Mitochondrial biogenesis and healthy aging

Resveratrol improves health and survival of mice on a high-calorie diet

2006 • 4,102 citations

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

2006 • 3,767 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

2007 • 2,203 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

2000 • 1,269 citations

Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide

2003 • 1,199 citations

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

2005 • 1,075 citations

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

2006 • 958 citations

Resveratrol stimulates AMP kinase activity in neurons

2007 • 709 citations

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

2006 • 664 citations

Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK

2002 • 659 citations

The mitochondrial energy transduction system and the aging process

2006 • 642 citations

Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators

2005 • 631 citations

Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

2003 • 630 citations

Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress

2004 • 624 citations

Nuclear activators and coactivators in mammalian mitochondrial biogenesis

2002 • 611 citations

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

2006 • 605 citations

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

2004 • 600 citations

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

1999 • 584 citations

Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

2007 • 512 citations

Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5

2003 • 409 citations

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α

2006 • 408 citations

MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2

2006 • 386 citations

Effects of Exercise on Mitochondrial Content and Function in Aging Human Skeletal Muscle

2006 • 379 citations

Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

2003 • 377 citations

PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations

2003 • 320 citations

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK

2004 • 287 citations

Mitochondrial Fission and Fusion Mediators, hFis1 and OPA1, Modulate Cellular Senescence

2007 • 277 citations

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells

2006 • 277 citations

Nitric oxide and mitochondrial biogenesis

2006 • 271 citations

Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence

2002 • 268 citations

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes

2005 • 230 citations

A Regulatory Role for RIP140 in Nuclear Receptor Activation

1998 • 222 citations

Regulation of Mitochondrial Biogenesis by Thyroid Hormone

2003 • 205 citations

Aging networks in Caenorhabditis elegans: AMP‐activated protein kinase (aak‐2) links multiple aging and metabolism pathways

2006 • 196 citations

Regulation and Co‐Ordination of Nuclear Gene Expression During Mitochondrial Biogenesis

2003 • 172 citations

Nitric oxide and mitochondria

2006 • 161 citations

Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons

2005 • 155 citations

Nuclear receptors, mitochondria and lipid metabolism

2008 • 141 citations

Structural Organization and Transcription Regulation of Nuclear Genes Encoding the Mammalian Cytochrome c Oxidase Complex

1998 • 137 citations

Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis

2007 • 137 citations

Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity

2004 • 116 citations

Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKα

2007 • 107 citations

Role of AMP-Activated Protein Kinase in the Molecular Adaptation to Endurance Exercise

2006 • 104 citations

Expression of mitochondrial biogenesis-signaling factors in brown adipocytes is influenced specifically by 17β-estradiol, testosterone, and progesterone

2006 • 103 citations

Localization of the transcriptional coactivator PGC‐1α to GABAergic neurons during maturation of the rat brain

2007 • 102 citations

Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts

2005 • 101 citations

The biogenesis of mitochondria

1969 • 99 citations

Peroxisomal Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Enhances the Thyroid Hormone Induction of Carnitine Palmitoyltransferase I (CPT-Iα)

2004 • 95 citations

Caloric Restriction Protects Mitochondrial Function with Aging in Skeletal and Cardiac Muscles

2006 • 93 citations

Blood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old

2000 • 89 citations

Modulation of Sirtuins: New Targets for Antiageing

2008 • 88 citations

No Decline in Skeletal Muscle Oxidative Capacity With Aging in Long-Term Calorically Restricted Rats: Effects Are Independent of Mitochondrial DNA Integrity

2006 • 86 citations

PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage

2005 • 79 citations

Chronic activation of AMP-activated kinase as a strategy for slowing aging

2004 • 78 citations

BIOGENESIS OF MITOCHONDRIA

1970 • 77 citations

Sequential changes in the signal transduction responses of skeletal muscle following food deprivation

2006 • 76 citations

The biogenesis of mitochondria, VI. Biochemical basis of the resistance of Saccharomyces cerevisiae toward antibiotics which specifically inhibit mitochondrial protein synthesis.

1968 • 76 citations

Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle

2006 • 73 citations

Differential effects of thyroid hormones on energy metabolism of rat slow‐ and fast‐twitch muscles

2004 • 68 citations

Role of RIP140 in metabolic tissues: Connections to disease

2007 • 67 citations

Mitochondrial Biogenesis in Skeletal Muscle in Response to Endurance Exercises

1996 • 67 citations

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α

2006 • 66 citations

A Regulatory Role for RIP140 in Nuclear Receptor Activation

1998 • 58 citations

Mitochondrial biogenesis and mitochondrial activity during the progression of the cell cycle of human leukemic cells

1988 • 57 citations

Bioenergetic remodeling of heart mitochondria by thyroid hormone

2004 • 54 citations

Stimulated rat liver mitochondrial biogenesis after partial hepatectomy.

1989 • 54 citations

Mitochondrial biogenesis in striated muscles: rapid induction of citrate synthase mRNA by nerve stimulation

1991 • 44 citations

Thyroid hormone and not growth hormone is the principle regulator of mammalian mitochondrial biogenesis

1989 • 44 citations

Biogenesis of mitochondria 36

1975 • 40 citations

Changes in number of synapses and mitochondria in presynaptic terminals in the dentate gyrus following cerebral ischemia and rehabilitation training

2005 • 36 citations

Caloric restriction and mitochondrial function in the ageing myocardium

2006 • 35 citations

PGC-1α is induced by parathyroid hormone and coactivates Nurr1-mediated promoter activity in osteoblasts

2006 • 33 citations

A Growth Hormone-Releasing Peptide Promotes Mitochondrial Biogenesis and a Fat Burning-Like Phenotype through Scavenger Receptor CD36 in White Adipocytes

2006 • 32 citations

Mitochondrial biogenesis: Which part of “NO” do we understand?

2003 • 32 citations

Developmental changes in mitochondria during the transition into lactation in the mouse mammary gland.

1976 • 31 citations

Development of the mitochondrial mass and accumulation of mtdna in previtellogenic stages of Xenopus laevis oocytes

1980 • 30 citations

Biogenesis of mitochondria

1970 • 29 citations

Biogenesis of mitochondria 40

1975 • 27 citations

Thyroid Disease in Older Patients

1995 • 26 citations

Blood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old

2000 • 26 citations

Effects of adrenal steroid hormones on mitochondrial maturation during the late fetal period

1998 • 24 citations

The effect of thyroid hormone on mitochondrial biogenesis and cellular hyperplasia

1980 • 22 citations

Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: potential molecular targets for cancer therapy

2006 • 15 citations

Biogenesis of Mitochondrial Membranes in Neurospora crassa during Cellular Differentiation: Changes in Oxidative Phosphorylation and Synthesis of Mitochondrial Phospholipids

1976 • 7 citations

Biogenesis of Mitochondrial Membranes in Neurospora crassa during Cellular Differentiation: Ultrastructural Changes Accompanying Differentiation

1976 • 6 citations