The helix bundle: A reversible lipid binding motif

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

1992 • 852 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

1991 • 661 citations

Apolipoprotein E structure: insights into function

2006 • 524 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2008 • 496 citations

Lipoprotein Receptors in the Nervous System

2002 • 441 citations

Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation

1997 • 417 citations

Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism

2000 • 413 citations

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

1985 • 352 citations

The Amphipathic α Helix: A Multifunctional Structural Motif in Plasma Apolipoproteins

1994 • 307 citations

Differences in Stability among the Human Apolipoprotein E Isoforms Determined by the Amino-Terminal Domain

2000 • 301 citations

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

1988 • 285 citations

TIP47 functions in the biogenesis of lipid droplets

2009 • 249 citations

Molecular structure of an apolipoprotein determined at 2.5-.ANG. resolution

1991 • 234 citations

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

1988 • 229 citations

Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins

2004 • 213 citations

Meat‐Adaptive Genes and the Evolution of Slower Aging in Humans

2004 • 209 citations

Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

1999 • 207 citations

RETRACTED: Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases

2006 • 205 citations

Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes

2008 • 197 citations

The Structure of Apolipoprotein A-I in High Density Lipoproteins

2007 • 196 citations

Apolipoprotein E4 Forms a Molten Globule

2002 • 195 citations

Lipophorin: The Structure of an Insect Lipoprotein and Its Role in Lipid Transport in Insects

1994 • 195 citations

Lipid Transport in Insects

1988 • 193 citations

Only the Two End Helixes of Eight Tandem Amphipathic Helical Domains of Human Apo A-I Have Significant Lipid Affinity

1996 • 192 citations

Structure of a Lipid Droplet Protein

2004 • 191 citations

Apolipophorin III: Role model apolipoprotein

2006 • 186 citations

Lipid Transport Biochemistry and Its Role in Energy Production

2000 • 179 citations

α-Helical Protein Assembly Motifs

1997 • 178 citations

Thermal unfolding of human high-density apolipoprotein A-1: implications for a lipid-free molten globular state.

1996 • 165 citations

Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization

1993 • 165 citations

Molecular basis of exchangeable apolipoprotein function

2000 • 153 citations

Adipokinetic hormones of insect: Release, signal transduction, and responses

2001 • 145 citations

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

2008 • 145 citations

The Structure of Human Lipoprotein A-I

1999 • 130 citations

Lipid transport function of lipoproteins in flying insects

1990 • 125 citations

Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia

1996 • 123 citations

Inter-molecular Coiled-coil Formation in Human Apolipoprotein E C-terminal Domain

2003 • 119 citations

Apolipoprotein A-I Assumes a “Looped Belt” Conformation on Reconstituted High Density Lipoprotein

2006 • 118 citations

Molecular regulation of macrophage reverse cholesterol transport

2007 • 113 citations

Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

1992 • 112 citations

Lipid Binding-induced Conformational Change in Human Apolipoprotein E

2001 • 111 citations

Dynamics of insect lipophorin metabolism

1990 • 111 citations

Kinetics of lipid-protein interactions: effect of cholesterol on the association of human plasma high-density apolipoprotein A-I with L-.alpha.-dimyristoylphosphatidylcholine

1979 • 109 citations

Apolipoprotein-mediated cellular cholesterol efflux

1998 • 108 citations

Truncation of the Amino Terminus of Human Apolipoprotein A-I Substantially Alters Only the Lipid-Free Conformation

1997 • 108 citations

The Spatial Organization of Apolipoprotein A-I on the Edge of Discoidal High Density Lipoprotein Particles

2003 • 107 citations

Alternative lipid mobilization: the insect shuttle system.

2002 • 104 citations

Binding of insect apolipophorin III to dimyristoylphosphatidylcholine vesicles. Evidence for a conformational change.

1994 • 104 citations

An insect homolog of the vertebrate very low density lipoprotein receptor mediates endocytosis of lipophorins

1999 • 102 citations

Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein

2002 • 102 citations

The role of apolipophorin III in in vivo lipoprotein interconversions in adult Manduca sexta.

