Treatment Strategies in Toxic Epidermal Necrolysis Syndrome: Where Are We At?

Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal Necrolysis

1995 • 1,415 citations

SCORTEN: A Severity-of-Illness Score for Toxic Epidermal Necrolysis

2000 • 1,077 citations

Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin

1999 • 867 citations

TOXIC EPIDERMAL NECROLYSIS: AN ERUPTION RESEMBLING SCALDING OF THE SKIN.

1956 • 722 citations

Thalidomide Costimulates Primary Human T Lymphocytes, Preferentially Inducing Proliferation, Cytokine Production, and Cytotoxic Responses in the CD8+ Subset

1998 • 576 citations

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

1988 • 564 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

2000 • 477 citations

Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis

1998 • 417 citations

Toxic epidermal necrolysis (Lyell syndrome). Incidence and drug etiology in France, 1981-1985

1990 • 398 citations

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

1991 • 395 citations

Toxic epidermal necrolysis (Lyell syndrome)

1990 • 378 citations

Differences in Metabolism of Sulfonamides Predisposing to Idiosyncratic Toxicity

1986 • 375 citations

Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients

1993 • 372 citations

Intravenous Immunoglobulin Treatment for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

2003 • 371 citations

Treatment of Toxic Epidermal Necrolysis With High-Dose Intravenous Immunoglobulins

2003 • 315 citations

Toxic Epidermal Necrolysis (Lyell Syndrome)

1990 • 300 citations

Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis

1996 • 293 citations

A Multicenter Review of Toxic Epidermal Necrolysis Treated in U.S. Burn Centers at the End of the Twentieth Century

2002 • 289 citations

The Spectrum of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Clinical Classification.

1994 • 282 citations

Analysis of the Acute Ophthalmic Manifestations of the Erythema Multiforme/Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Disease Spectrum

1995 • 274 citations

The Culprit Drugs in 87 Cases of Toxic Epidermal Necrolysis (Lyell's Syndrome)

1987 • 247 citations

Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids

2002 • 237 citations

Analysis of Intravenous Immunoglobulin for the Treatment of Toxic Epidermal Necrolysis Using SCORTEN

2003 • 227 citations

Treatment of Toxic Epidermal Necrolysis with Cyclosporin A

2000 • 206 citations

Toxic Epidermal Necrolysis

1987 • 191 citations

Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis Are Severity Variants of the Same Disease which Differs from Erythema Multiforme

1997 • 185 citations

Drug-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

2000 • 170 citations

Acute disseminated epidermal necrosis types 1, 2, and 3: Study of sixty cases

1985 • 166 citations

Treatment of toxic epidermal necrolysis with intravenous immunoglobulin in children

2002 • 161 citations

A 10-Year Experience With Toxic Epidermal Necrolysis

2000 • 160 citations

Metabolic Predisposition to Cutaneous Adverse Drug Reactions

1995 • 156 citations

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions

2000 • 155 citations

Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis

2001 • 155 citations

Macrophages and tumor necrosis factor alpha in toxic epidermal necrolysis

1994 • 154 citations

Toxic Epidermal Necrolysis: Does Immunoglobulin Make a Difference?

2004 • 153 citations

Efficacy of cyclophosphamide in toxic epidermal necrolysis

1991 • 152 citations

Burn center care for patients with toxic epidermal necrolysis.

1995 • 151 citations

A slow acetylator genotype is a risk factor for sulphonamide-induced toxic epidermal necrolysis and Stevens-Johnson syndrome

1995 • 143 citations

Intravenous Immunoglobulin Does Not Improve Outcome in Toxic Epidermal Necrolysis

2004 • 141 citations

Management of Stevens-Johnson syndrome and toxic epidermal necrolysis in children

1989 • 141 citations

Toxic epidermal necrolysis

1998 • 138 citations

Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis

1999 • 135 citations

Plasmapheresis in Severe Drug-Induced Toxic Epidermal Necrolysis

1985 • 130 citations

Toxic Epidermal Necrolysis Treated with Intravenous High-Dose Immunoglobulins: Our Experience

2001 • 115 citations

Ocular Aftermath of Stevens-Johnson Syndrome

1973 • 110 citations

Macrophages and Tumor Necrosis Factor a in Toxic Epidermal Necrolysis

1994 • 104 citations

Super high flux hemofiltration: a new technique for cytokine removal

2002 • 100 citations

Long-Term Follow-Up of Patients Treated for Toxic Epidermal Necrolysis

2006 • 99 citations

Plasmapheresis in toxic epidermal necrolysis

1997 • 99 citations

Erythema Multiforme and Toxic Epidermal Necrolysis: A Comparative Study

1997 • 98 citations

Episodic Conjunctival Inflammation after Stevens-Johnson Syndrome

1988 • 97 citations

Drug‐Induced Toxic Epidermal Necrolysis Treated with Cyclosporin

1989 • 94 citations

Toxic epidermal necrolysis in a burns centre: A 6-year review

1996 • 90 citations

Outcome of Patients with Toxic Epidermal Necrolysis Syndrome Revisited

2002 • 81 citations

Lack of significant treatment effect of plasma exchange in the treatment of drug-induced toxic epidermal necrolysis?

