Yeast KEX2 Endopeptidase Correctly Cleaves a Neuroendocrine Prohormone in Mammalian Cells

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Structure and Biosynthesis of Pro-Adrenocorticotropin/Endorphin and Related Peptides*

1980 • 859 citations

[16] Protein determination in membrane and lipoprotein samples: Manual and automated procedures

1981 • 765 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

1984 • 477 citations

Brain Peptides: What, Where, And Why?

1983 • 470 citations

PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS*

1980 • 461 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

PRODUCTION OF BOTH PROLACTIN AND GROWTH HORMONE BY CLONAL STRAINS OF RAT PITUITARY TUMOR CELLS

1970 • 342 citations

Characterization of a common precursor to corticotropin and beta-lipotropin: cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule.

1977 • 337 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides

1983 • 295 citations

Protein Localization and Membrane Traffic in Yeast

1985 • 267 citations

Secretion and processing of insulin precursors in yeast.

1986 • 227 citations

Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells.

1986 • 220 citations

Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA.

1983 • 207 citations

[63] Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone

1981 • 170 citations

Protein secretion from Saccharomyces cerevisiae directed by the prepro-alpha-factor leader region.

1986 • 144 citations

Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent.

1987 • 124 citations

Hormone processing and membrane-bound proteinases in yeast.

1985 • 114 citations

Hormonal Induction of Secretory Granules in a Pituitary Tumor Cell Line*

1986 • 107 citations

Cathepsin B-related proteases in the insulin secretory granule.

1984 • 89 citations

Yeast KEX2 Protease Has the Properties of a Human Proalbumin Converting Enzyme

1987 • 85 citations

Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex.

1987 • 84 citations

Expression and Cell Type—Specific Processing of Human Preproenkephalin with a Vaccinia Recombinant

1986 • 81 citations

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules

1987 • 69 citations

Further Characterization of an Enkephalin‐Generating Enzyme from Adrenal Medullary Chromaffin Granules

1984 • 66 citations

Processing and metabolism of neuropeptides.

1986 • 57 citations

A novel serine protease (IRCM-serine protease 1) from porcine neurointermediate and anterior pituitary lobes. Isolation, polypeptide chain structure, inhibitor sensitivity, and substrate specificity with fluorogenic peptide substrates.

1986 • 55 citations

A membrane-bound, calcium-dependent protease in yeast α-cell cleaving on the carboxyl side of paired basic residues

1987 • 55 citations

Gene Transfer Techniques to Study Neuropeptide Processing

1988 • 55 citations

Role of glandular kallikreins as growth factor processing enzymes: Structural and evolutionary considerations

1987 • 53 citations

Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving prooxytocin/neurophysin peptides at the basic amino acid doublet

1987 • 44 citations

Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins.

1984 • 37 citations

Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme.

1986 • 36 citations

[20] Use of vaccinia virus as a neuropeptide expression vector

1986 • 31 citations

In VitroProcessing of Proopiocortin by Membrane-Associated and Soluble Converting Enzyme Activities from Rat Intermediate Lobe Secretory Granules

1984 • 28 citations

Induction of differentiation increases Met5-enkephalin and Leu5- enkephalin content in NG108-15 hybrid cells: an immunocytochemical and biochemical analysis

1983 • 26 citations

Post-translational processing of pro-opiomelanocortin (POMC)-derived peptides during fetal monkey pituitary development

1988 • 23 citations

Some characteristics of hormone (pheromone) processing enzymes in yeast

1987 • 21 citations

Post-translational processing of pro-opiomelanocortin (POMC)-derived peptides during fetal monkey pituitary development

1988 • 21 citations

Comparison of patterns of prolactin release in GH4C1 cells and primary pituitary cultures

1985 • 19 citations

Cell-type specific processing of neuroendocrine precursor proteins using vaccinia recombinants

1988 • 16 citations

Chapter 8 Glycosylation Steps Involved in Processing of Pro-Corticotropin-Endorphin in Mouse Pituitary Tumor Cells

1981 • 6 citations