Blockade of CD28 During In Vitro Activation of Encephalitogenic T Cells or After Disease Onset Ameliorates Experimental Autoimmune Encephalomyelitis

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Epitope spreading

1996 • 302 citations

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.

1996 • 232 citations

Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response.

1995 • 220 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1995 • 194 citations

Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.

1995 • 160 citations

Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.

1995 • 153 citations

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.

1998 • 137 citations

Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo

1996 • 132 citations

Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

1995 • 125 citations

Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system

1997 • 124 citations

CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion

1997 • 120 citations

Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction

1998 • 111 citations

Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis

1997 • 102 citations

Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

1982 • 95 citations

Protection against lethal toxic shock by targeted disruption of the CD28 gene.

1996 • 72 citations

Inhibition by CTLA4Ig of experimental allergic encephalomyelitis.

1996 • 60 citations

Induction of autoimmunity in the absence of CD28 costimulation.

1996 • 49 citations

Mitogenic stimulation of T cells reveals differing contributions for B7‐1 (CD80) and B7‐2 (CD86) costimulation

1997 • 47 citations

Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE

1997 • 47 citations

Opposing effects of CTLA4-Ig and Anti-CD80 (B7-1) plus Anti-CD86 (B7-2) on experimental allergic encephalomyelitis

1996 • 47 citations

CD28 ligation prevents bacterial toxin-induced septic shock in mice by inducing IL-10 expression.

1997 • 25 citations

Experimental Autoimmune Meningitis: A Novel Neurological Disease in CD28-Deficient Mice

1999 • 25 citations

Inhibitors of tumor necrosis factor-α: Promising agents for the treatment of multiple sclerosis?

1996 • 20 citations

Global Inhibition of IL-2 and IFN-γ Secreting T cells Precedes Recovery from Acute Monophasic Experimental Autoimmune Encephalomyelitis

1996 • 15 citations

Myelin basic crotein-specific and TCR V?8.2-Specific T-cell lines from TCR V?8.2 transgenic mice utilize the same V? and V? genes: specificity associated with the V? CDR3-J? region

1997 • 14 citations