Radiation-induced effects in unirradiated cells: A review and implications in cancer

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

1988 • 1,434 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA

1994 • 1,142 citations

Cell Proliferation in Carcinogenesis

1990 • 1,063 citations

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

1992 • 979 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery

2000 • 601 citations

Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells

1997 • 592 citations

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells

2001 • 586 citations

Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles

1998 • 509 citations

Leukemia Following Hodgkin's Disease

1990 • 502 citations

Second malignant neoplasms in children: an update from the Late Effects Study Group.

1985 • 488 citations

Tumor Therapy with Targeted Atomic Nanogenerators

2001 • 483 citations

Induction of a bystander mutagenic effect of alpha particles in mammalian cells

2000 • 473 citations

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

Second Nonocular Tumors in Retinoblastoma Survivors

1984 • 442 citations

Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

1999 • 427 citations

Cell-Cell Contact during Gamma Irradiation Is Not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for Release during Irradiation of a Signal Controlling Survival into the Medium

1998 • 423 citations

Studies of bystander effects in human fibroblasts using a charged particle microbeam

1998 • 410 citations

Ganciclovir

1990 • 399 citations

Lung Cancer in Radon-Exposed Miners and Estimation of Risk From Indoor Exposure

1995 • 378 citations

Initiation of chemical carcinogenesis requires cell proliferation

1978 • 345 citations

DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis.

1993 • 334 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

Sister chromatid exchanges induced in chinese hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through S

1974 • 312 citations

The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells

2001 • 308 citations

Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation

1998 • 303 citations

The Response of Chinese Hamster V79 Cells to Low Radiation Doses: Evidence of Enhanced Sensitivity of the Whole Cell Population

1993 • 293 citations

Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

1996 • 286 citations

Second cancers following pediatric Hodgkin's disease.

1998 • 274 citations

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 • 273 citations

Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect

1999 • 265 citations

Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.

1997 • 264 citations

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

1996 • 263 citations

Relative Contribution of Bystander and Targeted Cell Killing to the Low-Dose Region of the Radiation Dose–Response Curve

2000 • 256 citations

Patterns of second malignant neoplasms in children

1977 • 253 citations

Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability

2001 • 252 citations

Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts

2001 • 222 citations

Spontaneous and Induced Sister Chromatid Exchanges as Revealed by the BUdR-Labeling Method

1977 • 220 citations

Radiation risk to low fluences of α particles may be greater than we thought

2001 • 218 citations

The Bystander Effect in Radiation Oncogenesis: II. A Quantitative Model

2001 • 216 citations

Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation.

2000 • 211 citations

α-particle-induced chromosomal instability in human bone marrow cells

1994 • 200 citations

How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

1998 • 191 citations

Alpha Particles Induce the Production of Interleukin-8 by Human Cells

1999 • 188 citations

Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells

2002 • 182 citations

Description and dosimetric verification of the <scp>PEREGRINE</scp> Monte Carlo dose calculation system for photon beams incident on a water phantom

2001 • 174 citations

Reactive oxygen species and silica‐induced carcinogenesis

1998 • 170 citations

Aspects of the adaptive response to very low doses of radiation and other agents

1996 • 170 citations

TNFα and IL-1β mediate intercellular adhesion molecule-1 induction via microglia–astrocyte interaction in CNS radiation injury

1999 • 159 citations

Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform Distribution of Incorporated Radioactivity in a Three-Dimensional Tissue Culture Model

2001 • 153 citations

Chromosome Damage Induced by Plasma of X-Rayed Patients: An Indirect Effect of X-Ray

1968 • 152 citations

HPRTMutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations

2001 • 133 citations

In vivo analysis of the 'bystander effect': a cytokine cascade.

1996 • 132 citations

Breaks in Normal Human Chromosomes: Are They Induced by a Transferable Substance in the Plasma of Persons Exposed to Total-Body Irradiation?

1968 • 132 citations

Alpha-Particle-Induced Increases in the Radioresistance of Normal Human Bystander Cells

2002 • 132 citations

Evidence for Pronounced Bystander Effects Caused by Nonuniform Distributions of Radioactivity using a Novel Three-Dimensional Tissue Culture Model

1999 • 126 citations

Clastogenic activity from Bloom syndrome fibroblast cultures.

1981 • 114 citations

Changes in sternal marrow following roentgen-ray therapy to the spleen in chronic granulocytic leukemia

1954 • 113 citations

Clastogenic Factors in the Plasma of Chernobyl Accident Recovery Workers: Anticlastogenic Effect of Ginkgo biloba Extract

1995 • 111 citations

On the Reaction Kinetics of the Radioadaptive Response in Cultured Mouse Cells

1995 • 109 citations

Radiation-Induced Pneumonitis in the “Nonirradiated” Lung

1999 • 108 citations

Effects of Ionizing Radiation in Targeted and Nontargeted Cells

2000 • 108 citations

Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor

1994 • 106 citations

Production of Delayed Death and Neoplastic Transformation in CGL1 Cells by Radiation-Induced Bystander Effects

2001 • 103 citations

Non‐ocular cancer in patients with hereditary retinoblastoma and their relatives

1988 • 100 citations

Hydrogen Peroxide and the Proliferation of Bhk-21 Cells

1995 • 92 citations

Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals.

1977 • 88 citations

Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts.

