Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers.

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

1990 • 629 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions

1985 • 413 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

1988 • 362 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.

1991 • 231 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

1988 • 175 citations

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

1992 • 147 citations

Hypersensitive site 4 of the human β globin locus control region

1991 • 141 citations

Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein

1990 • 140 citations

In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer.

1987 • 127 citations

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

1989 • 122 citations

Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.

1991 • 121 citations

Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

1990 • 105 citations

In vivo protein-DNA interactions at the beta-globin gene locus.

1991 • 97 citations

Recombinant 43-kDa USF binds to DNA and activates transcription in a manner indistinguishable from that of natural 43/44-kDa USF.

1991 • 88 citations

Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice.

1992 • 85 citations

A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation

1990 • 79 citations

Protein-DNA interactions in vivo of an erythroid-specific, human beta-globin locus enhancer.

1991 • 71 citations

Recombinant 43-kDa USF Binds to DNA and Activates Transcription in a Manner Indistinguishable from That of Natural 43/44-kDa USF

1991 • 28 citations