Role of AMP-Activated Protein Kinase in the Molecular Adaptation to Endurance Exercise

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator

2003 • 1,964 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

2003 • 1,604 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

2005 • 1,518 citations

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

2004 • 1,208 citations

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

2000 • 1,125 citations

Biochemical Adaptations to Endurance Exercise in Muscle

1976 • 1,031 citations

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

2002 • 1,010 citations

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

1999 • 1,009 citations

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1

2002 • 998 citations

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

2002 • 829 citations

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

1996 • 794 citations

Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

2000 • 720 citations

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

2004 • 699 citations

Exercise Stimulates Pgc-1α Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway

2005 • 658 citations

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

2001 • 642 citations

Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

2001 • 545 citations

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

2005 • 542 citations

Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity

2005 • 526 citations

Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

1999 • 506 citations

Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation

2005 • 472 citations

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle

2003 • 441 citations

Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

2000 • 431 citations

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

1997 • 404 citations

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle

2002 • 363 citations

PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations

2003 • 320 citations

Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle

2002 • 309 citations

PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle

2004 • 282 citations

Effects of α‐AMPK knockout on exercise‐induced gene activation in mouse skeletal muscle

2005 • 270 citations

Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle

2004 • 261 citations

cDNA Cloning and mRNA Analysis of PGC-1 in Epitrochlearis Muscle in Swimming-Exercised Rats

2000 • 259 citations

New roles for the LKB1→AMPK pathway

2005 • 256 citations

Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles

2003 • 253 citations

Role of Ca²⁺/calmodulin-dependent kinases in skeletal muscle plasticity

2005 • 199 citations

Chronic Treatment With 5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside Increases Insulin-Stimulated Glucose Uptake and GLUT4 Translocation in Rat Skeletal Muscles in a Fiber Type--Specific Manner

2001 • 190 citations

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase

2000 • 172 citations

Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles

2003 • 171 citations

Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase

1997 • 164 citations

Intrasteric control of AMPK via the γ₁ subunit AMP allosteric regulatory site

2003 • 159 citations

AMP-Activated Protein Kinase: A Key System Mediating Metabolic Responses to Exercise

2004 • 159 citations

Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles

2002 • 144 citations

Short‐term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen

2005 • 138 citations

Role of nitric oxide in the regulation of HIF-1α expression during hypoxia

2002 • 136 citations

Involvement of PPARγ co-activator-1, nuclear respiratory factors 1 and 2, and PPARα in the adaptive response to endurance exercise

2004 • 134 citations

Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase

2005 • 121 citations

AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions

2003 • 104 citations

LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training

2005 • 101 citations

AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions

2003 • 77 citations

AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle

2004 • 64 citations

UCP3 Protein Regulation in Human Skeletal Muscle Fibre Types I, IIa and IIx is Dependent on Exercise Intensity

2003 • 62 citations

AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats

2005 • 31 citations

Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle

2004 • 30 citations

Effect of muscimol and <scp>l</scp>-NAME in the PVN on the RSNA response to volume expansion in conscious rabbits

2004 • 29 citations