A novel serine protease (IRCM-serine protease 1) from porcine neurointermediate and anterior pituitary lobes. Isolation, polypeptide chain structure, inhibitor sensitivity, and substrate specificity with fluorogenic peptide substrates.

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

A simplified method for cyanogen bromide activation of agarose for affinity chromatography

1974 • 1,951 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

Proteases and biological control

1976 • 1,380 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Handbook of Experimental Pharmacology

1968 • 789 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

1982 • 672 citations

Mechanism of C-terminal amide formation by pituitary enzymes

1982 • 658 citations

Evolution of Proteolytic Enzymes

1984 • 641 citations

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

Blood Coagulation

1980 • 562 citations

Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursor

1982 • 553 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

The Proteolytic Activation Systems of Complement

1981 • 479 citations

PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS*

1980 • 461 citations

Isolation and characterization of a cDNA coding for human factor IX.

1982 • 415 citations

Role of proteolytic enzymes in biological regulation (a review).

1976 • 410 citations

Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid.

1983 • 363 citations

THE INHIBITION OF PLASMIN, PLASMA KALLIKREIN, PLASMA PERMEABILITY FACTOR, AND THE C'1r SUBCOMPONENT OF THE FIRST COMPONENT OF COMPLEMENT BY SERUM C'1 ESTERASE INHIBITOR

1969 • 334 citations

Direct identification of prohormone conversion site in insulin-secreting cells

1985 • 297 citations

Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase.

1983 • 265 citations

Inhibition of activated Hageman factor and activated plasma thromboplastin antecedent by purified serum C1 inactivator.

1970 • 224 citations

Purification and Specificity of Porcine Enterokinase

1971 • 224 citations

Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway. Kinetic behavior of two-chain factor VII in the presence and absence of tissue factor

1977 • 216 citations

Partial Purification of a Serum Inhibitor of C'1-Esterase

1961 • 193 citations

ISOLATION, PURIFICATION, AND CHARACTERIZATION OF γ-LIPOTROPIC HORMONE FROM SHEEP PITUITARY GLANDS

1967 • 191 citations

Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor

1982 • 190 citations

Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor)

1977 • 189 citations

Endorphins in Mental Health Research

1980 • 184 citations

Characterization of a cDNA coding for human protein C.

1984 • 183 citations

The insulin factory: a tour of the plant surroundings and a visit to the assembly line

1985 • 172 citations

The internal pH and membrane potential of the insulin-secretory granule

1982 • 172 citations

Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX

1983 • 163 citations

Interaction of ¹²⁵I‐labelled complement subcomponents Cr and Cs with protease inhibitors in plasma

1979 • 147 citations

Proteases and posttranslational processing of prohormones: a review

1983 • 144 citations

Differential elution of Clq, Cl̄r and Cl̄s from human CT bound to immune aggregates. use in the rapid purification of Cl̄ sub-components

1979 • 141 citations

Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary.

1984 • 139 citations

The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement

1977 • 129 citations

p-Guanidinobenzoic acid esters of fluorescein as active-site titrants of serine proteases

1982 • 128 citations

Isolation and Characterization of the Proenzyme Form of the C1s Subunit of the First Complement Component

1974 • 118 citations

THE ENZYMATIC NATURE OF C'1r

1968 • 116 citations

The structure of rat proalbumin.

1975 • 115 citations

Acetylation of alpha-melanotropin and beta-endorphin in the rat intermediate pituitary. Subcellular localization.

1982 • 111 citations

Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.

1981 • 105 citations

Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.

1983 • 102 citations

Secretion and Regulation of Two Biosynthetic Enzyme Activities, Peptidyl-Glycineα-Amidating Monooxygenase and a Carboxypeptidase, by Mouse Pituitary Corticotropic Tumor Cells*

1984 • 101 citations

COMPLEMENT AS A MEDIATOR OF INFLAMMATION

1963 • 97 citations

Characterization of the peptide acetyltransferase activity in bovine and rat intermediate pituitaries responsible for the acetylation of beta-endorphin and alpha-melanotropin.

1982 • 97 citations

Cloning and sequencing of liver cDNA coding for bovine protein C.

1984 • 95 citations

Structure, specificity and localization of the serine proteases of connective tissue

1980 • 95 citations

Activation of C1r by Proteolytic Cleavage

1976 • 95 citations

Biosynthesis of human preproapolipoprotein A-II.

1983 • 94 citations

Characterization of a cDNA coding for human factor X.

1984 • 94 citations

Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates

1981 • 93 citations

Measurement of delta pH and membrane potential in secretory vesicles isolated from bovine pituitary intermediate lobe.

