Cell–cell adhesion via the ECM: integrin genetics in fly and worm

Integrin Signaling

1999 • 3,705 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans

1994 • 1,075 citations

Vinculin knockout results in heart and brain defects during embryonic development

1998 • 511 citations

Absence of integrin α7 causes a novel form of muscular dystrophy

1997 • 435 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Muscle cell attachment in Caenorhabditis elegans.

1991 • 371 citations

Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations

1994 • 332 citations

Integrin-mediated short-term memory in Drosophila

1998 • 283 citations

The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

1987 • 263 citations

Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.

1993 • 251 citations

Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization.

1985 • 244 citations

Microtubule Actin Cross-Linking Factor (Macf)

1999 • 215 citations

Biology and function of hemidesmosomes

1999 • 210 citations

Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.

1995 • 209 citations

A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans

1999 • 208 citations

A role for integrin in the formation of sarcomeric cytoarchitecture

1990 • 207 citations

Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans

1994 • 197 citations

Neuronal Migrations and Axon Fasciculation Are Disrupted in ina-1 Integrin Mutants

1997 • 179 citations

Force transmission across muscle cell membranes

1991 • 174 citations

Vinculin is essential for muscle function in the nematode.

1991 • 173 citations

Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila αPS2βPS integrins

1994 • 170 citations

A novel α integrin subunit associates with β PS and functions in tissue morphogenesis and movement during Drosophila development

1997 • 160 citations

Molecular evolution of integrins: Genes encoding integrin β subunits from a coral and a sponge

1997 • 160 citations

cDNA Cloning and Chromosomal Localization of Human α11 Integrin

1999 • 155 citations

kakapo, a Gene Required for Adhesion Between and Within Cell Layers in Drosophila, Encodes a Large Cytoskeletal Linker Protein Related to Plectin and Dystrophin

1998 • 144 citations

Null mutations in the αPS2 and βPS integrin subunit genes have distinct phenotypes

1994 • 133 citations

Type IV Collagen Is Detectable in Most, but Not All, Basement Membranes of Caenorhabditis elegans and Assembles on Tissues That Do Not Express It

1997 • 128 citations

Autosomal Mutations Affecting Adhesion Between Wing Surfaces in Drosophila melanogaster

1997 • 126 citations

Kakapo, a Novel Cytoskeletal-associated Protein Is Essential for the Restricted Localization of the Neuregulin-like Factor, Vein, at the Muscle–Tendon Junction Site

1998 • 124 citations

wing blister, A New Drosophila Laminin α Chain Required for Cell Adhesion and Migration during Embryonic and Imaginal Development

1999 • 123 citations

Myotactin, a Novel Hypodermal Protein Involved in Muscle–Cell Adhesion inCaenorhabditis elegans

1999 • 122 citations

The kakapo Mutation Affects Terminal Arborization and Central Dendritic Sprouting of Drosophila Motorneurons

1998 • 121 citations

The phenogenetics of the embryonic mutant lethal myospheroid, in Drosophila melanogaster

1960 • 119 citations

Singling out Drosophila tendon cells: a dialogue between two distinct cell types

1999 • 119 citations

Absence of PS Integrins or Laminin A Affects Extracellular Adhesion, but Not Intracellular Assembly, of Hemiadherens and Neuromuscular Junctions inDrosophilaEmbryos

1998 • 114 citations

Integrins hold Drosophila together

1993 • 97 citations

A novel, tissue-specific integrin subunit, βν, expressed in the midgut of Drosophila melanogaster

1993 • 96 citations

A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila

1999 • 95 citations

PS2 Integrin Requirements in Drosophila Embryo and Wing Morphogenesis

1993 • 95 citations

Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the αPS1 integrin subunit

1995 • 83 citations

Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2.

1994 • 82 citations

Uncoupling integrin adhesion and signaling: the beta PS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo

1999 • 79 citations

Functions for PS Integrins in Tissue Adhesion, Migration, and Shape Changes during Early Embryonic Development in Drosophila

1995 • 78 citations

Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.

1996 • 77 citations

Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain

1997 • 76 citations

The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila

1998 • 75 citations

A Screen to Identify Drosophila Genes Required for Integrin-Mediated Adhesion

1998 • 74 citations

Genetic Analysis on the Role of Integrin during Axon Guidance inDrosophila

1998 • 69 citations

Distinct spatial and temporal functions for PS integrins during Drosophila wing morphogenesis

1996 • 67 citations

Splice Variants of the Drosophila PS2 Integrins Differentially Interact with RGD-containing Fragments of the Extracellular Proteins Tiggrin, Ten-m, and D-Laminin α2

1998 • 66 citations

Integrins : molecular and biological responses to the extracellular matrix

1994 • 66 citations

Vinculin gene is non‐essential in Drosophila melanogaster

1997 • 65 citations

Drosophila integrins and their ligands

1994 • 64 citations

Location of the integrin complex and extracellular matrix molecules at the chicken myotendinous junction

1989 • 64 citations

Cell Autonomous Expression of Perlecan and Plasticity of Cell Shape in Embryonic Muscle ofCaenorhabditis elegans

1996 • 60 citations

The function of type IV collagen during Drosophila muscle development

1996 • 60 citations

Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functions.

1999 • 56 citations

Genetic Analysis of the Drosophila αPS2 Integrin Subunit Reveals Discrete Adhesive, Morphogenetic and Sarcomeric Functions

1998 • 55 citations

Intracellular signals direct integrin localization to sites of function in embryonic muscles.

1996 • 53 citations

Cloning and characterization of αPS1, a novel Drosophila melanogaster integrin

1993 • 51 citations

Mouse myoblasts can fuse and form a normal sarcomere in the absence of β1 integrin expression

1998 • 50 citations

Molecular Cloning of Macrophin, a Human Homologue of Drosophila Kakapo with a Close Structural Similarity to Plectin and Dystrophin

1999 • 37 citations

Alternatively spliced forms of the Drosophila αPS2 subunit of integrin are sufficient for viability and can replace the function of the αPS1 subunit of integrin in the retina

1996 • 26 citations

Integrins: Molecular and biological responses to the extracellular matrix

1995 • 26 citations

The PS Integrins Are Required for a Regulatory Event during Drosophila Wing Morphogenesis^a

1998 • 9 citations