Molecular analysis of the physiological and pathophysiological role of ?4-integrins

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

A tissue-specific endothelial cell molecule involved in lymphocyte homing

1988 • 725 citations

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.

1995 • 716 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

Physiological and Molecular Mechanisms of Lymphocyte Homing

1992 • 655 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis.

1991 • 628 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin.

1993 • 455 citations

Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells

1992 • 417 citations

Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis

1992 • 404 citations

A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture.

1991 • 399 citations

Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma.

1992 • 388 citations

MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1

1993 • 383 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

The pathophysiologic role of alpha 4 integrins in vivo.

1994 • 380 citations

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine

1991 • 362 citations

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.

1994 • 350 citations

Structure of the Integrin VLA‐4 and its Cell‐Cell and Cell‐Matrix Adhesion Functions

1990 • 345 citations

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering

1992 • 334 citations

Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody.

1993 • 327 citations

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

1994 • 314 citations

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

1994 • 312 citations

Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

1992 • 307 citations

Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110

1990 • 295 citations

Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.

1991 • 293 citations

Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways.

1991 • 291 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1.

1993 • 266 citations

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

1993 • 254 citations

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.

1994 • 250 citations

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

1991 • 244 citations

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

1990 • 244 citations

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

1991 • 234 citations

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells.

1991 • 234 citations

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.

1990 • 224 citations

Expression of the integrin $alpha;4$beta;1 on melanoma cells can inhibit the invasive stage of metastasis formation

1994 • 221 citations

Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction.

1992 • 218 citations

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium.

1993 • 218 citations

VLA‐3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization

1986 • 214 citations

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

1994 • 213 citations

Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo.

1991 • 211 citations

Integrin-mediated cell adhesion: the extracellular face.

1994 • 204 citations

Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.

1991 • 203 citations

L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo.

1994 • 199 citations

Physiology of Thrombospondin

1990 • 195 citations

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.

1991 • 189 citations

Control of lymphocyte homing

1994 • 170 citations

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions.

1994 • 168 citations

Alpha 4 beta 1 and alpha 5 beta 1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34+ cells to fibronectin in an activation-dependent way

1993 • 168 citations

Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.

1994 • 165 citations

Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1.

1992 • 163 citations

VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes.

1993 • 163 citations

Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways.

1994 • 161 citations

Very late activation antigen 4-vascular cell adhesion molecule 1 interaction is involved in the formation of erythroblastic islands.

1995 • 160 citations

Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.

1994 • 154 citations

CD9 antigen is an accessory subunit of the VLA integrin complexes

1994 • 151 citations

Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium.

1992 • 150 citations

Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells

1993 • 146 citations

Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing.

1992 • 145 citations

Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.

1992 • 143 citations

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1)

1994 • 142 citations

CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin.

1994 • 136 citations

Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1.

1991 • 134 citations

Signaling by vascular cell adhesion molecule‐1 (VCAM‐1) through VLA‐4 promotes CD3‐dependent T cell proliferation

1991 • 131 citations

Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro.

1994 • 128 citations

Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.

1993 • 128 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

Activated T-cell adhesion to thrombospondin is mediated by the alpha 4 beta 1 (VLA-4) and alpha 5 beta 1 (VLA-5) integrins.

1993 • 122 citations

Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice.

1994 • 121 citations

Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin.

1993 • 117 citations

Expanding Roles for α4 Integrin and its Ligands in Development

1994 • 116 citations

Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.

1991 • 113 citations

Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin

1994 • 109 citations

The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.

1994 • 104 citations

The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat.

1994 • 104 citations

Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms.

1995 • 101 citations

Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin.

1993 • 100 citations

Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.

1993 • 98 citations

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.

1994 • 96 citations

Monoclonal antibodies to the integrin α−4 subunit inhibit the murine contact hypersensitivity response

1993 • 95 citations

A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice.

1994 • 95 citations

Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.

1994 • 93 citations

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

1993 • 91 citations

VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin.

1993 • 90 citations

T lymphocyte migration to arthritic joints and dermal inflammation in the rat: Differing migration patterns and the involvement of VLA-4

1991 • 86 citations

Dual inhibition of VLA-4 and LFA-1 maximally inhibits cutaneous delayed-type hypersensitivity-induced inflammation.

1993 • 86 citations

Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies.

1994 • 85 citations

Distinct binding specificities of integrins α4β7 (LPAM-1), α4β1 (VLA-4), and αIELβ7

1994 • 83 citations

Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.

1992 • 82 citations

Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain.

1994 • 81 citations

The α4β1/VCAM-1 adhesion pathway in physiology and disease

1993 • 80 citations

Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion.

1994 • 79 citations

Stimulation of protein tyrosine phosphorylation in human B cells after ligation of the beta 1 integrin VLA-4.

1993 • 70 citations

Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial beta 1 integrin ligand invasin.

1993 • 69 citations

Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin.

1993 • 58 citations

Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to alpha 4 beta 1.

1994 • 57 citations

The heat-stable antigen can alter very late antigen 4-mediated adhesion.

1994 • 56 citations

Protection Against Adoptive Transfer of Autoimmune Diabetes Mediated Through Very Late Antigen-4 Integrin

1994 • 49 citations

Lymphocyte Surface Antigen L25 Is a Member of the Integrin Receptor Superfamily

1989 • 49 citations

α_Eβ₇ and α₄β₇ integrins associated with intraepithelial and mucosal homing, are expressed on macrophages

1995 • 49 citations

Coordinate expression of β1 and β2 integrin “activation” epitopes during T cell responses in secondary lymphoid tissue

1993 • 45 citations

Differential expression in rheumatoid synovium and synovial fluid of alpha 4 beta 7 integrin. A novel receptor for fibronectin and vascular cell adhesion molecule-1.

1993 • 44 citations

Expression of a protective intestinal immune response can be inhibited at three distinct sites by treatment with anti-alpha 4 integrin.

1993 • 41 citations

Differential Regulation of α4 Integrin-dependent Binding to Domains 1 and 4 of Vascular Cell Adhesion Molecule-1

1995 • 40 citations

Activation Dependent and Independent VLA-4 Binding Sites on Vascular Cell Adhesion Molecule-1

1994 • 39 citations

Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrin.

1994 • 32 citations

Alpha 4/180, a novel form of the integrin alpha 4 subunit.

1993 • 26 citations

The Contributions of Integrins to Leukocyte Infiltration in Inflamed Tissues

1993 • 13 citations