PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS*

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

Proteases and biological control

1976 • 1,380 citations

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

1975 • 1,175 citations

Common precursor to corticotropins and endorphins

1977 • 1,106 citations

LYSOSOME FUNCTION IN THE REGULATION OF THE SECRETORY PROCESS IN CELLS OF THE ANTERIOR PITUITARY GLAND

1966 • 951 citations

INTRACELLULAR TRANSPORT OF SECRETORY PROTEINS IN THE PANCREATIC EXOCRINE CELL

1967 • 841 citations

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

1978 • 791 citations

INTRACELLULAR TRANSPORT OF SECRETORY PROTEINS IN THE PANCREATIC EXOCRINE CELL

1967 • 746 citations

Insulin Biosynthesis: Evidence for a Precursor

1967 • 699 citations

Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone

1977 • 532 citations

A bacterial clone synthesizing proinsulin.

1978 • 515 citations

Current topics in Microbiology and Immunology

1976 • 463 citations

The Outer Membrane Proteins of Gram-Negative Bacteria: Biosynthesis, Assembly, and Functions

1978 • 457 citations

Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast.

1979 • 455 citations

Synthesis and transport of the small subunit of chloroplast ribulose bisphosphate carboxylase

1978 • 429 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis

1979 • 408 citations

INTRACELLULAR TRANSPORT OF SECRETORY PROTEINS IN THE PANCREATIC EXOCRINE CELL

1968 • 376 citations

Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane protein

1977 • 366 citations

In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii.

1977 • 332 citations

Porcine Proinsulin: Characterization and Amino Acid Sequence

1968 • 318 citations

Ovalbumin: a secreted protein without a transient hydrophobic leader sequence.

1978 • 309 citations

Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells.

1976 • 284 citations

Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination.

1976 • 279 citations

Homology in amino-terminal sequence of precursors to pancreatic secretory proteins.

1975 • 272 citations

A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function.

1978 • 266 citations

Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity.

1977 • 259 citations

The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures.

1979 • 255 citations

α-Neo-endorphin: A “big” leu-enkephalin with potent opiate activity from porcine hypothalami

1979 • 229 citations

Chicken ovalbumin contains an internal signal sequence

1979 • 216 citations

Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes.

1978 • 213 citations

Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein.

1978 • 209 citations

Studies on the Conversion of Proinsulin to Insulin

1971 • 206 citations

Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells

1978 • 198 citations

Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein

1978 • 187 citations

Cell-free synthesis of fish preproinsulin, and processing by heterologous mammalian microsomal membranes.

1977 • 182 citations

Proteolytic processing in the biosynthesis of insulin and other proteins.

1974 • 172 citations

Synthesis and processing of an Escherichia coli alkaline phosphatase precursor in vitro.

1977 • 171 citations

Studies on the Conversion of Proinsulin to Insulin

1973 • 168 citations

Isolation of a Glucagon-containing Peptide: Primary Structure of a Possible Fragment of Proglucagon

1973 • 165 citations

Detection and partial sequence analysis of gastrin mRNA by using an oligodeoxynucleotide probe.

1979 • 163 citations

High molecular weight forms of adrenocorticotropic hormone are glycoproteins.

1976 • 154 citations

Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region.

1978 • 153 citations

The spontaneous reoxidation of reduced beef and rat proinsulins.

1968 • 152 citations

Identification and processing of proglucagon in pancreatic islets

1979 • 142 citations

DIVISION OF BIOCHEMISTRY: EVIDENCE FOR A PRECURSOR IN THE BIOSYNTHESIS OF INSULIN*

1967 • 134 citations

An Escherichia coli mutant with an amino acid alteration within the signal sequence of outer membrane prolipoprotein.

1978 • 131 citations

Identical precursors for serum transferrin and egg white conalbumin.

1978 • 128 citations

Detection and kinetic behavior of preproinsulin in pancreatic islets.

1978 • 116 citations

Serum Levels of Luteinizing Hormone and Progesterone During the Estrous Cycle, Pseudopregnancy and Pregnancy in the Dog¹²³

1974 • 116 citations

The structure of rat proalbumin.

1975 • 115 citations

The degradation of proparathormone and parathormone by parathyroid and liver cathepsin B.

