Multiscale Modeling of Form and Function

Matrix Elasticity Directs Stem Cell Lineage Specification

2006 • 12,751 citations

Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

2004 • 4,004 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Environmental sensing through focal adhesions

2008 • 2,342 citations

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

2007 • 2,289 citations

Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension

2003 • 1,555 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Stretching Single Talin Rod Molecules Activates Vinculin Binding

2009 • 1,415 citations

The genome of the social amoeba Dictyostelium discoideum

2005 • 1,300 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

2008 • 1,102 citations

Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer

2006 • 1,075 citations

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation

2004 • 978 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

The Trichoplax genome and the nature of placozoans

2008 • 874 citations

Directed movements and selective adhesion of embryonic amphibian cells

1955 • 869 citations

The differential adhesion hypothesis: a direct evaluation

2004 • 851 citations

Traction Dynamics of Filopodia on Compliant Substrates

2008 • 846 citations

Emergent patterns of growth controlled by multicellular form and mechanics

2005 • 822 citations

β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

2002 • 772 citations

Tensile forces govern germ-layer organization in zebrafish

2008 • 766 citations

Mechanically Activated Integrin Switch Controls α ₅ β ₁ Function

2009 • 690 citations

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.

1995 • 593 citations

Basement Membrane Proteins: Structure, Assembly, and Cellular Interactions

1992 • 584 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

The Architecture of Life

1998 • 545 citations

Role of polysaccharides in Pseudomonas aeruginosa biofilm development

2007 • 544 citations

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

2008 • 488 citations

The Unicellular Ancestry of Animal Development

2004 • 484 citations

How we are shaped: The biomechanics of gastrulation

2003 • 484 citations

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

2008 • 463 citations

Evolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins

2003 • 424 citations

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

2008 • 405 citations

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

2003 • 389 citations

Forced Unfolding of Proteins Within Cells

2007 • 371 citations

Genetic and Epigenetic Regulation of the FLO Gene Family Generates Cell-Surface Variation in Yeast

2004 • 361 citations

The mechanisms and dynamics of αvβ3 integrin clustering in living cells

2005 • 332 citations

Integrin-dependent actomyosin contraction regulates epithelial cell scattering

2005 • 319 citations

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

2008 • 316 citations

Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

2002 • 315 citations

Type IV collagens regulate BMP signalling in Drosophila

2008 • 315 citations

Mathematical Modeling of Planar Cell Polarity to Understand Domineering Nonautonomy

2005 • 302 citations

Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types

2007 • 277 citations

Deciphering skeletal patterning: clues from the limb

2003 • 257 citations

Morphogen Control of Wing Growth through the Fat Signaling Pathway

2008 • 251 citations

Topobiology: An Introduction To Molecular Embryology

1988 • 244 citations

Planar cell polarity: one or two pathways?

2007 • 216 citations

Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

2002 • 211 citations

RPTP-α acts as a transducer of mechanical force on αv/β3-integrin–cytoskeleton linkages

2003 • 199 citations

Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation

2008 • 184 citations

Spatial distribution and functional significance of activated vinculin in living cells

2005 • 182 citations

The echinoderm adhesome

2006 • 168 citations

Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge

1997 • 160 citations

Adherens junctions and β-catenin-mediated cell signalling in a non-metazoan organism

2000 • 138 citations

Cell–cell adhesion via the ECM: integrin genetics in fly and worm

2000 • 129 citations

On the origin of Metazoan adhesion receptors: cloning of integrin alpha subunit from the sponge Geodia cydonium

1997 • 122 citations

Polarity and Differential Inheritance—Universal Attributes of Life?

2008 • 121 citations

Modeling and computational analysis of EGF receptor-mediated cell communication inDrosophilaoogenesis

2002 • 118 citations

Evolution of the Integrin α and β Protein Families

2001 • 111 citations

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

2005 • 103 citations

An adhesion molecule in free‐living Dictyostelium amoebae with integrin β features

2006 • 102 citations

The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo

2008 • 101 citations

Interplay of mechanical deformation and patterned gene expression in developing embryos

2004 • 99 citations

Distinct domains of the Candida albicans adhesin Eap1p mediate cell–cell and cell–substrate interactions

2008 • 87 citations

Mechanical Asymmetry in the Embryonic Chick Heart During Looping

2003 • 84 citations

Evolution of collagen-based adhesion systems

2008 • 82 citations

Cell-Cell Adhesion in the Cnidaria: Insights Into the Evolution of Tissue Morphogenesis

2008 • 82 citations

Paxillin is required for cell-substrate adhesion, cell sorting and slug migration duringDictyosteliumdevelopment

2005 • 70 citations

Demosponge and Sea Anemone Fibrillar Collagen Diversity Reveals the Early Emergence of A/C Clades and the Maintenance of the Modular Structure of Type V/XI Collagens from Sponge to Human

2008 • 63 citations

EGF Signaling and Ommatidial Rotation in the Drosophila Eye

2003 • 62 citations

Evidence for the evolution of tenascin and fibronectin early in the chordate lineage

2008 • 61 citations

Fibronectin matrix composition and organization can regulate cell migration during amphibian development

2000 • 60 citations

Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility

2004 • 58 citations

Regulation of cell–cell adhesion during Dictyostelium development

2004 • 49 citations

Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye

2008 • 49 citations

Involvement of Sib Proteins in the Regulation of Cellular Adhesion in Dictyostelium discoideum

2008 • 38 citations

Comparison of molecular mechanisms mediating cell contact phenomena in model developmental systems: an exploration of universality

2004 • 37 citations

Unexpected diversity of cnidarian integrins: expression during coral gastrulation

2008 • 30 citations

Spatial distribution of VEGF isoforms and chemotactic signals in the vicinity of a tumor

2008 • 15 citations

Embryonic Development: Toward a Synthesis: Topobiology . An Introduction to Molecular Embryology. Gerald M. Edelman. Basic Books, New York, 1988. xvi, 240 pp., illus. $21.95.

1989 • 10 citations