1984 • 89 citations

Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage

1980 • 85 citations

Substrate specificity of an amidating enzyme in porcine pituitary

1983 • 82 citations

A Kininogenase Resembling Glandular Kallikrein in the Rat Pituitary Pars Intermedia

1983 • 76 citations

Blood coagulation factor X mRNA encodes a single polypeptide chain containing a prepro leader sequence

1984 • 72 citations

Subcellular fractionation studies on the post-translational processing of pro-adrenocorticotropic hormone/endorphin in rat intermediate pituitary.

1981 • 69 citations

The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.

1984 • 67 citations

A novel kinin-generating protease (kininogenase) in the porcine anterior pituitary.

1982 • 66 citations

Assembly of subcomponents C1r and C1s of first component of complement: electron microscopic and ultracentrifugal studies.

1980 • 66 citations

STUDIES ON HUMAN C'1-ESTERASE. II. FUNCTION OF PURIFIED C'1-ESTERASE IN THE HUMAN COMPLEMENT SYSTEM.

1964 • 62 citations

[5] Preparation and properties of human inhibitor

1981 • 58 citations

[4] The human complement system serine proteases and and their proenzymes

1981 • 54 citations

[47] Sperm acrosin

1981 • 52 citations

Mechanism of antibody-independent activation of the first component of complement (C1) on retrovirus membranes

1980 • 52 citations

Evidence for hemiacetal formation between N-acyl-L-phenylalaninals and .alpha.-chymotrypsin by cross-saturation nuclear magnetic resonance spectroscopy

1979 • 50 citations

Reaction of peptide aldehydes with serine proteases. Implications for the entropy changes associated with enzymic catalysis

1979 • 49 citations

Selective cleavage of human ACTH, beta-lipotropin, and the N-terminal glycopeptide at pairs of basic residues by IRCM-serine protease 1. Subcellular localization in small and large vesicles.

1986 • 48 citations

Isolation and characterization of bovine factor XI (plasma thromboplastin antecedent)

1977 • 46 citations

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

1979 • 44 citations

Human Factor D̄ of the Alternative Complement Pathway: Purification and Characterization

1977 • 43 citations

Isolation and Characterization of the Proenzyme form of the C1r Subunit of the First Complement Component

1974 • 42 citations

Active site mapping of human and rat urinary kallikreins by peptidyl chloromethyl ketones

1980 • 42 citations

Purification of proenzymic and activated human C1s free of Clr

1977 • 42 citations

Purification and characterization of subcomponent C1q of the first component of bovine complement

1979 • 38 citations

Mechanism of association of a specific aldehyde "transition-state analog" to the active site of .alpha.-chymotrypsin

1979 • 36 citations

Cathepsins B and H from porcine spleen. Purification, polypeptide chain arrangements, and carbohydrate content.

1984 • 34 citations

Studies on Human C′1-Esterase

1964 • 34 citations

Reactivity of bovine blood coagulation factor IXa.beta., factor Xa.beta., and factor XIa toward fluorogenic peptides containing the activation site sequences of bovine factor IX and factor X

1983 • 34 citations

Isolation and Comparison of the Proenzyme and Activated Forms of the Human Serum Complement Subcomponents C1r and C1s

1976 • 32 citations

A gross structure of an activated form of a subunit of the first component of human complement. Cl

1975 • 30 citations

Evidence for intragranular processing of pro-opiocortin in the mouse pituitary intermediate lobe.

1981 • 28 citations

Hormonal Proteins and Peptides

1981 • 28 citations

Purification, Characterization and Active-Site Studies on Human Serum Complement Subcomponent C1s

1973 • 24 citations

Release of Vasoactive Substances by Kinins

1979 • 23 citations

Structural basis for the specific activation of human enteropeptidase.

1978 • 22 citations

Isolation and characterization of different forms of C1, a subcomponent of the first component of human complement

1978 • 18 citations

Regional distribution of β-lipotropin converting enzymes in rat pituitary and brain

1977 • 18 citations

Isolation and characterization of four proteases from porcine pituitary neurointermediate lobes: Relationship to the maturation enzyme of prohormones

1985 • 16 citations

The Croonian Lecture, 1980 - The complex proteases of the complement system

1980 • 15 citations

[46] γ-Subunit of mouse submaxillary gland 7 S nerve growth factor: An endopeptidase of the serine family

1981 • 11 citations

The purification and characterization of subcomponent C1s of the first component of bovine complement

1979 • 11 citations

Activation of a latent kinin-generating proteinase in the porcine anterior pituitary

1984 • 10 citations

Proteolytic Cleavage of an Activated Subcomponent of the First Component of Rabbit Complement, C1¯s

1980 • 8 citations

Purification and Some Properties of Rabbit ClĪr

1979 • 5 citations

Centrally active peptides

1977 • 4 citations