Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

2000 • 1,527 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Modulation of Akt kinase activity by binding to Hsp90

2000 • 942 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

2000 • 784 citations

Tumour suppression by the human von Hippel-Lindau gene product

1995 • 705 citations

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

2002 • 633 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Induction of HIF-1alpha in response to hypoxia is instantaneous.

2001 • 507 citations

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

1997 • 501 citations

Induction of HIF–1α in response to hypoxia is instantaneous

2001 • 416 citations

Development of a hypoxia-responsive vector for tumor-specific gene therapy

2000 • 262 citations

Heat Induction of the Unphosphorylated Form of Hypoxia-inducible Factor-1α Is Dependent on Heat Shock Protein-90 Activity

2002 • 153 citations

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells11Abbreviations: EPO, erythropoietin; VEGF, vascular endothelial growth factor; HIF, hypoxia-inducible factor; NO, nitric oxide; NOS, nitric oxide synthase; CO, carbon monoxide; sGC, soluble guanylate cyclase; cGMP, cyclic GMP; YC-1, 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole; SNP, sodium nitroprusside; ODQ, 1H-(1,2,4)oxadiazole (4,3a)quinoxatin-1-one; MB, methylene blue…

2001 • 146 citations

Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways

2001 • 127 citations

Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development

1999 • 117 citations