1987 • 101 citations

Three-dimensional models of HDL apoA-I: implications for its assembly and function

2008 • 100 citations

New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E

2001 • 95 citations

Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid

2000 • 95 citations

Intermolecular Contact between Globular N-terminal Fold and C-terminal Domain of ApoA-I Stabilizes Its Lipid-bound Conformation

2005 • 95 citations

Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein

1994 • 93 citations

An Insect Lipid Transfer Particle Promotes Lipid Loading from Fat Body to Lipoprotein

1989 • 92 citations

Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization

2002 • 92 citations

Arrangement of Apolipoprotein A-I in Reconstituted High-Density Lipoprotein Disks: An Alternative Model Based on Fluorescence Resonance Energy Transfer Experiments

2001 • 91 citations

Structure of the Asn-linked oligosaccharides of apolipophorin III from the insect Locusta migratoria. Carbohydrate-linked 2-aminoethylphosphonate as a constituent of a glycoprotein

1993 • 90 citations

The Low Density Lipoprotein Receptor Active Conformation of Apolipoprotein E

1998 • 90 citations

Model of Biologically Active Apolipoprotein E Bound to Dipalmitoylphosphatidylcholine

2005 • 89 citations

Structure-function relationships of apolipoprotein A-I: a flexible protein with dynamic lipid associations

2003 • 88 citations

Modulation of Apolipoprotein E Structure by Domain Interaction

2005 • 87 citations

Human apolipoprotein A-I forms thermally stable complexes with anionic but not with zwitterionic phospholipids.

1986 • 87 citations

Atheroprotective Effects of HDL: Beyond Reverse Cholesterol Transport

2008 • 83 citations

Prevention of phospholipase‐C induced aggregation of low density lipoprotein by amphipathic apolipoproteins

1993 • 82 citations

Investigation of the lipid domains and apolipoprotein orientation in reconstituted high density lipoproteins by fluorescence and IR methods.

1990 • 81 citations

Helix Orientation of the Functional Domains in Apolipoprotein E in Discoidal High Density Lipoprotein Particles

2004 • 81 citations

Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins

2005 • 80 citations

Characterization of the Heparin Binding Sites in Human Apolipoprotein E

2003 • 80 citations

Structural Determination of Lipid-bound ApoA-I Using Fluorescence Resonance Energy Transfer

2000 • 79 citations

The Lipid-associated Conformation of the Low Density Lipoprotein Receptor Binding Domain of Human Apolipoprotein E

2000 • 77 citations

Apolipoprotein A-I Adopts a Belt-like Orientation in Reconstituted High Density Lipoproteins

2001 • 77 citations

The Lipid-Free Structure of Apolipoprotein A-I: Effects of Amino-Terminal Deletions

1998 • 76 citations

A Monomeric, Biologically Active, Full-Length Human Apolipoprotein E

2007 • 74 citations

Conformational, thermodynamic, and stability properties of Manduca sexta apolipophorin III.

1993 • 74 citations

Contributions of the N- and C-Terminal Helical Segments to the Lipid-Free Structure and Lipid Interaction of Apolipoprotein A-I

2006 • 73 citations

Circulatory lipid transport: lipoprotein assembly and function from an evolutionary perspective

2009 • 69 citations

Disulfide Bond Engineering to Monitor Conformational Opening of Apolipophorin III During Lipid Binding

1996 • 68 citations

Lipid-triggered Conformational Switch of Apolipophorin III Helix Bundle to an Extended Helix Organization

2002 • 68 citations

Identification and Structural Ramifications of a Hinge Domain in Apolipoprotein A-I Discoidal High-density Lipoproteins of Different Size

2004 • 65 citations

Deletion of the C-Terminal Domain of Apolipoprotein A-I Impairs Cell Surface Binding and Lipid Efflux in Macrophage

