Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

1996 • 490 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

1997 • 246 citations

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

1997 • 245 citations

The trkA Receptor Mediates Growth Cone Turning toward a Localized Source of Nerve Growth Factor

1997 • 193 citations

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1994 • 184 citations

Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival

1996 • 176 citations

cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner

1997 • 169 citations

Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain

1996 • 154 citations

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase

1996 • 130 citations

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

1992 • 119 citations

Inhibition of p42 and p44 Mitogen‐Activated Protein Kinase Activity by PD98059 Does Not Suppress Nerve Growth Factor‐Induced Survival of Sympathetic Neurones

1996 • 100 citations

Comparison Between the Timing of JNK activation, c‐Jun Phosphorylation, and Onset of Death Commitment in Sympathetic Neurones

1997 • 100 citations

Neutralizing Anti‐p21^ras Fabs Suppress Rat Sympathetic Neuron Survival Induced by NGF, LIF, CNTF and cAMP

1995 • 89 citations

Developmental Regulation of Apoptosis in Dorsal Root Ganglion Neurons

1998 • 74 citations

Activation of p44 and p42 MAP Kinases is not Essential for the Survival of Rat Sympathetic Neurons

1995 • 68 citations

Identification and cDNA Cloning of a Novel Mammalian C2 Domain-Containing Phosphoinositide 3-Kinase, HsC2-PI3K

1997 • 66 citations

In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-βNGF

1997 • 64 citations

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons.

1990 • 53 citations

Phosphotyrosine Residues in the Nerve‐Growth‐Factor Receptor (Trk‐A)

1995 • 50 citations

Signalling events regulating the retrograde axonal transport of 125I−βNerve growth factor in vivo

1998 • 42 citations

Identification of Four Novel Human Phosphoinositide 3-Kinases Defines a Multi-isoform Subfamily

1997 • 40 citations

Nerve Growth Factor is Required for Induction of c‐Fos Immunoreactivity by Serum, Depolarization, Cyclic AMP or Trauma in Cultured Rat Sympathetic Neurons

1991 • 25 citations

Wortmannin blocks goldfish retinal phosphatidylinositol 3-kinase and neurite outgrowth.

1997 • 15 citations

Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28

1997 • 14 citations