Apolipoprotein-mediated cellular cholesterol efflux

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

The plasma lecithin:cholesterol acyltransferase reaction

1968 • 2,415 citations

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

1996 • 2,293 citations

High-Density Lipoprotein — The Clinical Implications of Recent Studies

1989 • 1,565 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

1992 • 852 citations

A molecular theory of lipid—protein interactions in the plasma lipoproteins

1974 • 725 citations

Scavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux

1997 • 694 citations

Early incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein

1988 • 643 citations

Mechanisms and consequences of cellular cholesterol exchange and transfer

1987 • 547 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1996 • 460 citations

Cholesterol transport between cells and high-density lipoproteins

1991 • 451 citations

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.

1995 • 416 citations

Apolipoprotein-mediated removal of cellular cholesterol and phospholipids

1996 • 346 citations

Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.

1991 • 331 citations

Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.

1994 • 315 citations

Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.

1990 • 304 citations

Secondary structures of proteins and peptides in amphiphilic environments. (A review).

1983 • 299 citations

Intracellular cholesterol transport

1997 • 295 citations

Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents

1980 • 279 citations

Plasma membrane caveolae mediate the efflux of cellular free cholesterol

1995 • 273 citations

Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors.

1993 • 271 citations

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol

1991 • 259 citations

Elimination of Cholesterol in Macrophages and Endothelial Cells by the Sterol 27-Hydroxylase Mechanism

1997 • 228 citations

Intracellular Cholesterol Transport and Compartmentation

1995 • 226 citations

Interstitial fluid lipoproteins.

1987 • 223 citations

Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake

1997 • 218 citations

Distribution of apolipoprotein A-IV in human plasma.

1985 • 217 citations

Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting.

1987 • 215 citations

The mechanism of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I and an amphiphilic peptide.

1980 • 204 citations

Decreased Reverse Cholesterol Transport from Tangier Disease Fibroblasts

1997 • 203 citations

Evidence for a lipoprotein carrier in human plasma catalyzing sterol efflux from cultured fibroblasts and its relationship to lecithin:cholesterol acyltransferase.

1981 • 197 citations

Cyclic AMP Induces Apolipoprotein E Binding Activity and Promotes Cholesterol Efflux from a Macrophage Cell Line to Apolipoprotein Acceptors

1996 • 196 citations

Intracellular cholesterol transport.

1992 • 196 citations

Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface.

1987 • 193 citations

Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility.

1985 • 189 citations

Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides

1995 • 188 citations

Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol.

1994 • 187 citations

The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein.

1986 • 186 citations

Mechanism of cholesterol efflux from cells. Effects of acceptor structure and concentration.

1982 • 184 citations

Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

1996 • 180 citations

A plasma lipoprotein containing only apolipoprotein Eand with gamma mobility on electrophoresis releases cholesterol fromcells.

1994 • 177 citations

Lecithin: cholesterol acyltransferase deficiency and fish-eye disease

1991 • 171 citations

Phospholipid transfer protein mediated conversion of high density lipoproteins generates preβ1-HDL

1996 • 169 citations

Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells.

1992 • 157 citations

Erythrocyte metabolism. III. Relationship of energy metabolism and serum factors to the osmotic fragility following incubation

1962 • 155 citations

PHYLOGENIES CONSTRAINED BY THE CROSSOVER PROCESS AS ILLUSTRATED BY HUMAN HEMOGLOBINS AND A THIRTEEN-CYCLE, ELEVEN-AMINO-ACID REPEAT IN HUMAN APOLIPOPROTEIN A-I

1977 • 152 citations

Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apo A-I from HDL and subsequent formation of discoidal HDL

1992 • 150 citations

High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts.

1991 • 150 citations

Nonenzymatic Glycosylation of HDL and Impaired HDL-Receptor–Mediated Cholesterol Efflux

1991 • 149 citations

Apolipoprotein E Produced by Human Monocyte-derived Macrophages Mediates Cholesterol Efflux That Occurs in the Absence of Added Cholesterol Acceptors

1996 • 147 citations

The Effect of High Density Lipoprotein Phospholipid Acyl Chain Composition on the Efflux of Cellular Free Cholesterol

1995 • 146 citations

Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversible binding at the cell surface without internalization.

1987 • 141 citations

In vitro modulation of the apolipoprotein composition of high density lipoprotein. Displacement of apolipoprotein A-I from high density lipoprotein by apolipoprotein A-II.

1980 • 138 citations

Effect of lipid particle size on association of apolipoproteins with lipid.

1983 • 134 citations

Fluid absorption in isolated perfused colonic crypts.

1995 • 133 citations

Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.

1992 • 129 citations

Dissociation of lipid-free apolipoprotein A-I from high density lipoproteins.

