Molecular basis of exchangeable apolipoprotein function

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

1992 • 852 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

1991 • 661 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation

1997 • 417 citations

Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.

1977 • 380 citations

Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

1980 • 372 citations

Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.

1980 • 365 citations

Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.

1980 • 359 citations

Abnormal in vivo metabolism of apolipoprotein E4 in humans.

1986 • 343 citations

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module

1997 • 329 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

[32] Reconstitution of high-density lipoproteins

1986 • 316 citations

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.

1985 • 315 citations

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

1989 • 307 citations

The Amphipathic α Helix: A Multifunctional Structural Motif in Plasma Apolipoproteins

1994 • 307 citations

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.

1979 • 303 citations

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.

1994 • 299 citations

Human Apolipoprotein E4 Domain Interaction

1996 • 293 citations

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

1990 • 289 citations

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

1988 • 285 citations

The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.

1983 • 276 citations

Isolation and characterization of the human apolipoprotein A-I gene.

1983 • 243 citations

Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.

1990 • 239 citations

An overview of reverse cholesterol transport.

1998 • 238 citations

Molecular structure of an apolipoprotein determined at 2.5-.ANG. resolution

1991 • 234 citations

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

1988 • 229 citations

Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation.

1989 • 200 citations

Lipophorin: The Structure of an Insect Lipoprotein and Its Role in Lipid Transport in Insects

1994 • 195 citations

Lipid Transport Biochemistry and Its Role in Energy Production

2000 • 179 citations

Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.

1984 • 178 citations

Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization

1993 • 165 citations

Apolipoprotein E mediates uptake of Sf 100-400 hypertriglyceridemic very low density lipoproteins by the low density lipoprotein receptor pathway in normal human fibroblasts.

1983 • 162 citations

Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism

1992 • 160 citations

Structural models of human apolipoprotein A-I

1995 • 145 citations

The role of apolipoprotein AI domains in lipid binding

1996 • 140 citations

Predicting the structure of apolipoprotein A-I in reconstituted high-density lipoprotein disks

1997 • 138 citations

The Structure of Human Lipoprotein A-I

1999 • 130 citations

Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia

1996 • 123 citations

Apolipoprotein A-I domains involved in lecithin-cholesterol acyltransferase activation. Structure:function relationships.

1993 • 123 citations

Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity

1995 • 115 citations

Properties of an N-terminal Proteolytic Fragment of Apolipoprotein AI in Solution and in Reconstituted High Density Lipoproteins

1995 • 110 citations

Apolipoprotein-mediated cellular cholesterol efflux

1998 • 108 citations

Truncation of the Amino Terminus of Human Apolipoprotein A-I Substantially Alters Only the Lipid-Free Conformation

1997 • 108 citations

Primary structure and comparative sequence analysis of an insect apolipoprotein. Apolipophorin-III from Manduca sexta.

1987 • 107 citations

Binding of insect apolipophorin III to dimyristoylphosphatidylcholine vesicles. Evidence for a conformational change.

1994 • 104 citations

Physical and surface properties of insect apolipophorin III.

1986 • 103 citations

Mechanisms of high density lipoprotein-mediated efflux of cholesterol from cell plasma membranes

1998 • 101 citations

The role of apolipophorin III in in vivo lipoprotein interconversions in adult Manduca sexta.

1987 • 101 citations

The Carboxyl-terminal Hydrophobic Residues of Apolipoprotein A-I Affect Its Rate of Phospholipid Binding and Its Association with High Density Lipoprotein

1997 • 95 citations

Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein

1994 • 93 citations

Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E

1999 • 91 citations

Structure of the Asn-linked oligosaccharides of apolipophorin III from the insect Locusta migratoria. Carbohydrate-linked 2-aminoethylphosphonate as a constituent of a glycoprotein

1993 • 90 citations

The Low Density Lipoprotein Receptor Active Conformation of Apolipoprotein E

1998 • 90 citations

Structural Analysis of Apolipoprotein A-I: Limited Proteolysis of Methionine-Reduced and -Oxidized Lipid-Free and Lipid-Bound Human Apo A-I