1999 • 80 citations

SCORTEN Overestimates Mortality in the Setting of a Standardized Treatment Protocol

2006 • 78 citations

Plasma Exchange in Patients with Toxic Epidermal Necrolysis

2002 • 76 citations

Toxic Epidermal Necrolysis

1997 • 74 citations

Characteristics of toxic epidermal necrolysis in patients undergoing long-term glucocorticoid therapy.

1995 • 69 citations

Plasma Exchange (Pe) Treatment in Drug-Induced Toxic Epidermal Necrolysis (Ten)

1991 • 67 citations

Lamotrigine‐induced toxic epidermal necrolysis treated with intravenous cyclosporin: A discussion of pathogenesis and immunosuppressive management

1996 • 67 citations

Management of Severe Toxic Epidermal Necrolysis in Children

1999 • 64 citations

Toxic Epidermal Necrolysis

1975 • 63 citations

Toxic epidermal necrolysis in patients receiving glucocorticosteroids.

1991 • 59 citations

Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin

1998 • 58 citations

Burn Unit Management of Toxic Epidermal Necrolysis

1978 • 58 citations

Treatment of toxic epidermal necrolysis in a pediatric patient with a nanocrystalline silver dressing

2006 • 57 citations

Fifteen cases of toxic epidermal necrolysis (Lyell)

1973 • 57 citations

Toxic epidermal necrolysis: an analysis of referral patterns and steroid usage.

1997 • 57 citations

Cyclophosphamide in the Treatment of Toxic Epidermal Necrolysis

1996 • 54 citations

Toxic Epidermal Necrolysis

1997 • 53 citations

Fatal Toxic Epidermal Necrolysis Following Reexposure to Phenytoin: A Case Report

1983 • 53 citations

Toxic Epidermal Necrolysis

1995 • 53 citations

Characteristics of Toxic Epidermal Necrolysis in Patients Undergoing Long-term Glucocorticoid Therapy

1995 • 49 citations

Toxic epidermal necrolysis treated with cyclosporin and granulocyte colony stimulating factor

1997 • 49 citations

Use of Amnion for the Treatment of Stevens-Johnson Syndrome

1986 • 42 citations

Gene Expression Levels of Cytokine Profile and Cytotoxic Markers in Non-Immediate Reactions to Drugs

2002 • 40 citations

Drug-induced toxic epidermal necrolysis in children

1989 • 38 citations

Would Cyclosporin A Be Beneficial to Mitigate Drug-Induced Toxic Epidermal Necrolysis?

1999 • 38 citations

Toxic Epidermal Necrolysis in a 6‐week‐old Infant

1985 • 34 citations

Toxic epidermal necrolysis: An approach to management using cryopreserved allograft skin

1987 • 33 citations

Ethambutol-Induced Toxic Epidermal Necrolysis

1981 • 33 citations

Recombinant granulocyte colony-stimulating factor in the management of toxic epidermal necrolysis

1996 • 32 citations

Suppressive effects of pentoxifylline on natural killer cell activity.

1992 • 32 citations

Analytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis

2005 • 31 citations

Intensive therapy unit management of toxic epidermal necrolysis: practical aspects

1982 • 29 citations

Pentoxyfylline in toxic epidermal necrolysis and Stevens-Johnson syndrome.

1999 • 28 citations

Outcome of Patients with Toxic Epidermal Necrolysis Syndrome Revisited

2002 • 28 citations

TOXIC EPIDERMAL NECROLYSIS

1978 • 23 citations

Epidemiologic Approaches to the Study of Toxic Epidermal Necrolysis.

1994 • 22 citations

Toxic epidermal necrolysis

1989 • 22 citations

Toxic epidermal necrolysis in a patient with severe aplastic anemia treated with cyclosporin A and G-CSF.

2001 • 22 citations

Treatment of toxic epidermal necrolysis and a review of six cases

1990 • 20 citations

Erythema elevatum diutinum and AIDS: are they related?

1997 • 19 citations

Survival after a Second Episode of Toxic Epidermal Necrolysis

1988 • 19 citations

Toxic epidermal necrolysis successfully treated with cyclosporin. Report of three cases

1997 • 18 citations

Captopril-Induced Toxic Epidermal Necrolysis and Agranulocytosis Successfully Treated With Granulocyte Colony-Stimulating Factor

1999 • 16 citations

TOXIC EPIDERMAL NECROLYSIS

1978 • 15 citations

Acute Life-Threatening Dermatologic Disorders

1981 • 13 citations

Management of toxic epidermal necrolysis with a hydrogel dressing and fluidized-bead bed: report of three cases

1987 • 7 citations

Management of toxic epidermal necrolysis in a 15-year-old girl

2003 • 5 citations