Members of the low density lipoprotein receptor family control diverse physiological processes

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

1999 • 1,231 citations

An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3

1999 • 989 citations

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

1999 • 902 citations

Reelin Is a Ligand for Lipoprotein Receptors

1999 • 803 citations

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

1989 • 680 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Receptor-mediated Endocytosis in theCaenorhabditis elegansOocyte

1999 • 586 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

Molecular characteristics of insect vitellogenins and vitellogenin receptors

1998 • 489 citations

Defective forebrain development in mice lacking gp330/megalin.

1996 • 485 citations

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

1992 • 466 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Members of the low density lipoprotein receptor familymediate cell entry of a minor-group common cold virus.

1994 • 456 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria

1999 • 432 citations

Human Apolipoprotein E Receptor 2

1996 • 378 citations

THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY

1999 • 362 citations

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.

1995 • 338 citations

Vitamin A-deficient quail embryos have half a hindbrain and other neural defects

1996 • 335 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.

1992 • 318 citations

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

2000 • 312 citations

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

1989 • 307 citations

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.

1988 • 281 citations

LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism

1995 • 272 citations

The intrinsic factor–vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

1999 • 268 citations

Megalin/gp330 mediates uptake of albumin in renal proximal tubule

1996 • 263 citations

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

1995 • 259 citations

Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP)

2000 • 256 citations

Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol

1999 • 238 citations

Molecular Characterization of a Novel Human Hybrid-type Receptor That Binds the α2-Macroglobulin Receptor-associated Protein

1996 • 236 citations

Role of the Low Density Lipoprotein-related Protein Receptor in Mediation of Factor VIII Catabolism

1999 • 227 citations

Identification of Glycoprotein 330 as an Endocytic Receptor for Apolipoprotein J/Clusterin

1995 • 220 citations

Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.

1996 • 211 citations

Embryonic development and pattern formation

1996 • 203 citations

Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member

1996 • 201 citations

Interaction of Apolipoprotein J-Amyloid β-Peptide Complex with Low Density Lipoprotein Receptor-related Protein-2/Megalin

1997 • 197 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands.

1998 • 183 citations

The Drosophila yolkless gene encodes a vitellogenin receptor belonging to the low density lipoprotein receptor superfamily.

1995 • 181 citations

Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

1995 • 181 citations

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

1994 • 177 citations

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes

1993 • 169 citations

Vitellogenin Receptors: Oocyte-Specific Members of the Low-Density Lipoprotein Receptor Supergene Family

1996 • 169 citations

The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor.

1997 • 164 citations

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

2000 • 162 citations

Megalin is an endocytic receptor for insulin.

1998 • 160 citations

Cellular Internalization and Degradation of Antithrombin III-Thrombin, Heparin Cofactor II-Thrombin, and α1-Antitrypsin-Trypsin Complexes Is Mediated by the Low Density Lipoprotein Receptor-related Protein

1996 • 159 citations

LDL Receptor-Related Protein as a Component of the Midkine Receptor

2000 • 158 citations

A gp330/megalin-related protein is required in the major epidermis ofCaenorhabditis elegansfor completion of molting

1999 • 157 citations

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase.

1992 • 157 citations

Cubilin, the endocytic receptor for intrinsic factor-vitamin B ₁₂ complex, mediates high-density lipoprotein holoparticle endocytosis

1999 • 154 citations

The Very Low Density Lipoprotein Receptor Mediates the Cellular Catabolism of Lipoprotein Lipase and Urokinase-Plasminogen Activator Inhibitor Type I Complexes

1995 • 153 citations

Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.

1992 • 147 citations

Megalin Acts in Concert with Cubilin to Mediate Endocytosis of High Density Lipoproteins

2000 • 144 citations

gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex.

1992 • 141 citations

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

1995 • 140 citations

A single chicken oocyte plasma membrane protein mediates uptake of very low density lipoprotein and vitellogenin.

1990 • 127 citations

Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro

1993 • 124 citations

Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

1998 • 124 citations

The Cellular Internalization and Degradation of Hepatic Lipase Is Mediated by Low Density Lipoprotein Receptor-related Protein and Requires Cell Surface Proteoglycans

1995 • 123 citations

Collagenase-3 Binds to a Specific Receptor and Requires the Low Density Lipoprotein Receptor-related Protein for Internalization

1999 • 122 citations

Specific Association of Megalin and the Na+/H+ Exchanger Isoform NHE3 in the Proximal Tubule

1999 • 122 citations

The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors

1995 • 121 citations

Megalin Antagonizes Activation of the Parathyroid Hormone Receptor

1999 • 121 citations

Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis.

1996 • 119 citations

Cellular Internalization and Degradation of Thrombospondin-1 Is Mediated by the Amino-terminal Heparin Binding Domain (HBD)

1997 • 117 citations

Purification of the Rat Hepatic α2-Macroglobulin Receptor as an Approximately 440-kDa Single Chain Protein

1989 • 112 citations

Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor Complex

1995 • 112 citations

The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor.

