Radiation-induced bystander effects in vivo are sex specific

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Genomic DNA methylation: the mark and its mediators

2006 • 2,428 citations

PCNA, the Maestro of the Replication Fork

2007 • 1,682 citations

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

2006 • 1,625 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

2003 • 647 citations

Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander EffectsIn Vivo,Clastogenic Factors and Transgenerational Effects

2003 • 535 citations

Ki67 protein: the immaculate deception?

2002 • 495 citations

Radiation-induced bystander effects — implications for cancer

2004 • 462 citations

Genomic patterns of DNA methylation: targets and function of an epigenetic mark

2007 • 377 citations

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

2001 • 371 citations

Factors underlying the cell growth-related bystander responses to alpha particles.

2000 • 346 citations

The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells

2001 • 308 citations

Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away

2005 • 295 citations

DNA Double-Strand Breaks Form in Bystander Cells after Microbeam Irradiation of Three-dimensional Human Tissue Models

2007 • 231 citations

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation

2003 • 229 citations

Non-targeted bystander effects induced by ionizing radiation

2006 • 222 citations

Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo

2006 • 216 citations

Intercellular and Intracellular Signaling Pathways Mediating Ionizing Radiation-Induced Bystander Effects

2007 • 213 citations

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

2005 • 208 citations

DNA adduct 8-hydroxyl-2′-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase

1995 • 207 citations

A Sensitive New Method for Rapid Detection of Abnormal Methylation Patterns in Global DNA and within CpG Islands

1999 • 204 citations

Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes

2004 • 183 citations

Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo

2007 • 180 citations

Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus

2005 • 163 citations

Radiation-induced effects in unirradiated cells: A review and implications in cancer

2002 • 158 citations

Individual variation in the production of a `bystander signal' following irradiation of primary cultures of normal human urothelium

2001 • 144 citations

The time and spatial effects of bystander response in mammalian cells induced by low dose radiation

2005 • 142 citations

Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers

2003 • 141 citations

A Dose Threshold for a Medium Transfer Bystander Effect for a Human Skin Cell Line

2006 • 138 citations

Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation

2004 • 133 citations

Breaks in Normal Human Chromosomes: Are They Induced by a Transferable Substance in the Plasma of Persons Exposed to Total-Body Irradiation?

1968 • 132 citations

Bystander-induced Apoptosis and Premature Differentiation in Primary Urothelial Explants after Charged Particle Microbeam Irradiation

2002 • 125 citations

Untargeted effects of ionizing radiation: Implications for radiation pathology

2006 • 119 citations

Characterization of a novel epigenetic effect of ionizing radiation: the death-inducing effect.

2003 • 119 citations

Bystander and Delayed Effects after Fractionated Radiation Exposure

2002 • 118 citations

Stable loss of global DNA methylation in the radiation-target tissue—A possible mechanism contributing to radiation carcinogenesis?

2005 • 117 citations

Radiation-induced bystander effects, carcinogenesis and models

2003 • 113 citations

In Vivo Bystander Effect: Cranial X-Irradiation Leads to Elevated DNA Damage, Altered Cellular Proliferation and Apoptosis, and Increased p53 Levels in Shielded Spleen

2008 • 110 citations

A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation

2003 • 109 citations

Bystander-induced differentiation: A major response to targeted irradiation of a urothelial explant model

2006 • 103 citations

The Effect of γ Radiation on DNA Methylation

1989 • 102 citations

Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice

2004 • 99 citations

Characterization of a Radiation-Induced Stress Response Communicated in Vivo between Zebrafish

2007 • 98 citations

Bystander effect: Biological endpoints and microarray analysis

2006 • 90 citations

Targeted and Nontargeted Effects of Low-Dose Ionizing Radiation on Delayed Genomic Instability in Human Cells

2007 • 89 citations

Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells

2006 • 88 citations

Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals.

1977 • 88 citations

Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes

2006 • 86 citations

Effects of irradiated medium with or without cells on bystander cell responses

2002 • 81 citations

IR-inducible clusterin gene expression: a protein with potential roles in ionizing radiation-induced adaptive responses, genomic instability, and bystander effects

2004 • 81 citations

Assessment of Low Linear Energy Transfer Radiation–Induced Bystander Mutagenesis in a Three-Dimensional Culture Model

2005 • 80 citations

The Radiation-Induced Bystander Effect for Clonogenic Survival

2002 • 79 citations

Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells

2004 • 78 citations

Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues.

1998 • 77 citations

Bystander effects induced by serum from survivors of the Chernobyl accident

2007 • 76 citations

Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells

2006 • 74 citations

Genetic Factors Influencing Bystander Signaling in Murine Bladder Epithelium after Low-Dose IrradiationIn Vivo

2005 • 74 citations

Modulation of Radiation Responses by Pre-exposure to Irradiated Cell Conditioned Medium

2007 • 71 citations

Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and oligoelements

1997 • 71 citations

Evidence for ‘bystander effects’ in vivo

2004 • 61 citations

Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions

2007 • 57 citations

Genotoxic Damage in Non-irradiated Cells: Contribution from the Bystander Effect

2002 • 57 citations

The incidence of childhood leukaemia around the La Hague nuclear waste reprocessing plant (France): a survey for the years 1978-1998

2001 • 56 citations

Quantification of 3′OH DNA Breaks by Random Oligonucleotide-Primed Synthesis (ROPS) Assay

1996 • 56 citations

A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts

2006 • 46 citations

Intestinal Epithelial Cell Dysfunction is Mediated by an Endothelial-Specific Radiation-Induced Bystander Effect

2007 • 40 citations

Dissimilar genome response to acute and chronic low-dose radiation in male and female mice

2004 • 40 citations

Hyperoxia-Induced DNA Damage Causes Decreased DNA Methylation in Human Lung Epithelial-Like A549 Cells

2004 • 33 citations

Exacerbating factors of radiation-induced myeloid leukemogenesis

1993 • 31 citations

Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo

2005 • 22 citations

Sex and tissue-specific differences in low-dose radiation-induced oncogenic signaling

2005 • 19 citations

Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells.

2003 • 9 citations