Evidence for two distinct 60-kilodalton substrates of the SRC tyrosine kinase.

Oncogenes and signal transduction

1991 • 2,816 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1994 • 407 citations

A target for Src in mitosis

1994 • 361 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.

1992 • 281 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.

1994 • 235 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle.

1993 • 220 citations

The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

1993 • 120 citations

The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.

1992 • 99 citations

The p60c-src family of protein-tyrosine kinases: structure, regulation, and function.

1992 • 97 citations

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.

1994 • 94 citations

Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.

1991 • 88 citations

Closing in on SH2 specificity

1993 • 86 citations

Characterization of a 60-kilodalton substrate of the insulin receptor kinase

1994 • 80 citations

Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.

1994 • 78 citations

Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62

1992 • 78 citations

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation.

1992 • 73 citations

Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85.

1992 • 63 citations

Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene.

1990 • 52 citations

Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.

1993 • 45 citations

Identification and Characterization of Novel Substrates for Protein Tyrosine Kinases

1993 • 36 citations

Functional Role of GTPase-Activating Protein in Cell Transformation by pp6O^v-src

1993 • 29 citations

Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.

1992 • 29 citations

Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex

1992 • 28 citations