1994 • 110 citations

Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100

1995 • 103 citations

Avian riboflavin binding protein binds to lipoprotein receptors in association with vitellogenin.

1994 • 100 citations

A Protein Involved in Calcium Sensing of the Human Parathyroid and Placental Cytotrophoblast Cells Belongs to the LDL-Receptor Protein Superfamily

1994 • 97 citations

beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin.

1998 • 94 citations

Lipoprotein Lipase Binds to Low Density Lipoprotein Receptors and Induces Receptor-mediated Catabolism of Very Low Density Lipoproteins

1996 • 92 citations

Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP)

1998 • 90 citations

Specificity of Serine Proteinase/Serpin Complex Binding to Very-Low-Density Lipoprotein Receptor and alpha2-Macroglobulin Receptor/Low-Density-Lipoprotein-Receptor-Related Protein

1997 • 90 citations

Vitellogenesis in Xenopus laevis and chicken: cognate ligands and oocyte receptors. The binding site for vitellogenin is located on lipovitellin I.

1990 • 88 citations

Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor.

1994 • 85 citations

Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans.

1996 • 84 citations

Trichosanthin Interacts with and Enters Cells via LDL Receptor Family Members

2000 • 83 citations

Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg)

1998 • 74 citations

Plasminogen Activator Inhibitor-1 and Vitronectin Promote the Cellular Clearance of Thrombin by Low Density Lipoprotein Receptor-related Proteins 1 and 2

1996 • 72 citations

gp330 on type ii pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex

1995 • 71 citations

Identification of Megalin/gp330 as a Receptor for Lipoprotein(a) In Vitro

1999 • 71 citations

Female sterile (1) yolkless: a recessive female sterile mutation in Drosophila melanogaster with depressed numbers of coated pits and coated vesicles within the developing oocytes.

1987 • 69 citations

Metabolism of Thrombospondin 2

1996 • 68 citations

Multiple Involvement of Clusterin in Chicken Ovarian Follicle Development

1999 • 67 citations

Differential Recognition of α1-Antitrypsin-Elastase and α1-Antichymotrypsin-Cathepsin G Complexes by the Low Density Lipoprotein Receptor-related Protein

1995 • 65 citations

α₂‐Macroglobulin Receptor Mediates Binding and Cytotoxicity of Plant Ribosome‐Inactivating Proteins

1995 • 65 citations

The Efficient Catabolism of Thrombin-Protease Nexin 1 Complexes Is a Synergistic Mechanism That Requires Both the LDL Receptor-related Protein and Cell Surface Heparins

1997 • 58 citations

Expression and Characterization of a Very Low Density Lipoprotein Receptor Variant Lacking the O-Linked Sugar Region Generated by Alternative Splicing

1998 • 57 citations

Low Density Lipoprotein Receptor-Related Protein-2 Expression in Efferent Duct and Epididymal Epithelia: Evidence in Rats for its in Vivo Role in Endocytosis of Apolipoprotein J/Clusterin1

1996 • 57 citations

Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator.

1994 • 51 citations

Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M_r, 40,000 receptor associated protein

1994 • 49 citations

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

2000 • 40 citations

Very low density lipoprotein receptor binds apolipoprotein E2/2 as well as apolipoprotein E3/3

1996 • 39 citations

Receptor-mediated Endocytosis of Coagulation Factor Xa Requires Cell Surface-bound Tissue Factor Pathway Inhibitor

1996 • 34 citations

Metabolism of Activated Complement Component C3 Is Mediated by the Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor

1999 • 33 citations

Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg)

1998 • 26 citations

The LDL Receptor Gene Family, Apolipoprotein B and Cholesterol in Embryonic Development

1999 • 24 citations

Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E

2000 • 21 citations

Journal of Bone and Mineral Research

1991 • 19 citations

Identification of Low Density Lipoprotein Receptor-related Protein-2/megalin as an Endocytic Receptor for Seminal Vesicle Secretory Protein II

1999 • 16 citations

Prostate-specific antigen triggers transformation of seminal α2-macroglobulin (α2-M) and its binding to α2-macroglobulin receptor/low-density lipoprotein receptor-related protein (α2-M-R/LRP) on human spermatozoa

1998 • 15 citations

Immunohistochemical Localization of Alpha-2 Macroglobulin Receptor/Low-Density Lipoprotein Receptor-Related Protein, Receptor-Associated Protein, and Gp330 in the Human Endometrium

1995 • 15 citations

Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E

2000 • 13 citations

Pathophysiology of primary hyperparathyroidism.

2000 • 12 citations

Low density lipoprotein receptor-related protein-1 expression in the testis: regulated expression in Sertoli cells.

1997 • 9 citations

Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin.

1995 • 9 citations

Low Density Lipoprotein Receptor‐Related Protein‐1 Expression in the Testis: Regulated Expression in Sertoli Cells

1997 • 8 citations