Immune Mechanisms in Drug Allergy

Incidence of Adverse Drug Reactions in Hospitalized Patients

1998 • 4,749 citations

A marker for Stevens–Johnson syndrome

2004 • 1,685 citations

Severe Adverse Cutaneous Reactions to Drugs

1994 • 1,523 citations

Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal Necrolysis

1995 • 1,415 citations

Association between presence of HLA-B*5701, HLA-DR7 , and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

2002 • 1,355 citations

HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

2005 • 1,184 citations

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

2002 • 804 citations

Delayed Drug Hypersensitivity Reactions

2003 • 699 citations

Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982

1986 • 474 citations

A marker for Stevens-Johnson syndrome …: ethnicity matters

2006 • 394 citations

Toxic epidermal necrolysis: Effector cells are drug-specific cytotoxic T cells

2004 • 390 citations

Differences in Metabolism of Sulfonamides Predisposing to Idiosyncratic Toxicity

1986 • 375 citations

Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms.

2001 • 362 citations

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.

1995 • 351 citations

T-cell involvement in drug-induced acute generalized exanthematous pustulosis

2001 • 349 citations

Drug-Induced Cutaneous Reactions

1986 • 341 citations

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

1987 • 320 citations

Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis

1996 • 293 citations

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

1997 • 279 citations

The use of skin testing in the investigation of cutaneous adverse drug reactions

1998 • 258 citations

Association Between Anticonvulsant Hypersensitivity Syndrome and Human Herpesvirus 6 Reactivation and Hypogammaglobulinemia

2004 • 239 citations

Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions

1991 • 215 citations

Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals

2000 • 212 citations

Comprehensive hospital drug monitoring (CHDM): adverse skin reactions, a 20-year survey

1997 • 208 citations

Characterization of drug-specific T cells in lamotrigine hypersensitivity

2003 • 207 citations

Evaluation of the Potential Role of Cytokines in Toxic Epidermal Necrolysis

2004 • 176 citations

Cutaneous T-cell recruitment in toxic epidermal necrolysis. Further evidence of CD8+ lymphocyte involvement

1993 • 170 citations

Metabolic Predisposition to Cutaneous Adverse Drug Reactions

1995 • 156 citations

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions

2000 • 155 citations

T‐cell‐mediated cytotoxicity against keratinocytes in sulfamethoxazol‐induced skin reaction

1998 • 145 citations

Characterization of lidocaine-specific T cells.

1997 • 139 citations

Cutaneous T-Cell Recruitment in Toxic Epidermal Necrolysis

1993 • 128 citations

T-Cell Subsets in Drug-Induced Toxic Epidermal Necrolysis

1991 • 120 citations

Direct Evidence for Interferon-γ Production by Effector-Memory-Type Intraepidermal T Cells Residing at an Effector Site of Immunopathology in Fixed Drug Eruption

2002 • 118 citations

Immunopathology of toxic epidermal necrolysis. Keratinocytes, HLA-DR expression, Langerhans cells, and mononuclear cells: an immunopathologic study of five cases

1992 • 107 citations

Induction of T‐cell‐mediated skin disease specific for antigen transgenically expressed in keratinocytes

2003 • 104 citations

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

2000 • 104 citations

Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity

2002 • 100 citations

IFN-γ–producing effector CD8+ T cells and IL-10–producing regulatory CD4+ T cells in fixed drug eruption

2003 • 99 citations

CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes

2006 • 98 citations

Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients

1994 • 97 citations

Influence of reduced glutathione on the proliferative response of sulfamethoxazole‐specific and sulfamethoxazole‐metabolite‐specific human CD4+ T‐cells

2001 • 94 citations

T Cells Isolated from Positive Epicutaneous Test Reactions to Amoxicillin and Ceftriaxone are Drug Specific and Cytotoxic

2000 • 90 citations

Characterization of Sulfamethoxazole and Sulfamethoxazole Metabolite-Specific T-Cell Responses in Animals and Humans

2003 • 71 citations

Immunopathology of Toxic Epidermal Necrolysis

1992 • 71 citations

Prospective evaluation of risk factors of cutaneous drug reactions to sulfonamides in patients with AIDS

2002 • 70 citations

Minocycline-induced Cell-mediated Hypersensitivity Pneumonitis

1992 • 68 citations

Characterization of Drug-Specific T Cells in Phenobarbital- Induced Eruption

2002 • 65 citations

Prevention of toxic epidermal necrolysis by regulatory T cells

2005 • 47 citations

Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS

2000 • 40 citations

Clinical Pathological Correlation

1985 • 18 citations

TRANSFER OF A DRUG‐INDUCED GENERALIZED RASH IN GUINEA PIGS

1985 • 4 citations