Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

Ultrastructural localization of intracellular antigens by the use of protein A-gold complex.

1978 • 992 citations

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.

1986 • 331 citations

Macro- and Micro-Domains in the Endocrine Pancreas

1982 • 306 citations

Direct identification of prohormone conversion site in insulin-secreting cells

1985 • 297 citations

Visualization of acidic organelles in intact cells by electron microscopy.

1984 • 250 citations

Specimen preparation for electron microscopy using low temperature embedding resins

1982 • 240 citations

Proteolytic processing in the biosynthesis of insulin and other proteins.

1974 • 172 citations

Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.

1982 • 132 citations

A portrait of the pancreatic B-Cell

1974 • 129 citations

Human Proinsulin-Specific Antigenic Determinants Identified by Monoclonal Antibodies

1984 • 40 citations

Recognition of Human Insulin and Proinsulin by Monoclonal Antibodies

1985 • 32 citations