Control of the eukaryotic cell cycle by MAP kinase signaling pathways

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1999 • 1,152 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

1996 • 769 citations

Mitosis in transition

1994 • 745 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1999 • 662 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Histone acetylases and deacetylases in cell proliferation

1999 • 598 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Control of cell cycle progression by c-Jun is p53 dependent

1999 • 562 citations

Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases

1999 • 518 citations

Control of the yeast cell cycle by the Cdc28 protein kinase

1993 • 502 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Assembly of cyclin D-dependent kinase and titration of p27 ^Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

1998 • 497 citations

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast

1995 • 474 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo

1999 • 449 citations

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

1998 • 446 citations

Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase

1996 • 445 citations

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

1996 • 419 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

1997 • 409 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

1996 • 365 citations

The ras Oncogenes Increase the Intrinsic Resistance of NIH 3T3 Cells to Ionizing Radiation

1988 • 361 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

1995 • 356 citations

MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases?

1997 • 318 citations

The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways

1998 • 302 citations

Growth factor activation of MAP kinase requires cell adhesion

1997 • 301 citations

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast

1993 • 290 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

The cdc25 M-phase inducer: An unconventional protein phosphatase

1992 • 266 citations

Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

1998 • 264 citations

Direct Inhibition of the Yeast Cyclin-Dependent Kinase Cdc28-Cln by Far1

1994 • 258 citations

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.

1996 • 227 citations

Regulation of carbamoyl phosphate synthetase by MAP kinase

2000 • 220 citations

α5β1 Integrin Controls Cyclin D1 Expression by Sustaining Mitogen-activated Protein Kinase Activity in Growth Factor-treated Cells

1999 • 218 citations

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

1997 • 207 citations

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

1997 • 199 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases

1997 • 192 citations

Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK

1997 • 191 citations

MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway

1999 • 187 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Discrete Roles of the Spc1 Kinase and the Atf1 Transcription Factor in the UV Response of Schizosaccharomyces pombe

1997 • 176 citations

Mitogen-activated protein kinase kinase activity is required for the G ₂ /M transition of the cell cycle in mammalian fibroblasts

1999 • 175 citations

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes.

1993 • 174 citations

Ras Activity Late in G₁ Phase Required for p27^kip1 Downregulation, Passage through the Restriction Point, and Entry into S Phase in Growth Factor-Stimulated NIH 3T3 Fibroblasts

1997 • 169 citations

Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase

1997 • 160 citations

Activation of Raf by ionizing radiation

1996 • 158 citations

Nuclear Shuttling of Yeast Scaffold Ste5 Is Required for Its Recruitment to the Plasma Membrane and Activation of the Mating MAPK Cascade

1999 • 156 citations

Anchorage-Dependent Transcription of the Cyclin A Gene

1996 • 136 citations

Regulation of P21cip1 Expression by Growth Factors and the Extracellular Matrix Reveals a Role for Transient ERK Activity in G1 Phase

1999 • 135 citations

Contribution of the ERK5/MEK5 Pathway to Ras/Raf Signaling and Growth Control

1999 • 134 citations

Mitogen-activated Protein Kinase Kinase 2 Activation Is Essential for Progression through the G2/M Checkpoint Arrest in Cells Exposed to Ionizing Radiation

1999 • 134 citations

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1997 • 131 citations

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1999 • 121 citations

Ste12 and Mcm1 Regulate Cell Cycle-Dependent Transcription of FAR1

1996 • 113 citations

Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events

1996 • 96 citations

Pheromone-Dependent G₁ Cell Cycle Arrest Requires Far1 Phosphorylation, but May Not Involve Inhibition of Cdc28-Cln2 Kinase, In Vivo

1998 • 92 citations

Tyrosine 763 of the Murine Granulocyte Colony-Stimulating Factor Receptor Mediates Ras-Dependent Activation of the JNK/SAPK Mitogen-Activated Protein Kinase Pathway

1997 • 86 citations

Cell Cycle Arrest and Reversion of Ras-Induced Transformation by a Conditionally Activated Form of Mitogen-Activated Protein Kinase Kinase Kinase 3

1999 • 86 citations

Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades

1999 • 85 citations

SAPKs and transcription factors do the nucleocytoplasmic tango: Figure 1.

1998 • 77 citations

Complexes of p21RAS with JUN N-terminal kinase and JUN proteins.

1995 • 74 citations

Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway

1999 • 65 citations

FAR1 and the G₁ Phase Specificity of Cell Cycle Arrest by Mating Factor in Saccharomyces cerevisiae

1995 • 61 citations

Fus3p and Kss1p Control G1 Arrest in Saccharomyces cerevisiae Through a Balance of Distinct Arrest and Proliferative Functions That Operate in Parallel With Far1p

1999 • 49 citations