Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Molten Globule and Protein Folding

1995 • 1,203 citations

Alzheimer’s Dementia

1985 • 1,042 citations

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

2000 • 896 citations

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

2006 • 890 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Amyloid fibrils from muscle myoglobin

2001 • 797 citations

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

1991 • 661 citations

Apolipoprotein E structure: insights into function

2006 • 524 citations

Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus

2006 • 452 citations

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

1994 • 445 citations

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

1994 • 407 citations

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

2004 • 370 citations

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

2003 • 328 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

Differences in Stability among the Human Apolipoprotein E Isoforms Determined by the Amino-Terminal Domain

2000 • 301 citations

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.

1994 • 299 citations

Human Apolipoprotein E4 Domain Interaction

1996 • 293 citations

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

1990 • 289 citations

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

1988 • 285 citations

Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

2005 • 262 citations

Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

2005 • 255 citations

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

1988 • 229 citations

Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease

2004 • 214 citations

Apolipoprotein E4 Forms a Molten Globule

2002 • 195 citations

Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein E

2001 • 183 citations

Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells

2002 • 167 citations

Is Alzheimer's disease an apolipoprotein E amyloidosis?

1995 • 156 citations

Glutamate–glutamine cycling in Alzheimer's disease

2006 • 153 citations

Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity

1991 • 99 citations

Amino-terminal Domain Stability Mediates Apolipoprotein E Aggregation into Neurotoxic Fibrils

2006 • 97 citations

Modulation of Apolipoprotein E Structure by Domain Interaction

2005 • 87 citations

Effect of Domain Interaction on Apolipoprotein E Levels in Mouse Brain

2005 • 82 citations

Apolipoprotein E4 Domain Interaction Occurs in Living Neuronal Cells as Determined by Fluorescence Resonance Energy Transfer

2004 • 77 citations

Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice

2008 • 68 citations

Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins

1998 • 40 citations

Engineering Conformational Destabilization into Mouse Apolipoprotein E

2005 • 39 citations