2000 • 83 citations

Bilateral lymphocytic alveolitis: a common reaction after unilateral thoracic irradiation

1999 • 83 citations

Second malignant neoplasms in patients treated for hodgkin's disease with radiotherapy or radiotherapy and chemotherapy

1981 • 82 citations

Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes

2000 • 82 citations

Effects of irradiated medium with or without cells on bystander cell responses

2002 • 81 citations

Antioxidant Regulation of Phorbol Ester-Induced Adhesion of Human Jurkat T-Cells to Endothelial Cells

1998 • 76 citations

Radiation-induced clastogenic plasma factors

1984 • 74 citations

Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation

1996 • 73 citations

A low, adaptive dose of gamma-rays reduced the number and altered the spectrum of S1− mutants in human-hamster hybrid AL cells

1996 • 69 citations

Ionizing Radiation Alters Fas Antigen Ligand at the Cell Surface and on Exfoliated Plasma Membrane-Derived Vesicles: Implications for Apoptosis and Intercellular Signaling

2000 • 69 citations

Aggressive management of second primary tumors in survivors of hereditary retinoblastoma

1989 • 67 citations

Endogenously Generated Active Oxygen Species and Cellular Glutathione Levels in Relation to BHK-21 Cell Proliferation

1994 • 65 citations

A diffusable clastogenic factor in ataxia telangiectasia

1980 • 60 citations

Clastogenic inosine nucleotide as components of the chromosome breakage factor in scleroderma patients

1990 • 57 citations

Small Doses of High-Linear Energy Transfer Radiation Increase the Radioresistance of Chinese Hamster V79 Cells to Subsequent X Irradiation

1996 • 54 citations

Alterations in the Progression of Cells through the Cell Cycle after Exposure to Alpha Particles or Gamma Rays

1996 • 54 citations

A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny.

1997 • 52 citations

THE EFFECT OF IRRADIATED PLASMA ON NORMAL HUMAN CHROMOSOMES AND ITS RELEVANCE TO THE LONG‐LIVED LYMPHOCYTE HYPOTHESIS

1969 • 50 citations

Second malignant neoplasms in children after treatment of soft tissue sarcoma

1997 • 50 citations

The Bystander Effect in C3H 10T Cells and Radon-Induced Lung Cancer

2001 • 48 citations

No Evidence for Chromosomal Instability in Radiation Workers withIn VivoExposure to Plutonium

2001 • 48 citations

Gap Junction Intercellular Communication Mediates the Competitive Cell Proliferation Disadvantage of Irradiated Mouse Preimplantation Embryos in Aggregation Chimeras

1999 • 44 citations

Bystander effects: A concept in need of clarification

2000 • 42 citations

The Potential Impact of Bystander Effects on Radiation Risks in a Mars Mission

2001 • 41 citations

EPA’s Perspective on Risks from Residential Radon Exposure

1989 • 40 citations

Lack of Detectable Transmissible Chromosomal Instability afterIn VivoorIn VitroExposure of Mouse Bone Marrow Cells to²²⁴Ra Alpha Particles

2001 • 40 citations

Tumour Development in the Rat induced by Blood of Irradiated Animals

1962 • 34 citations

Intracellular regulation of the production and release of human erythroid-directed lymphokines.

1991 • 30 citations

Changes in the Rat Lung after Exposure to Radon and Its Progeny: Effects on Incorporation of Bromodeoxyuridine in Epithelial Cells and on the Incidence of Nuclear Aberrations in Alveolar Macrophages

1994 • 29 citations

A new method for the identification of SCE's per cell cycle in BrdUrd ? Substituted chromosomes

1980 • 27 citations

EFFECT OF RADON ON THE IMMUNE SYSTEM: ALTERATIONS IN THE CELLULARITY AND FUNCTIONS OF T CELLS IN LYMPHOID ORGANS OF MOUSE

1996 • 27 citations

Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells

1997 • 27 citations

Ultrastructural Events in the Cytoplasmic Death of Lethally-irradiated Human Lymphocytes

1977 • 24 citations

Cell-Type-Dependent Induction of eotaxin and CCR3 by Ionizing Radiation

2000 • 22 citations

The Microdosimetry of Radon Decay Products in the Respiratory Tract

1990 • 22 citations

Inhibitory effects of vesicles shed by human breast carcinoma cells on lymphocyte 3H-thymidine incorporation, are neutralised by anti TGF-beta antibodies.

1995 • 19 citations

Plasma Membrane as a Sensitive Target in Radiation-induced Cell Injury and Death: An Ultrastructural Study

1981 • 17 citations

Cancer anorexia/cachexia

1999 • 16 citations

Protein Kinase C- and Ca2+ Ionophore-Stimulated Production of Reactive Oxygen Species in Mechanically Dispersed Isolated Bovine Luteal Cells1

1997 • 13 citations

Chromosomal abnormalities in lymphocytes of children and baby rabbits born from mothers treated by X-irradiation before pregnancy. A transplacentary plasmatic chromosome-Damaged factor?

1971 • 13 citations

Model for Assessing Radiation Dose to Epithelial Cells of the Human Respiratory Tract from Radon Progeny

1991 • 11 citations

CHROMOSOME ABERRATIONS INDUCED BY PLASMA FROM IRRADIATED PATIENTS: A BRIEF REPORT.

1967 • 11 citations

Modulation by novobiocin of sister-chromatid exchanges induced by tumor necrosis factor in human lymphocytes

1992 • 10 citations

Increasing radiosensitivity in the course of fractionated X irradiation: the effect of contact with dead and dying cells.

1998 • 10 citations

Effects of radiation on rat respiratory epithelial cells: Critical target cell populations and the importance of cell-cell interactions

1994 • 6 citations

[Migratory pneumonitis similar to bronchiolitis obliterans organizing pneumonia after conservative treatment of breast cancer: a case report].

1999 • 2 citations