Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

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Severe Adverse Cutaneous Reactions to Drugs

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Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin

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Terminology of Contact Dermatitis

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Clinical Aspects of Immunology

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Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

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Competitive PCR

1992 • 528 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation

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Incidence of adverse drug events and potential adverse drug events

1995 • 408 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity

1997 • 364 citations

Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.

1995 • 351 citations

Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals.

1995 • 196 citations

Extracellular Granzymes A and B in Humans: Detection of Native Species During CTL Responses In Vitro and In Vivo

1998 • 193 citations

Human monocyte inflammatory mediator gene expression is selectively regulated by adherence substrates.

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Infiltration of cytotoxic T cells in drug‐induced cutaneous eruptions

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CYTOTOXIC LYMPHOCYTE GENE EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES CORRELATES WITH REJECTING RENAL ALLOGRAFTS1

1998 • 183 citations

Role of Fas Ligand and Receptor in the Mechanism of T-Cell Depletion in Acquired Immunodeficiency Syndrome: Effect on CD4+ Lymphocyte Depletion and Human Immunodeficiency Virus Replication

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Age-Related Decline of Perforin Expression in Human Cytotoxic T Lymphocytes and Natural Killer Cells

1998 • 129 citations

T cell recognition of penicillin G: Structural features determining antigenic specificity

1996 • 125 citations

Predominance of Epidermal CD8+ T Lymphocytes in Bullous Cutaneous Reactions Caused by β-Lactam Antibiotics

1993 • 120 citations

*Nonimmediate reactions to betalactams: prevalence and role of the different penicillins

1995 • 114 citations

Lymphocyte Activation in Cutaneous Drug Reactions

1995 • 106 citations

Granulysin: a lethal weapon of cytolytic T cells

1999 • 97 citations

Anticonvulsant-induced toxic epidermal necrolysis: Monitoring the immunologic response

2000 • 96 citations

Epidermal Apoptotic Cell Death in Erythema Multiforme and Stevens-Johnson Syndrome

1997 • 83 citations

Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)

1997 • 79 citations

Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction

2000 • 77 citations

A Role for Perforin in Activation-Induced Cell Death

1998 • 58 citations

TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation.

1994 • 37 citations

Defective Expression of Fas Messenger RNA and Fas Receptor on Pulmonary T Cells from Patients with Asthma

1998 • 34 citations

Perforin and granzyme B as markers for acute rejection in heart transplantation

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Expression of the Cutaneous Lymphocyte-Associated Antigen in Circulating T Cells in Drug-Allergic Reactions

1997 • 28 citations

Granzyme B-gene expression: a marker of human lymphocytes “activated” in vitro or in renal allografts

1990 • 21 citations

Erythema multiforme to phenobarbital: Involvement of eosinophils and T cells expressing the skin homing receptor☆☆☆★★★

1997 • 19 citations

High numbers of perforin mRNA expressing CSF cells in multiple sclerosis patients with gadolinium-enhancing brain MRI lesions

1999 • 11 citations

Suppression of tumour necrosis factor-alpha expression in leprosy skin lesions during treatment for leprosy.

1997 • 9 citations

Suppression of tumour necrosis factor-α expression in leprosy skin lesions during treatment for leprosy

1997 • 5 citations

U5 monoclonal antibody identifies a novel lymphocyte surface antigen preferentially expressed in human circulating natural killer cells with high cytotoxic activity

1999 • 3 citations