No Decline in Skeletal Muscle Oxidative Capacity With Aging in Long-Term Calorically Restricted Rats: Effects Are Independent of Mitochondrial DNA Integrity

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

Primer of biostatistics

1981 • 2,697 citations

Premature ageing in mice expressing defective mitochondrial DNA polymerase

2004 • 2,561 citations

[1] Citrate synthase

1969 • 1,958 citations

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1

2002 • 998 citations

Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle

2003 • 868 citations

Mitochondrial threshold effects

2003 • 750 citations

Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program

1999 • 658 citations

Oxidative capacity and ageing in human muscle

2000 • 620 citations

Effect of age onin vivorates of mitochondrial protein synthesis in human skeletal muscle

1996 • 552 citations

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

1991 • 548 citations

Histochemical and Enzymatic Comparison of the Gastrocnemius Muscle of Young and Elderly Men and Women

1992 • 453 citations

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle

2003 • 441 citations

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

2001 • 369 citations

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

2001 • 368 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart

2003 • 277 citations

Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria

2002 • 276 citations

Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria

1998 • 253 citations

Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis

2004 • 251 citations

Histochemical and metabolic characteristics of human skeletal muscle in relation to age

1986 • 241 citations

Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia

2002 • 230 citations

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress

2002 • 229 citations

The Effect of Retardation of Growth Upon the Breeding Period and Duration of Life of Rats

1917 • 178 citations

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection

2001 • 171 citations

Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle

2002 • 170 citations

Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production

2004 • 166 citations

Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans

2003 • 162 citations

Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle

1997 • 162 citations

Primer of Biostatistics, 5th ed

2002 • 159 citations

Subfield History: Caloric Restriction, Slowing Aging, and Extending Life

2003 • 146 citations

Complexity of Age-Related Change in Skeletal Muscle

1996 • 139 citations

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1995 • 123 citations

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

1998 • 120 citations

Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction

2004 • 115 citations

Multiple Mitochondrial DNA Deletions Associated With Age in Skeletal Muscle of Rhesus Monkeys

1993 • 114 citations

Influences of Age and Dietary Restriction on Gastrocnemius Electron Transport System Activities in Mice

1996 • 110 citations

Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria

2004 • 109 citations

Skeletal Muscle Aging in F344BN F1-Hybrid Rats: I. Mitochondrial Dysfunction Contributes to the Age-Associated Reduction in VO2max

2004 • 102 citations

Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages.

1993 • 99 citations

Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila

1998 • 94 citations

Effects of physical training on skeletal muscle metabolism and ultrastructure in 70 to 75‐year‐old men

1980 • 89 citations

No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA

2004 • 86 citations

Mitochondrial DNA Deletion Mutations and Sarcopenia

2002 • 85 citations

Implications of Protein Degradation in Aging

2001 • 83 citations

Effects of Caloric Restriction on Skeletal Muscle Mitochondrial Proton Leak in Aging Rats

2001 • 83 citations

Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity

2003 • 80 citations

Long‐term caloric restriction abrogates the age‐related decline in skeletal muscle aerobic function

2005 • 78 citations

Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys

2000 • 74 citations

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

1994 • 69 citations

Calorie Restriction Enhances the Expression of Key Metabolic Enzymes Associated with Protein Renewal during Aging

2001 • 62 citations

Greater capillary-fiber interface per fiber mitochondrial volume in skeletal muscles of old rats

2005 • 61 citations

[44]Detection and analysis of mitochondrial DNA and RNA in muscle by in situ hybridization and single-fiber PCR

1996 • 56 citations

Influences of Caloric Restriction on Age‐associated Skeletal Muscle Fiber Characteristics and Mitochondrial Changes in Rats and Mice^a

1998 • 55 citations

Mitochondrial ageing

2003 • 45 citations

Effectiveness of Caloric Restriction in Preventing Age-Related Changes in Rat Skeletal Muscle

1998 • 43 citations

Age-associated mitochondrial DNA deletions in mouse skeletal muscle: Comparison of different regions of the mitochondrial genome

1996 • 38 citations

Bioenergetics in the aging fischer 344 rat: Effects of exercise and food restriction

1987 • 32 citations

The Effect of the β₂-Adrenoceptor Agonist Prodrug BRL-47672 on Cardiovascular Function, Skeletal Muscle Myosin Heavy Chain, and MyoD Expression in the Rat

2004 • 17 citations

Stochastic mitochondrial DNA changes: bioenergy decline in type I skeletal muscle fibres correlates with a decline in the amount of amplifiable full-length mtDNA.

2002 • 16 citations

Low Levels of mtDNA Deletion Mutations in ETS Normal Fibers from Aged Rats

2004 • 9 citations