1999 • 63 citations

Electron Paramagnetic Resonance Spectroscopy of Site-directed Spin Labels Reveals the Structural Heterogeneity in the N-terminal Domain of ApoA-I in Solution

2007 • 63 citations

Hydrogen/Deuterium Exchange Kinetics of Apolipophorin-III in Lipid-free and Phospholipid-bound States

1996 • 62 citations

Structural Organization of the N-Terminal Domain of Apolipoprotein A-I: Studies of Tryptophan Mutants^†

1999 • 62 citations

Lipophorin nomenclature

1988 • 58 citations

Facilitated diacylglycerol exchange between insect hemolymph lipophorins. Properties of Manduca sexta lipid transfer particle.

1988 • 58 citations

Effect of guanidine hydrochloride on the hydrodynamic and thermodynamic properties of human apolipoprotein A-I in solution.

1980 • 58 citations

Apolipoprotein E•dipalmitoylphosphatidylcholine particles are ellipsoidal in solution

2007 • 56 citations

Lipid Association-induced N- and C-terminal Domain Reorganization in Human Apolipoprotein E3

2001 • 56 citations

Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender

1998 • 55 citations

Alignment of the Apolipophorin-III α-Helices in Complex with Dimyristoylphosphatidylcholine.

1995 • 53 citations

Factors Affecting the Stability and Conformation of Locusta migratoria Apolipophorin III

1994 • 52 citations

Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue

2002 • 52 citations

NMR Solution Structure and Dynamics of an Exchangeable Apolipoprotein, Locusta migratoria Apolipophorin III

2003 • 51 citations

Conformational Flexibility of the N-Terminal Domain of Apolipoprotein A-I Bound to Spherical Lipid Particles

2008 • 51 citations

Structure of Apolipophorin-III in Discoidal Lipoproteins

2002 • 49 citations

An insect lipoprotein hybrid helps to define the role of apolipophorin III.

1988 • 49 citations

A molecular trigger of lipid binding-induced opening of a helix bundle exchangeable apolipoprotein

1999 • 48 citations

A Unified Scheme for Initiation and Conformational Adaptation of Human Apolipoprotein E N-terminal Domain upon Lipoprotein Binding and for Receptor Binding Activity

2009 • 48 citations

Biosynthesis and secretion of insect lipoprotein: involvement of furin in cleavage of the apoB homolog, apolipophorin-II/I

2004 • 47 citations

Modulation of the lipid binding properties of the N‐terminal domain of human apolipoprotein E3

2001 • 47 citations

Interaction between the N- and C-Terminal Domains Modulates the Stability and Lipid Binding of Apolipoprotein A-I

2009 • 44 citations

Conformational flexibility in the apolipoprotein E amino‐terminal domain structure determined from three new crystal forms: Implications for lipid binding

2000 • 44 citations

Apolipophorin III: Lipopolysaccharide binding requires helix bundle opening

2006 • 43 citations

Immunocytochemical localization of lipophorins in the flight muscles of the migratory locust (Locusts migratoria) at rest and during flight

1988 • 41 citations

A Monomeric Human Apolipoprotein E Carboxyl-Terminal Domain

2004 • 41 citations

The Lipid Binding Activity of the Exchangeable Apolipoprotein Apolipophorin-III Correlates with the Formation of a Partially Folded Conformation

1998 • 40 citations

Amphipathic α-Helix Bundle Organization of Lipid-Free Chicken Apolipoprotein A-I

1999 • 40 citations

Interaction of an Exchangeable Apolipoprotein with Phospholipid Vesicles and Lipoprotein Particles

1999 • 39 citations

Engineering Conformational Destabilization into Mouse Apolipoprotein E

2005 • 39 citations

Combined N- and C-Terminal Truncation of Human Apolipoprotein A-I Yields a Folded, Functional Central Domain

2005 • 39 citations

Structural Studies of N- and C-Terminally Truncated Human Apolipoprotein A-I

2003 • 37 citations

Different isoforms of an apoprotein (apolipophorin III) associate with lipoproteins in Locusta migratoria

