Apolipoprotein E4 Forms a Molten Globule

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Molten Globule and Protein Folding

1995 • 1,203 citations

The structural basis of protein folding and its links with human disease

2001 • 924 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

1981 • 760 citations

Human apolipoprotein E. The complete amino acid sequence.

1982 • 731 citations

Association of apolipoprotein E polymorphism with outcome after head injury

1997 • 703 citations

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

1991 • 661 citations

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

1995 • 588 citations

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

1994 • 445 citations

Introduction to Dynamic Light Scattering by Macromolecules

1990 • 442 citations

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

1994 • 407 citations

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

2001 • 366 citations

An Introduction to Dynamic Light Scattering by Macromolecules

1991 • 363 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Differences in Stability among the Human Apolipoprotein E Isoforms Determined by the Amino-Terminal Domain

2000 • 301 citations

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.

1994 • 299 citations

Human Apolipoprotein E4 Domain Interaction

1996 • 293 citations

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

1997 • 291 citations

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

1988 • 285 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

Preliminary Report of a Genetic Basis for Cognitive Decline After Cardiac Operations 11The members of the Neurologic Outcome Research Group of the Duke Heart Center are listed in Appendix A.

1997 • 264 citations

Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease

1993 • 249 citations

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

1988 • 229 citations

Three-state analysis of sperm whale apomyoglobin folding

1993 • 226 citations

Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

1996 • 226 citations

Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study.

1994 • 222 citations

Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

1998 • 213 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells

2002 • 167 citations

Thermal unfolding of human high-density apolipoprotein A-1: implications for a lipid-free molten globular state.

1996 • 165 citations

Apolipoprotein E phenotypes in patients with myocardial infarction

1984 • 156 citations

A New Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy Method for the Study of Proteins in Solution

1998 • 135 citations

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins

1998 • 124 citations

Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid

2000 • 95 citations

Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis

2000 • 94 citations

Functional Characterization of Apolipoprotein E Isoforms Overexpressed in Escherichia coli

1999 • 94 citations

Association of APOE ε4 allele with survival in amyotrophic lateral sclerosis

2001 • 94 citations

Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization

2002 • 92 citations

Apolipoprotein E and ALzheimer's Disease: The Tip of the Susceptibility Iceberg

1998 • 82 citations

The Lipid-associated Conformation of the Low Density Lipoprotein Receptor Binding Domain of Human Apolipoprotein E

2000 • 77 citations

Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism

2002 • 76 citations

Apolipoprotein E in the brain and its role in Alzheimer's disease.

1996 • 60 citations

Secondary structures comparison of aquaporin-1 and bacteriorhodopsin: a Fourier transform infrared spectroscopy study of two-dimensional membrane crystals

1997 • 56 citations

Papaya glutamine cyclase, a plant enzyme highly resistant to proteolysis, adopts an all‐β conformation

1998 • 50 citations

Modulation of the lipid binding properties of the N‐terminal domain of human apolipoprotein E3

2001 • 47 citations

Conformational flexibility in the apolipoprotein E amino‐terminal domain structure determined from three new crystal forms: Implications for lipid binding

2000 • 44 citations

Protein Interactions Leading to Conformational Changes Monitored by Limited Proteolysis: Apo Form and Fragments of Horse Cytochromec

2001 • 38 citations

Conformational Changes of an Exchangeable Apolipoprotein, Apolipophorin III from Locusta migratoria, at Low pH: Correlation with Lipid Binding

2001 • 23 citations