1997 • 85 citations

Prevention of phospholipase‐C induced aggregation of low density lipoprotein by amphipathic apolipoproteins

1993 • 82 citations

The Lipid-Free Structure of Apolipoprotein A-I: Effects of Amino-Terminal Deletions

1998 • 76 citations

Phospholipid binding and lecithin-cholesterol acyltransferase activation properties of apolipoprotein A-I mutants

1995 • 76 citations

Structural Analysis of Apolipoprotein A-I: Effects of Amino- and Carboxy-Terminal Deletions on the Lipid-Free Structure

1998 • 74 citations

Conformational, thermodynamic, and stability properties of Manduca sexta apolipophorin III.

1993 • 74 citations

The Hydrophobic Face Orientation of Apolipoprotein A-I Amphipathic Helix Domain 143–164 Regulates Lecithin:Cholesterol Acyltransferase Activation

1998 • 68 citations

Low concentrations of diacylglycerol promote the binding of apolipophorin III to a phospholipid bilayer: a surface plasmon resonance spectroscopy study.

1995 • 68 citations

Disulfide Bond Engineering to Monitor Conformational Opening of Apolipophorin III During Lipid Binding

1996 • 68 citations

Adipokinetic hormone-induced lipolysis in the fat body of an insect, Manduca sexta: synthesis of sn-1,2-diacylglycerols.

1997 • 66 citations

Apolipophorin III is dramatically up‐regulated during the programmed death of insect skeletal muscle and neurons

1995 • 62 citations

Mechanism of dissociation of human apolipoprotein A-I from complexes with dimyristoylphosphatidylcholine as studied by guanidine hydrochloride denaturation

1982 • 62 citations

Hydrogen/Deuterium Exchange Kinetics of Apolipophorin-III in Lipid-free and Phospholipid-bound States

1996 • 62 citations

High yield overexpression and characterization of human recombinant proapolipoprotein A-I.

1996 • 61 citations

Lipolysis exposes unreactive endogenous apolipoprotein E-3 in human and rat plasma very low density lipoprotein.

1991 • 61 citations

Effect of Apolipoprotein A-I Lipidation on the Formation and Function of Pre-β and α-Migrating LpA-I Particles

1999 • 58 citations

Insight into Lipid Surface Recognition and Reversible Conformational Adaptations of an Exchangeable Apolipoprotein by Multidimensional Heteronuclear NMR Techniques

1997 • 56 citations

Alignment of the Apolipophorin-III α-Helices in Complex with Dimyristoylphosphatidylcholine.

1995 • 53 citations

Uptake of chylomicron remnants by the liver: further evidence for the modulating role of phospholipids.

1988 • 53 citations

Comparison of Lipid-Binding and Lecithin:Cholesterol Acyltransferase Activation of the Amino- and Carboxyl-Terminal Domains of Human Apolipoprotein E3

1995 • 52 citations

Factors Affecting the Stability and Conformation of Locusta migratoria Apolipophorin III

1994 • 52 citations

Exchangeable apolipoproteins of insects share a common structural motif.

1994 • 50 citations

Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function

1988 • 49 citations

Alteration in Apolipoprotein A-I 22-Mer Repeat Order Results in a Decrease in Lecithin:Cholesterol Acyltransferase Reactivity

1997 • 49 citations

A molecular trigger of lipid binding-induced opening of a helix bundle exchangeable apolipoprotein

1999 • 48 citations

Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E

1998 • 46 citations

Characterization of human apolipoprotein A-I expressed in Escherichia coli

1997 • 43 citations

High level secretion of wild-type and mutant forms of human proapoA-I using baculovirus-mediated Sf-9 cell expression

1996 • 40 citations

The Lipid Binding Activity of the Exchangeable Apolipoprotein Apolipophorin-III Correlates with the Formation of a Partially Folded Conformation

1998 • 40 citations

Amphipathic α-Helix Bundle Organization of Lipid-Free Chicken Apolipoprotein A-I

1999 • 40 citations

Human Low Density Lipoprotein Receptor Fragment

1997 • 39 citations

Interaction of an Exchangeable Apolipoprotein with Phospholipid Vesicles and Lipoprotein Particles

1999 • 39 citations

Bacterial expression and site-directed mutagenesis of a functional recombinant apolipoprotein.