1991 • 37 citations

Examination of Lipid-bound Conformation of Apolipoprotein E4 by Pyrene Excimer Fluorescence

2005 • 37 citations

Native-like structure and self-association behavior of apolipoprotein A-I in a water/n-propanol solution

1994 • 35 citations

Förster Resonance Energy Transfer Measurements Are Consistent with a Helical Bundle Model for Lipid-Free Apolipoprotein A-I

2005 • 35 citations

Orientation and mode of lipid-binding interaction of human apolipoprotein E C-terminal domain

2005 • 34 citations

Studies of the morphology and structure of the plasma lipid transfer particle from the tobacco hornworm, Manduca sexta.

1990 • 33 citations

Thermal Stability of Apolipoprotein A-I in High-Density Lipoproteins by Molecular Dynamics

2009 • 33 citations

Lipophorin structure analyzed by in vitro treatment with lipases.

1991 • 32 citations

The N-terminal Globular Domain and the First Class A Amphipathic Helix of Apolipoprotein A-I Are Important for Lecithin:Cholesterol Acyltransferase Activation and the Maturation of High Density Lipoprotein in Vivo

2001 • 31 citations

Conformation and Lipid Binding of a C-Terminal (198−243) Peptide of Human Apolipoprotein A-I

2007 • 31 citations

Lipid-induced Extension of Apolipoprotein E Helix 4 Correlates with Low Density Lipoprotein Receptor Binding Ability

2006 • 29 citations

Role of Buried Polar Residues in Helix Bundle Stability and Lipid Binding of Apolipophorin III: Destabilization by Threonine 31

2005 • 26 citations

Effect of Diacylglycerol Content on Some Physicochemical Properties of the Insect Lipoprotein, Lipophorin. Correlation with the Binding of Apolipophorin-III

1994 • 25 citations

Structure-guided Protein Engineering Modulates Helix Bundle Exchangeable Apolipoprotein Properties

2003 • 25 citations

Conformational Changes of an Exchangeable Apolipoprotein, Apolipophorin III from Locusta migratoria, at Low pH: Correlation with Lipid Binding

2001 • 23 citations

The use of chemical cross-linking and mass spectrometry to elucidate the tertiary conformation of lipid-bound apolipoprotein A-I

2006 • 23 citations

Interaction of locust apolipophorin III with lipoproteins and phospholipid vesicles: effect of glycosylation

2000 • 23 citations

Fluorescence Spectroscopy of Single Tryptophan Mutants of Apolipophorin-III in Discoidal Lipoproteins of Dimyristoylphosphatidylcholine

2000 • 19 citations

Physical properties of apolipoprotein A-I from the chicken, Gallus domesticus

1993 • 18 citations

Role of Helices and Loops in the Ability of Apolipophorin-III To Interact with Native Lipoproteins and Form Discoidal Lipoprotein Complexes

2003 • 17 citations

Functional similarities of human and chicken apolipoprotein A-I: dependence on secondary and tertiary rather than primary structure

2001 • 17 citations

An N-Terminal Three-Helix Fragment of the Exchangeable Insect Apolipoprotein Apolipophorin III Conserves the Lipid Binding Properties of Wild-Type Protein

2001 • 15 citations

Lipid Binding of the Exchangeable Apolipoprotein Apolipophorin III Induces Major Changes in Fluorescence Properties of Tryptophans 115 and 130

2000 • 12 citations

Interaction of the α-Helices of Apolipophorin III with the Phospholipid Acyl Chains in Discoidal Lipoprotein Particles: A Fluorescence Quenching Study^†

2001 • 12 citations

Replacement of helix 1′ enhances the lipid binding activity of apoE3 N‐terminal domain

2006 • 8 citations

In Vivo Lipoprotein Binding Assay Of The Insect Exchangeable Apolipoprotein, Apolipophorin-Iii

2003 • 3 citations