Caloric restriction and mitochondrial function in the ageing myocardium

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

2004 • 3,483 citations

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

2005 • 3,020 citations

Premature ageing in mice expressing defective mitochondrial DNA polymerase

2004 • 2,561 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

2004 • 2,151 citations

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 • 2,025 citations

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

2003 • 1,893 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide

2003 • 1,199 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

2005 • 1,075 citations

Overview of caloric restriction and ageing

2005 • 1,040 citations

Receptor-mediated regional sympathetic nerve activation by leptin.

1997 • 980 citations

ErbB2 is essential in the prevention of dilated cardiomyopathy

2002 • 875 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity

2003 • 654 citations

Caloric restriction and aging: an update

2000 • 616 citations

Toward a unified theory of caloric restriction and longevity regulation

2005 • 568 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals

2004 • 485 citations

Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis

1997 • 471 citations

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

2002 • 461 citations

DNA Polymerase γ, The Mitochondrial Replicase

2003 • 398 citations

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

2001 • 369 citations

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

1998 • 352 citations

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1994 • 346 citations

Inactivation of Glutathione Peroxidase by Nitric Oxide

1995 • 304 citations

Molecular mechanisms linking calorie restriction and longevity

2002 • 303 citations

Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

1996 • 275 citations

Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes

2004 • 229 citations

Endogenous oxidative stress: relationship to aging, longevity and caloric restriction

2002 • 215 citations

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

2002 • 205 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

1999 • 199 citations

Mitochondrial mutational spectra in human cells and tissues

1997 • 181 citations

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

1999 • 176 citations

Preconditioning does not prevent postischemic dysfunction in aging heart

1996 • 171 citations

Hormesis and the Antiaging Action of Dietary Restriction

1998 • 166 citations

Loss of Preconditioning by Attenuated Activation of Myocardial ATP-Sensitive Potassium Channels in Elderly Patients Undergoing Coronary Angioplasty

2002 • 158 citations

Caloric Restriction Attenuates Dityrosine Cross-Linking of Cardiac and Skeletal Muscle Proteins in Aging Mice

1997 • 148 citations

Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression

2002 • 132 citations

Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis

1999 • 130 citations

Mechanisms of Nitric Oxide-Dependent Apoptosis: Involvement of Mitochondrial Mediators

1999 • 128 citations

The Future of Aging Interventions: Aging Intervention, Prevention, and Therapy Through Hormesis

2004 • 119 citations

Lessons learned from gene expression profile studies of aging and caloric restriction

2004 • 104 citations

Neuregulin receptors erbB2 and erbB4 in failing human myocardium

2005 • 103 citations

Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts

2005 • 101 citations

Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats

2002 • 86 citations

Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal

2005 • 80 citations

The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats

2000 • 73 citations

Food Restriction Suppresses an Age-Dependent Increase in the Exhalation Rate of Pentane From Rats: A Longitudinal Study

1993 • 71 citations

Apoptosis-modulating interaction of the neuregulin/erbB pathway with antracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes

2005 • 69 citations

Decrease in Ischemic Tolerance with Aging in Isolated Perfused Fischer 344 Rat Hearts: Relation to Increases in Intracellular Na+After Ischemia

1997 • 64 citations

Frequent Intracellular Clonal Expansions of Somatic mtDNA Mutations

2002 • 59 citations

Concurrent reductions in blood pressure and metabolic rate during fasting in the unrestrained SHR

2000 • 58 citations

β-Adrenergic receptor blockade modulates Bcl-XS expression and reduces apoptosis in failing myocardium

2003 • 46 citations

For debate: defective mitochondria, free radicals, cell death, aging-reality or myth-ochondria?

2000 • 42 citations

Deleted Work

1955 • 0 citations