1979 • 108 citations

GASTROINTESTINAL HORMONES

1976 • 106 citations

Calcium-dependent Golgi-vesicle fusion and cathepsin B in the conversion of proalbumin into albumin in rat liver

1978 • 100 citations

On the Role of the Proinsulin C-peptide

1978 • 95 citations

Amino acid sequence of honeybee prepromelittin synthesized in vitro.

1978 • 91 citations

Cell Biology: A Comprehensive Treatise

1980 • 89 citations

Identification of prosomatostatin in pancreatic islets.

1980 • 80 citations

Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes

1978 • 80 citations

The N-Terminal Amino-Acid Sequence of Bovine Proparathyroid Hormone

1974 • 79 citations

POST‐TRANSLATIONAL PROCESSING OF FULL‐LENGTH PRESECRETORY PROTEINS WITH CANINE PANCREATIC SIGNAL PEPTIDASE

1980 • 76 citations

Regulation of mitochondrial protein synthesis by cytoplasmic proteins.

1976 • 74 citations

Nascent peptide as sole attachment of polysomes to membranes in bacteria.

1978 • 70 citations

Calcium ion-dependent vesicle fusion in the conversion of proalbumin to albumin

1978 • 68 citations

Studies on the Conversion of Proinsulin to Insulin

1973 • 65 citations

STRUCTURE AND BIOSYNTHESIS OF PEPTIDES RELATED TO CORTICOTROPINS AND β‐MELANOTROPINS

1977 • 62 citations

Enzymic processing of proparathyroid hormone by cell-free extracts of parathyroid glands

1977 • 62 citations

Identification of Human Glandular Kallikrein in the Beta Cell of the Pancreas

1979 • 60 citations

Amino terminal sequences of the precursors of ovine caseins

1977 • 58 citations

Role of ATP in the Intracellular Translocation of Proinsulin and Insulin in the Rat Pancreatic B Cell

1972 • 53 citations

Biosynthesis of Rat serum albumin

1971 • 51 citations

Pathogenesis of Diabetes Mellitus.

1971 • 50 citations

Post-translational processing and transport of the polyprotein precursor to subunits IV to VII of yeast cytochrome c oxidase.

1979 • 50 citations

Virus-specified protease in poliovirus-infected HeLa cells.

1979 • 46 citations

Complete amino acid sequence of the precursor region of rat prolactin

1978 • 41 citations

Conversion of rat pre-proalbumin to proalbumin in vitro by ascites membranes. Demonstration by NH2-TERMINAL SEQUENCE ANALYSIS.

1978 • 37 citations

A Bovine Pancreatic Enzyme Catalyzing the Conversion of Proinsulin to Insulin

1971 • 35 citations

Conversion of pre-proparathyroid hormone to proparathyroid hormone by dog pancreatic microsomes

1978 • 34 citations

Studies on the Conversion of Proinsulin to Insulin in the Isolated Islets of Langerhans in the Rat

1973 • 31 citations

Processing of prepromelittin by subcellular fractions from rat liver

1978 • 30 citations

A β‐LPH PRECURSOR MODEL: RECENT DEVELOPMENTS CONCERNING MORPHINE‐LIKE SUBSTANCES

1977 • 28 citations

Heterogeneity of Circulating Human C-peptide

1978 • 26 citations

Carboxypeptidase B‐Like and Trypsin‐Like Activities in Isolated Rat Pancreatic Islets

1976 • 25 citations

PROTEASE ACTIVITIES PRESENT IN DOG PANCREATIC MEMBRANES THAT PROCESS HUMAN PRE‐PLACENTAL LACTOGEN

1980 • 24 citations

The Localization of an Intracellular Membrane-Bound Proteinase from Rat Liver

1978 • 21 citations

Effect of pH on Conversion of Proinsulin to Insulin by a Subcellular Fraction of Rat Islets

1972 • 17 citations

Comparison of the Early Time Courses of the Release of Insulin That Follow Injections of Tetragastrin, Tolbutamide, Xylitol, and Glucose into the Pancreatic Artery of Dogs

1978 • 14 citations

PROCESSING OF PRE‐PROALBUMIN AND PRE‐PLACENTAL LACTOGEN*

1980 • 12 citations

BIOSYNTHESIS OF POLYPEPTIDE HORMONES IN INTACT AND CELL-FREE SYSTEMS

1978 • 9 citations

SECRETION OF OUTER MEMBRANE PROTEINS OF ESCHERICHIA COLI ACROSS THE CYTOPLASMIC MEMBRANE*

1980 • 4 citations