995 • 1,415 citations

SCORTEN: A Severity-of-Illness Score for Toxic Epidermal Necrolysis

2000 • 1,077 citations

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Assessment of Medication Risks with Emphasis on Recently Marketed Drugs. The EuroSCAR-Study

2007 • 943 citations

Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin

1999 • 867 citations

A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs

2008 • 595 citations

Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel

2007 • 453 citations

Toxic epidermal necrolysis: Effector cells are drug-specific cytotoxic T cells

2004 • 390 citations

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome Are Induced by Soluble Fas Ligand

2003 • 288 citations

Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme

1993 • 283 citations

Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption

2007 • 260 citations

Toxic epidermal necrolysis: current evidence, practical management and future directions

2005 • 248 citations

Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity

2002 • 241 citations

Differential Diagnosis of Severe Cutaneous Drug Eruptions

2003 • 203 citations

Histopathological and epidemiological characteristics of patients with erythema exudativum multiforme major, Stevens-Johnson syndrome and toxic epidermal necrolysis

1996 • 191 citations

Evaluation of the Potential Role of Cytokines in Toxic Epidermal Necrolysis

2004 • 176 citations

Drug-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

2000 • 170 citations

Cutaneous T-cell recruitment in toxic epidermal necrolysis. Further evidence of CD8+ lymphocyte involvement

1993 • 170 citations

Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors

2000 • 166 citations

Expression of cytokines and chemokine receptors in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis

2006 • 128 citations

Histopathological and epidemiological characteristics of patients with erythema exudativum multiforme major, Stevens—Johnson syndrome and toxic epidermal necrolysis

1996 • 120 citations

In vivo dynamics of intraepidermal CD8+ T cells and CD4+ T cells during the evolution of fixed drug eruption

2008 • 114 citations

Immune Mechanisms in Drug Allergy

2006 • 110 citations

Induction of T‐cell‐mediated skin disease specific for antigen transgenically expressed in keratinocytes

2003 • 104 citations

IFN-γ–producing effector CD8+ T cells and IL-10–producing regulatory CD4+ T cells in fixed drug eruption

2003 • 99 citations

Erythema Multiforme and Toxic Epidermal Necrolysis: A Comparative Study

1997 • 98 citations

Anticonvulsant-induced toxic epidermal necrolysis: Monitoring the immunologic response

2000 • 96 citations

Crosstalk Between Keratinocytes and T Lymphocytes via Fas/Fas Ligand Interaction: Modulation by Cytokines

1999 • 95 citations

Uncovering Histologic Criteria With Prognostic Significance in Toxic Epidermal Necrolysis

2005 • 87 citations

Immunoregulatory Effector Cells in Drug-Induced Toxic Epidermal Necrolysis

2000 • 83 citations

Comparison of Reporting of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Association with Selective COX-2 Inhibitors

2005 • 83 citations

Increased interleukin 10, tumor necrosis factor α, and interleukin 6 levels in blister fluid of toxic epidermal necrolysis

2002 • 77 citations

Soluble FAS Ligand: A Discriminating Feature between Drug-Induced Skin Eruptions and Viral Exanthemas

2006 • 75 citations

Treatment Strategies in Toxic Epidermal Necrolysis Syndrome: Where Are We At?

2008 • 60 citations

The CD40/CD40 ligand system is expressed in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum

2005 • 55 citations

Differential cytokine and transcription factor expression in patients with allergic reactions to drugs

2007 • 50 citations

Prevention of toxic epidermal necrolysis by regulatory T cells

2005 • 47 citations

Management of toxic epidermal necrolysis and related syndromes

2008 • 45 citations

Gene Expression Levels of Cytokine Profile and Cytotoxic Markers in Non-Immediate Reactions to Drugs

2002 • 40 citations

Up-regulated perforin expression of CD8+ blood lymphocytes in generalized non-anaphylactic drug eruptions and exacerbated psoriasis.

2000 • 35 citations

Analytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis

2005 • 31 citations

Soluble Fas Ligand: Is It a Critical Mediator of Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome?

2007 • 29 citations

Diagnostic Role of Soluble Fas Ligand Secretion by Peripheral Blood Mononuclear Cells from Patients with Previous Drug-induced Blistering Disease: A Pilot Study

2006 • 14 citations