On the biological role of histone acetylation

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

1964 • 2,410 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.

1979 • 1,532 citations

Structure of Chromatin

1977 • 1,276 citations

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Sodium butyrate inhibits histone deacetylation in cultured cells

1978 • 1,008 citations

Nucleosome Structure

1980 • 923 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

1981 • 808 citations

n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells

1977 • 787 citations

Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA

1978 • 763 citations

Structure of nucleosome core particles of chromatin

1977 • 746 citations

The effect of sodium butyrate on histone modification

1978 • 680 citations

Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones

1987 • 609 citations

Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones

1978 • 583 citations

Histones

1979 • 538 citations

Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

1976 • 523 citations

Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences.

1978 • 459 citations

The presence of acetyl groups in histones

1963 • 458 citations

Calf and Pea Histone IV

1969 • 451 citations

RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.

1966 • 445 citations

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast

1988 • 441 citations

Processing of Newly Synthesized Histone Molecules

1975 • 434 citations

Chromatin

1982 • 399 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II

1987 • 394 citations

Calf and Pea Histone IV

1969 • 393 citations

Sequence-Specific Packaging of DNA in Human Sperm Chromatin

1987 • 384 citations

Transcriptionally active chromatin

1984 • 361 citations

Assembly of SV40 chromatin in a cell-free system from Xenopus eggs

1977 • 358 citations

Transcription-driven supercoiling of DNA: Direct biochemical evidence from in vitro studies

1989 • 357 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

Different accessibilities in chromatin to histone acetylase.

1979 • 340 citations

A low resolution structure for the histone core of the nucleosome

1980 • 309 citations

Structure of chromatin containing extensively acetylated H3 and H4

1978 • 290 citations

Structure of Transcribing Chromatin

1980 • 281 citations

Evidence that approximately eighty per cent of the soluble proteins from Ehrlich ascites cells are Nalpha-acetylated.

1976 • 274 citations

Two complexes that contain histones are required for nucleosome assembly in vitro: Role of nucleoplasmin and N1 in Xenopus egg extracts

1987 • 271 citations

Structure of the 3000Å chromatin filament: X-ray diffraction from oriented samples

1985 • 267 citations

Participation of core histone "tails" in the stabilization of the chromatin solenoid.

1982 • 264 citations

Supercoiling of intracellular DNA can occur in eukaryotic cells

1988 • 263 citations

The regulation of yeast mating-type chromatin structure by SIR: An action at a distance affecting both transcription and transposition

1982 • 257 citations

Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast.

1986 • 254 citations

Assembly of nucleosomes: the reaction involving X. laevis nucleoplasmin

1980 • 248 citations

Biochemical evidence of variability in the DNA repeat length in the chromatin of higher eukaryotes.

1976 • 240 citations

More histone structures

1979 • 238 citations

Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.

1988 • 226 citations

Effects of histone H4 depletion on the cell cycle and transcription of Saccharomyces cerevisiae.

1988 • 225 citations

Eukaryotic RNA polymerase II binds to nucleosome cores from transcribed genes

1983 • 224 citations

Basic nuclear proteins in testicular cells and ejaculated spermatozoa in man

1978 • 213 citations

Histone hyperacetylation: its effects on nucleosome conformation and stability

1986 • 211 citations

Co-existence of two different types of soluble histone complexes in nuclei of Xenopus laevis oocytes.

1985 • 210 citations

Dissection of Chromosome Structure with Trypsin and Nucleases

1974 • 201 citations

Modifications to histones immediately after synthesis

1976 • 201 citations

Structure of the 30 nm chromatin fiber

1986 • 190 citations

Modification of Histones during Spermiogenesis in Trout: A Molecular Mechanism for Altering Histone Binding to DNA

1970 • 187 citations

Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly

1988 • 186 citations

Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions.

1981 • 179 citations

An acidic protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei

1980 • 169 citations

Histone H2B repression causes cell-cycle-specific arrest in yeast: Effects on chromosomal segregation, replication, and transcription

1987 • 164 citations

Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences

1987 • 164 citations

Developmental changes in chromosomal composition and template activity during spermatogenesis in trout testis

1969 • 161 citations

Soluble acidic complexes containing histones H3 and H4 in nuclei of Xenopus laevis oocytes

1982 • 158 citations

Structural Analysis of the Glycine-rich, Arginine-rich Histone

1969 • 157 citations

Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities.

1978 • 156 citations

Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in HMG-1.

1979 • 154 citations

Regulation of the higher-order structure of chromatin by histones H1 and H5.

