Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

2000 • 1,527 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

HIF-1, O2, and the 3 PHDs

2001 • 917 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

1999 • 834 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

2001 • 748 citations

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

2001 • 504 citations

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1999 • 377 citations

The von Hippel–Lindau tumor suppressor protein

2001 • 208 citations

Characterization and comparative analysis of the EGLN gene family

2001 • 143 citations

Software and database for the analysis of mutations in the VHL gene

1998 • 142 citations

Structure of proline 3‐hydroxylase

2001 • 107 citations

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1999 • 105 citations

Ciné-malaise

2001 • 1 citations