1994 • 129 citations

Effects of Acceptor Particle Size on the Efflux of Cellular Free Cholesterol

1995 • 128 citations

Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells.

1993 • 128 citations

Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice

1995 • 128 citations

The Lipids and Lipoproteins of Human Peripheral Lymph, with Observations on the Transport of Cholesterol from Plasma and Tissues into Lymph

1973 • 127 citations

Serum Cholesterol Esterification in Liver Disease

1970 • 125 citations

Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to the cell surface.

1987 • 124 citations

Binding of high density lipoprotein to cultured fibroblasts after chemical alteration of apoprotein amino acid residues.

1986 • 122 citations

Regulation of Cellular Cholesterol Efflux by Lecithin:Cholesterol Acyltransferase Reaction through Nonspecific Lipid Exchange

1996 • 121 citations

HDL-Mediated Efflux of Intracellular Cholesterol Is Impaired in Fibroblasts From Tangier Disease Patients

1995 • 120 citations

Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT

1995 • 120 citations

Repeated helical pattern in apolipoprotein-A-I

1977 • 120 citations

Apolipoprotein A-I-cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles.

1993 • 118 citations

Behavior of human apolipoprotein E in aqueous solutions and at interfaces.

1985 • 115 citations

Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion

1997 • 111 citations

Regulation of the concentration of pre.beta. high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase activity

1992 • 110 citations

Quantitation of pre.beta.-HDL-dependent and nonspecific components of the total efflux of cellular cholesterol and phospholipid

1993 • 107 citations

Evidence for high density lipoproteins as the major apolipoprotein A-IV-containing fraction in normal human serum.

1989 • 104 citations

High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages.

1989 • 103 citations

Characterization of dog peripheral lymph lipoproteins: the presence of a disc-shaped "nascent" high density lipoprotein.

1983 • 99 citations

Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-.beta.-high-density lipoprotein pathway

1992 • 98 citations

Evidence for the distribution of apolipoprotein E between lipoprotein classes in human normocholesterolemic plasma and for the origin of unassociated apolipoprotein E (Lp-E).

1984 • 97 citations

Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells.

1993 • 94 citations

Human apolipoprotein A-IV: displacement from the surface of triglyceride-rich particles by HDL2-associated C-apoproteins.

1985 • 92 citations

The influence of cellular and lipoprotein cholesterol contents on the flux of cholesterol between fibroblasts and high density lipoprotein.

1988 • 90 citations

Studies on the rate of efflux of cholesterol from cultured human skin fibroblasts.

1981 • 87 citations

Possible role of protein phosphorylation in the mitogenic effect of high density lipoproteins on cultured vascular endothelial cells.

1986 • 85 citations

Pig plasma phospholipid transfer protein facilitates HDL interconversion.

1995 • 77 citations

Chain length-function correlation of amphiphilic peptides. Synthesis and surface properties of a tetratetracontapeptide segment of apolipoprotein A-I.

1980 • 76 citations

Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools

1995 • 76 citations

The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein.

1994 • 75 citations

Cholesterol Efflux, Cholesterol Esterification, and Cholesteryl Ester Transfer by LpA-I and LpA-I/A-II in Native Plasma

1995 • 74 citations

Monensin and Brefeldin A Inhibit High Density Lipoprotein- mediated Cholesterol Efflux from Cholesterol-enriched Cells

1995 • 74 citations

Activation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids.

1985 • 73 citations

Selective Inhibition of Free Apolipoprotein-Mediated Cellular Lipid Efflux by Probucol

1996 • 73 citations

Selective Down-Regulation by Protein Kinase C Inhibitors of Apolipoprotein-Mediated Cellular Cholesterol Efflux in Macrophages

1997 • 73 citations

Presence and Formation of ‘Free Apolipoprotein A-I–Like’ Particles in Human Plasma

1995 • 72 citations

Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation

1990 • 72 citations

α‐Helical requirements for free apolipoproteins to generate HDL and to induce cellular lipid efflux

1992 • 67 citations

Independent Regulation of Cholesterol Incorporation into Free Apolipoprotein-mediated Cellular Lipid Efflux in Rat Vascular Smooth Muscle Cells

1995 • 65 citations

Apolipoprotein A-I Structural Modification and the Functionality of Reconstituted High Density Lipoprotein Particles in Cellular Cholesterol Efflux

1996 • 60 citations

Oxidative Tyrosylation of HDL Enhances the Depletion of Cellular Cholesteryl Esters by a Mechanism Independent of Passive Sterol Desorption

1996 • 59 citations

HDL₃Stimulates Multiple Signaling Pathways in Human Skin Fibroblasts

1995 • 58 citations

Platelet-derived growth factor induces c-fms and scavenger receptor genes in vascular smooth muscle cells.