1981 • 152 citations

A comparison of the structure of chicken erythrocytef and chicken liver chromatin

1976 • 148 citations

A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it

1987 • 148 citations

DNA associated with hyperacetylated histone is preferentially digested by DNase I

1978 • 147 citations

Changing patterns of histone acetylation and RNA synthesis in regeneration of the liver.

1968 • 147 citations

Acetylated histone H4 is preferentially associated with template-active chromatin.

1978 • 146 citations

High‐Resolution Proton‐Magnetic‐Resonance Studies of Chromatin Core Particles

1978 • 146 citations

Nonrandom utilization of acetylation sites in histones isolated from Tetrahymena. Evidence for functionally distinct H4 acetylation sites.

1986 • 142 citations

The nucleosome repeat length increases during erythropoiesis in the chick

1978 • 138 citations

Small angle neutron scattering studies of chromatin subunits in solution

1977 • 138 citations

Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena.

1985 • 137 citations

Effect of histone acetylation on structure and in vitro transcription of chromatin

1978 • 132 citations

Identification of domains involved in nuclear uptake and histone binding of protein N1 of Xenopus laevis.

1988 • 132 citations

A major soluble acidic protein located in nuclei of diverse vertebrate species

1980 • 131 citations

Rapid and reversible changes in nucleosome structure accompany the activation, repression, and superinduction of murine fibroblast protooncogenes c-fos and c-myc.

1987 • 125 citations

The structure of the chromatin core particle in solution

1977 • 123 citations

A low resolution model for the chromatin core particle by neutron scattering

1977 • 121 citations

Folding of DNA by histones which lack their NH2-terminal regions.

1978 • 120 citations

Localization of the sites along nucleosome DNA which interact with NH2-terminal histone regions.

1977 • 119 citations

Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones

1980 • 118 citations

Properties of active nucleosomes as revealed by HMG 14 and 17 chromatography

1982 • 109 citations

Acetylation of histones in nucleosomes

1982 • 108 citations

Rat liver HMG1: a physiological nucleosome assembly factor.

1984 • 107 citations

Hyperacetylation of histone H4 promotes chromatin decondensation prior to histone replacement by protamines during spermatogenesis in rainbow trout

1984 • 103 citations

Chicken erythrocyte polynucleosomes which are soluble at physiological ionic strength and contain linker histones are highly enriched hi β-globin gene sequences

1987 • 99 citations

Hyperacetylation of histone H4 correlates with the terminal, transcriptionally inactive stages of spermatogenesis in rainbow trout

1982 • 98 citations

The effect of histone hyperacetylation on the nuclease sensitivity and the solubility of chromatin.

1981 • 97 citations

Proteolytic Digestion Studies of Chromatin Core‐Histone Structure

1980 • 96 citations

Changes in Histone Acetyl Content and in Nuclear Non-Histone Protein Composition of Avian Erythroid Cells at Different Stages of Maturation

1974 • 95 citations

Transformation of Trout Testis Chromatin

1971 • 95 citations

Structure of transcriptionally-active chromatin subunits

1977 • 93 citations

Factors affecting nucleosome disassembly by protamines in vitro. Histone hyperacetylation and chromatin structure, time dependence, and the size of the sperm nuclear proteins.

1987 • 93 citations

Nucleosomal Particles Open as the Histone Core Becomes Hyperacetylated

1983 • 93 citations

Hyperacetylation of histone H4 in rat testis spermatids

1984 • 91 citations

Histone H4 hyperacetylation and rapid turnover of its acetyl groups in transcriptionally inactive rooster testis spermatids

1982 • 89 citations

Yeast histone H2A and H2B amino termini have interchangeable functions

1986 • 88 citations

Xenopus nucleoplasmin: egg vs. oocyte

1986 • 86 citations

Effect of Acetylation on the Binding of N-Terminal Peptides of Histone H4 to DNA

1982 • 85 citations

STUDIES ON HISTONE FRACTION F2A1 IN MACRO- AND MICRONUCLEI OF TETRAHYMENA PYRIFORMIS

1973 • 84 citations

Histone hyperacetylation has little effect on the higher order folding of chromatin

1983 • 83 citations

Regulation of histone acetylation in Tetrahymena macro- and micronuclei.

1982 • 80 citations

A comparison of the turnover of alpha-N-acetylated and nonacetylated mouse L-cell proteins.

1979 • 80 citations

Histone modifications in the yeast S. cerevisiae

1981 • 79 citations

Comparative studies of histone acetylation in nucleosomes, nuclei, and intact cells. Evidence for special factors which modify acetylase action.