1995 • 39 citations

Recombinant locust apolipophorin III: characterization and NMR spectroscopy

1998 • 32 citations

Importance of Central α-Helices of Human Apolipoprotein A-I in the Maturation of High-Density Lipoproteins

1998 • 32 citations

Deletion of Central α-Helices in Human Apolipoprotein A-I: Effect on Phospholipid Association

1997 • 29 citations

Role of the Arg123–Tyr166 Paired Helix of Apolipoprotein A-I in Lecithin:Cholesterol Acyltransferase Activation

1997 • 29 citations

Identification and localization of two distinct microenvironments for the diacylglycerol component of lipophorin particles by 13C NMR

1995 • 28 citations

Conversion of human low density lipoprotein into a very low density lipoprotein-like particle in vitro.

1992 • 27 citations

Hepatic uptake of phospholipid-depleted chylomicrons in vivo. Comparison with the uptake of chylomicron remnants

1981 • 26 citations

Effect of Diacylglycerol Content on Some Physicochemical Properties of the Insect Lipoprotein, Lipophorin. Correlation with the Binding of Apolipophorin-III

1994 • 25 citations

High density lipoproteins and reverse cholesterol transport: Lessons from mutations

1998 • 25 citations

Expression and Characterization of a Truncated, Soluble, Low-Density Lipoprotein Receptor

1996 • 24 citations

Effects of Deletion of the Carboxyl-terminal Domain of ApoA-I or of Its Substitution with Helices of ApoA-II on in Vitro and in Vivo Lipoprotein Association

1996 • 23 citations

Structural studies of lipoproteins and their apolipoprotein components

1996 • 23 citations

Role of Glycosylation in the Lipid-Binding Activity of the Exchangeable Apolipoprotein, Apolipophorin-III

1998 • 22 citations

Fusion of low density lipoproteins with cholesterol ester-phospholipid microemulsions. Prevention of particle fusion by apolipoprotein A-I.

1985 • 21 citations

Fluorescence Studies of Exchangeable Apolipoprotein-Lipid Interactions

1998 • 20 citations

Spectroscopic and Lipid Binding Studies on the Amino and Carboxyl Terminal Fragments of Locusta migratoria Apolipophorin III

1995 • 18 citations

Structural and Binding Characteristics of the Carboxyl Terminal Fragment of Apolipophorin III from Manduca sexta

1994 • 18 citations

Physical properties of apolipoprotein A-I from the chicken, Gallus domesticus

1993 • 18 citations

Role of the Carboxy‐Terminal Domain of Human Apolipoprotein AI in High‐Density‐Lipoprotein Metabolism

1997 • 15 citations

Interhelical contacts are required for the helix bundle fold of apolipophorin III and its ability to interact with lipoproteins

1998 • 12 citations

Fluorescence Studies of Lipid Association-Induced Conformational Adaptations of an Exchangeable Amphipathic Apolipoprotein

1996 • 11 citations

Protein-lipid interactions of apolipophorin-III, a model exchangeable amphipathic apolipoprotein

1997 • 10 citations

NMR evidence for a conformational adaptation of apolipophorin III upon lipid association

1998 • 9 citations

Spectroscopic characterization of the conformational adaptability of Bombyx mori apolipophorin III

2000 • 9 citations

NMR evidence for a conformational adaptation of apolipophorin III upon lipid association

1998 • 9 citations

Secretion and processing of apolipoprotein A-I in the avian sciatic nerve during development

1996 • 6 citations