Differential Role of the Transcription Factor NF-κB in Selection and Survival of CD4+ and CD8+ Thymocytes

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

1998 • 643 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Positive Selection of Thymocytes

1995 • 604 citations

Negative selection — clearing out the bad apples from the T-cell repertoire

2003 • 494 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Haematopoietic cell-fate decisions, chromatin regulation and ikaros

2002 • 324 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling

2004 • 306 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

Characterization of the ovalbumin‐specific TCR transgenic line OT‐I: MHC elements for positive and negative selection

2000 • 279 citations

MOLECULAR GENETICS OF T CELL DEVELOPMENT

2004 • 262 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1995 • 229 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Mature T Cells Depend on Signaling through the IKK Complex

2003 • 210 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

2001 • 190 citations

Thymic selection: a matter of life and death

1992 • 184 citations

Functions of E2A-HEB Heterodimers in T-Cell Development Revealed by a Dominant Negative Mutation of HEB

2000 • 180 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

1999 • 157 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

Tec Family Kinases Modulate Thresholds for Thymocyte Development and Selection

2000 • 131 citations

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

2000 • 123 citations

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

2005 • 123 citations

Cellular and molecular events during early thymus development

2006 • 117 citations

T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis

2008 • 111 citations

Epigenetic gene silencing by Runx proteins

2004 • 63 citations

NF-κB Is Required for the Positive Selection of CD8+ Thymocytes

2000 • 60 citations

Identification of a Developmentally Regulated Phase of Postselection Expansion Driven by Thymic Epithelium

1998 • 46 citations

Proteasome regulation of Fas ligand cytotoxicity

1997 • 44 citations

Opening a Window on Thymic Positive Selection: Developmental Changes in the Influence of Cosignaling by Integrins and CD28 on Selection Events Induced by TCR Engagement

2000 • 43 citations

Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping

2008 • 42 citations

Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes.

1995 • 41 citations

Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-κB/Rel

2001 • 37 citations

Generation of mature T cell populations in the thymus: CD4 or CD8 down‐regulation occurs at different stages of thymocyte differentiation

1994 • 36 citations

CD4/CD8 lineage commitment: light at the end of the tunnel?

2006 • 33 citations

A Role for Accessibility to Self-Peptide-Self-MHC Complexes in Intrathymic Negative Selection

2001 • 33 citations

Cutting Edge: Identification of the Targets of Clonal Deletion in an Unmanipulated Thymus

2003 • 29 citations

Lineage-specific differences among CD8+ T cells in their dependence of NF-κB/Rel signaling

1999 • 26 citations