1980 • 79 citations

Modulation of the Nucleosome Structure by Histone Acetylation

1980 • 76 citations

Chromatin core particle unfolding induced by tryptic cleavage of histones

1977 • 75 citations

Massive phosphorylation distinguishes Xenopus laevis nucleoplasmin isolated from oocytes or unfertilized eggs

1986 • 75 citations

Yeast may not contain histone H1: the only known ‘histone H1-like’ protein inSaccharomyces cerevisiaeis a mitochondrial protein

1984 • 75 citations

Histone acetylation in chicken erythrocytes. Rates of acetylation and evidence that histones in both active and potentially active chromatin are rapidly modified

1988 • 75 citations

Hyperacetylation of core histones does not cause unfolding of nucleosomes. Neutron scatter data accords with disc shape of the nucleosome.

1986 • 75 citations

On the displacement of histones from DNA by transcription

1988 • 75 citations

X-ray studies on “Native” chromatin

1977 • 73 citations

Yeast histone H2B containing large amino terminus deletions can function in vivo

1983 • 73 citations

Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in high mobility group proteins 14 and 17.

1981 • 71 citations

Calcium-dependent phosphorylation of histone H3 in butyrate-treated HeLa cells

1980 • 70 citations

Histone-specific acetyltransferases from calf thymus. Isolation, properties, and substrate specificity of three different enzymes

1980 • 70 citations

Histone H4 from cuttlefish testis is sequentially acetylated. Comparison with acetylation of calf thymus histone H4.

1987 • 70 citations

Yeast chromatin is uniformly digested by DNase-I.

1979 • 69 citations

Alterations in chromatin structure during early sea urchin embryogenesis.

1981 • 68 citations

Extensive purification of histone acetylase A, the major histone N-acetyl transferase activity detected in mammalian cell nuclei.

1980 • 67 citations

Synthesis, Acetylation, and Phosphorylation of Histone IV and Its Binding to DNA During Spermatogenesis in Trout

1972 • 65 citations

Cellular protein synthesis and inhibition of cell division are independent of butyrate-induced histone hyperacetylation

1979 • 65 citations

From macromolecules to biological assemblies

1983 • 63 citations

Distribution of high mobility group proteins among domains of trout testis chromatin differing in their susceptibility to micrococcal nuclease.

1980 • 59 citations

Trout Testis Cells

1972 • 58 citations

A single histone acetyltransferase from Tetrahymena macronuclei catalyzes deposition-related acetylation of free histones and transcription-related acetylation of nucleosomal histones.

1987 • 58 citations

Histone acetylation in baker's yeast. Maintenance of the hyperacetylated configuration in log phase protoplasts.

1982 • 56 citations

Patterns of histone acetylation in Physarum polycephalum

1984 • 55 citations

Thermal Denaturation Studies of Acetylated Nucleosomes and Oligonucleosmes

1982 • 55 citations

Isolation, identification, and characterization of histones from plasmodia of the true slime mold Physarum polycephalum using extraction with guanidine hydrochloride

1983 • 55 citations

The modification of stored histones H3 and H4 during the oogenesis and early development of Xenopus laevis

1979 • 54 citations

Levels of histone H4 diacetylation decrease dramatically during sea urchin embryonic development and correlate with cell doubling rate.

1984 • 51 citations

The separation of transcriptionally engaged genes.

1988 • 51 citations

Immunochemical detection of changes in chromatin subunits induced by histone H4 acetylation.

1982 • 49 citations

Histone acetylation and hormone action. Early effects of oestradiol-17β on histone acetylation in rat uterus

1972 • 49 citations

Sodium butyrate induced structural changes in HeLa cell chromatin

1982 • 48 citations

Transcriptionally active mononucleosomes from trout testis are heterogeneous in composition.

1980 • 47 citations

Amino-acid sequence of Tetrahymena histone H4 differs from that of higher eukaryotes.

1979 • 47 citations

Histone acetylation by cell-free preparations from rat uterus: In vitro stimulation by estradiol-17β

1968 • 47 citations

Accessibility of newly synthesized chromatin to histone acetylase.

1982 • 46 citations

Histone acetylase from Drosophila melanogaster specific for H4.

1981 • 46 citations

Neutron‐scattering studies of the structure of chromatin core particles in solution

1981 • 45 citations

Extensive purification and characterization of chromatin-bound histone acetyltransferase from Saccharomyces cerevisiae.

1984 • 45 citations

The use of DNA-cellulose for analyzing histone-DNA interactions. Discovery of nucleosome-like histone binding to single-stranded DNA.