1992 • 57 citations

Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus

1996 • 57 citations

Mechanism of transfer of LDL-derived free cholesterol to HDL subfractions in human plasma

1990 • 56 citations

Modulation of Cholesterol Efflux from Fu5AH Hepatoma Cells by the Apolipoprotein Content of High Density Lipoprotein Particles.

1995 • 56 citations

Nonenzymatic glycosylation of HDL and impaired HDL-receptor-mediated cholesterol efflux

1991 • 56 citations

Characterization of dog prenodal peripheral lymph lipoproteins. Evidence for the peripheral formation of lipoprotein-unassociated apoA-I with slow pre-beta electrophoretic mobility.

1988 • 55 citations

Expression of human lecithin:cholesterol acyltransferase in transgenic mice: effects on cholesterol efflux, esterification, and transport

1997 • 55 citations

Lecithin:cholesterol acyltransferase reaction on cellular lipid released by free apolipoprotein-mediated efflux

1995 • 54 citations

Role of Free Apolipoprotein A-I in Cholesterol Efflux

1997 • 54 citations

Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells

1993 • 52 citations

Effects of membrane lipid composition on the kinetics of cholesterol exchange between lipoproteins and different species of red blood cells

1990 • 51 citations

Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms.

1996 • 47 citations

Human lymphedema fluid lipoproteins: particle size, cholesterol and apolipoprotein distributions, and electron microscopic structure.

1985 • 45 citations

Triglyceride transfer is required for net cholesteryl ester transfer between lipoproteins in plasma by lipid transfer protein. Evidence for a hetero-exchange transfer mechanism demonstrated by using novel monoclonal antibodies.

1994 • 43 citations

Resistance of smooth muscle cells to assembly of high density lipoproteins with extracellular free apolipoproteins and to reduction of intracellularly accumulated cholesterol.

1992 • 40 citations

Efflux of Newly Synthesized Cholesterol and Biosynthetic Sterol Intermediates from Cells

1995 • 37 citations

Identification of specific amphipathic alpha-helical sequence of human apolipoprotein A-IV involved in lecithin:cholesterol acyltransferase activation.

1994 • 37 citations

Limited proteolysis of high density lipoprotein abolishes its interaction with cell-surface binding sites that promote cholesterol efflux

1997 • 36 citations

Cell-surface binding sites for high density lipoproteins do not mediate efflux of cholesterol from human fibroblasts in tissue culture.

1988 • 36 citations

The solid phase synthesis of a protein activator for lecithin-cholesterol acyltransferase corresponding to human plasma apoC-I.

1976 • 36 citations

Association of Apolipoprotein E with the Low Density Lipoprotein Receptor: Demonstration of Its Co-Operativity on Lipid Microemulsion Particles1

1989 • 32 citations

Involvement of a cellular surface factor(s) in lipid-free apolipoprotein-mediated cellular cholesterol efflux

1995 • 32 citations

Mechanism of Action of Lipoprotein Lipase on Triolein Particles: Effect of Apolipoprotein C-II1

1984 • 31 citations

Efflux of intracellular versus plasma membrane cholesterol in HepG2 cells: different availability and regulation by apolipoprotein A-I.

1995 • 30 citations

Cellular localization and characterization of proteins that bind high density lipoprotein.

1992 • 26 citations

A little more information about aggravation of probucol-induced HDL-reduction by clofibrate

1988 • 23 citations

Modulation of Cholesterol Microenvironment with Apolipoproteins Induced by the Presence of Cholesteryl Ester in Lipid Microemulsion1

1988 • 20 citations

Effect of phospholipid fatty acid composition of endothelial cells on cholesterol efflux rates.

1992 • 20 citations

Structural relationships between nascent apoA-I-containing particles that are extracellularly assembled in cell culture

1996 • 20 citations

A Japanese family with high density lipoprotein deficiency

1983 • 16 citations

Cholesterol esterification by lecithin-cholesterol acyltransferase in A-I-free plasma

1988 • 15 citations

Decrease in high density lipoprotein binding sites is associated with decrease in intracellular cholesterol efflux in dedifferentiated aortic smooth muscle cells

1994 • 14 citations

Untersuchung der Lecithin-Cholesterin-Acyltransferase-Aktivit�t im Serum von drei Patienten mit Tangier-Krankheit (Hyp-alpha-Lipoprotein�mie)

1973 • 10 citations

Human peripheral lymph lipoproteins are enriched in sphingomyelin

1992 • 9 citations

Elevation of cyclic AMP in human skin fibroblasts results in increased capacity for HDL binding

1996 • 4 citations