Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

2003 • 1,967 citations

Diseases of the Breast

1971 • 1,803 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Morphogenesis of the Polarized Epithelial Cell Phenotype

1989 • 1,087 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

2002 • 763 citations

Adaptation of core mechanisms to generate cell polarity

2003 • 696 citations

The organizing principle: microenvironmental influences in the normal and malignant breast

2002 • 603 citations

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

2001 • 559 citations

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

2004 • 528 citations

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

2003 • 524 citations

Genetic variation in DLG5 is associated with inflammatory bowel disease

2004 • 479 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Myc pathways provoking cell suicide and cancer

2003 • 461 citations

Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

2000 • 444 citations

Histological and biological evolution of human premalignant breast disease.

2001 • 424 citations

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

2001 • 408 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

c-Myc in breast cancer.

2000 • 337 citations

Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.

1984 • 336 citations

Parsing the Polarity Code

2004 • 335 citations

C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance

2000 • 295 citations

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

1999 • 295 citations

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

2003 • 294 citations

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

2005 • 259 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

2006 • 234 citations

Role of JNK in Tumor Development

2003 • 229 citations

Scrib Controls Cdc42 Localization and Activity to Promote Cell Polarization during Astrocyte Migration

2006 • 221 citations

Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor

2004 • 212 citations

Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

2005 • 207 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

2006 • 180 citations

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

1997 • 159 citations

Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice.

1995 • 149 citations

Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes

2005 • 142 citations

Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression

2006 • 140 citations

Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble

2004 • 133 citations

A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development

2004 • 131 citations

Defining a role for c-Myc in breast tumorigenesis

1997 • 125 citations

Apicobasal polarity complexes

2005 • 110 citations

Pro-apoptotic Bim Induction in Response to Nerve Growth Factor Deprivation Requires Simultaneous Activation of Three Different Death Signaling Pathways

2007 • 97 citations

Synergistic interaction of transforming growth factor alpha and c-myc in mouse mammary and salivary gland tumorigenesis.

1995 • 89 citations

The PIX–GIT complex: A G protein signaling cassette in control of cell shape

2008 • 87 citations

Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis: coordinated stimulation of growth and suppression of apoptosis.

1996 • 83 citations

Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dβ cell line

2006 • 76 citations

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling

2004 • 62 citations

Biological features of premalignant disease in the human breast.

2000 • 54 citations

Using Three‐Dimensional Acinar Structures for Molecular and Cell Biological Assays

2006 • 47 citations

What is Drosophila telling us about cancer?

1999 • 43 citations

Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells

2003 • 39 citations

Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2.

1997 • 32 citations

Cultured Mouse Mammary Epithelial Cells: Normal Phenotype After Implantation<xref ref-type="fn" rid="FN2">2</xref>

1987 • 29 citations

Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue.

1987 • 27 citations

Junction genetics

1997 • 27 citations

Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice

2004 • 19 citations

Spontaneous conversion to estrogen receptor expression by the human breast epithelial cell line, MCF-10A.

1999 • 17 citations

Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence

2003 • 13 citations

Viral Ha-ras mediated mammary tumor progression.

1991 • 11 citations

Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue.

1987 • 9 citations

Tissue reconstitution, or transgenic mammary gland, technique for modeling breast cancer development

1996 • 7 citations