1979 • 41 citations

Cell cycle-dependent changes in conformation and composition of nucleosomes containing human histone gene sequences

1987 • 41 citations

A chromatin core particle obtained by selective cleavage of histones by clostripain.

1986 • 40 citations

DNase I sensitive chromatin is enriched in the acetylated species of histone H4

1980 • 39 citations

DNA wrapping in nucleosomes. The linking number problem re-examined

1980 • 38 citations

The structure of chromatin containing DNA complementary to 19 S and 26 S ribosomal RNA in active and inactive stages of Physarum polycephalum

1978 • 38 citations

Hyperacetylated histones facilitate chromatin assemblyin vitro

1985 • 37 citations

Histone deacetylase. Association with a nuclease resistant, high molecular weight fraction of HeLa cell chromatin.

1983 • 37 citations

Structural studies of acetylated and control inner core histones

1987 • 35 citations

Purification of a novel, nucleoplasmin-like protein from somatic nuclei.

1987 • 35 citations

Differential conservation of histone 2A variants between mammals and sea urchins.

1982 • 34 citations

Acetylation of Nucleosomal Histones in vitro

1980 • 32 citations

Changes in histone acetylation and RNA synthesis in the spleen of polycythemic mouse after erythropoietin injection

1969 • 32 citations

Histone H1 Involvement in the Structure of the Chromosome Fiber

1978 • 30 citations

Immunological evidence for the existence of H1‐like histone in yeast

1987 • 29 citations

Modification of histones immediately following synthesis

1979 • 29 citations

A correlation between nucleosome spacer region susceptibility to DNase 1 and histone acetylation

1979 • 29 citations

Histone acetylation in replication and transcription: Turnover at specific acetylation sites in histone H4 from Physarum polycephalum

1986 • 28 citations

Acetylation and methylation sites in histone H4 from Physarum polycephalum

1983 • 27 citations

Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney

1973 • 27 citations

Only a small fraction of avian erythrocyte histone is involved in ongoing acetylation

1981 • 27 citations

Acetylation of rat testis histones H2B and TH2B

1984 • 25 citations

Purification and Properties of a Histone Acetyltransferase from Artemia salina, Highly Efficient with H1 Histone

1979 • 24 citations

Histone acetylation in chicken erythrocytes. Estimation of the percentage of sites actively modified

1986 • 23 citations

Immunological identification of the karyophilic, histone-binding proteins N1 and N2 in somatic cells and oocytes of diverse amphibia

1985 • 22 citations

The Extent of Histone Acetylation Induced by Butyrate and the Turnover of Acetyl Groups Depends on the Nature of the Cell Line

1981 • 22 citations

Acetylation of histone H4 in chicken erythrocyte and cuttle‐fish testis chromatin

1981 • 19 citations

Structure of hyperacetylated chromatin: light scattering and flow linear dichroism study

1986 • 18 citations

Human Spleen Histone H3. Isolation and Amino Acid Sequence1

1981 • 18 citations

Rapid modulation by progesterone and tamoxifen of estradiol effects on nuclear histone acetylation in the uterus of the fetal guinea pig

1983 • 17 citations

Modification of histones during the mitotic and meiotic cycle of yeast

1982 • 17 citations

The isolation of HTC variant cells which can replicate in butyrate. Changes in histone acetylation and tyrosine aminotransferase induction.

1985 • 17 citations

Transient Unfolding of Trypsin‐Digested Chromatin Core Particles

1982 • 16 citations

Histone acetylation and the DNAse I sensitivity of the Tetrahymena ribosomal gene

1982 • 15 citations

Isolation and Partial Charcterization of Three Histone-Specific Acetyltransferases form Artemia

1983 • 14 citations

Epidermal growth factor enhances acetylation of nuclear proteins in cultured human liver cells

1983 • 13 citations

Histone deacetylase from HeLa cells: properties of the high molecular weight complex

1983 • 12 citations

The primary structure of histone H2A from the nematode Caenorhabditis elegans

1987 • 10 citations

Doxorubicin induces the acetylation of histone Hl in a human colon cancer cell line (LoVo/DX) selected for resistance to the drug, but not in the sensitive parental line (LoVo)

1988 • 9 citations

Increased acetylation of histones at an early stage of oestradiol-mediated gene activation in the liver of immature chicks

1986 • 8 citations

Transcription of chemically acetylated chromatin with homologous RNA polymerase B

1984 • 7 citations

Effects of gene modulators on the acetylation of chromosomal proteins of rat liver slices

1981 • 3 citations