Inhibition of γ-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones

Enzyme distribution along the nephron

1984 • 490 citations

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

1986 • 208 citations

A cyclic voltammetric study of the aqueous electrochemistry of some quinones

1985 • 201 citations

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.

1988 • 165 citations

Glutathione conjugates of 2-bromohydroquinone are nephrotoxic.

1985 • 126 citations

Cis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations.

1985 • 110 citations

Enzymes of renal origin in urine as indicators of nephrotoxicity*1

1977 • 98 citations

Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone.

1988 • 81 citations

The activities of the key enzymes of the γ‐glutamyl cycle in microdissected segments of the rat nephron

1977 • 78 citations

Mechanism of renal necrosis induced by bromobenzene

1973 • 72 citations

Formation of toxic metabolites from drugs and other xenobiotics by glutathione conjugation

1988 • 63 citations

2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants.

1988 • 63 citations

The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells

1991 • 60 citations

Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: implications for bromobenzene-induced nephrotoxicity.

1984 • 51 citations

The role of ortho-bromophenol in the nephrotoxicity of bromobenzene in rats

1984 • 48 citations

Disposition and nephrotoxicity of 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (APD), in rats and mice

1990 • 44 citations

Nephrotoxicity of S-(2-chloroethyl)glutathione in the Fischer rat: evidence for gamma-glutamyltranspeptidase-independent uptake by the kidney.

1987 • 40 citations

The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of γ-glutamyl transpeptidase inhibition

1990 • 37 citations

Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione

1990 • 34 citations

Glutathione, γ-glutamyl transpeptidase, and the mercapturic acid pathway as modulators of 2-bromohydroquinone oxidation

1990 • 33 citations

Comparative toxicity of 1,2,3,4‐, 1,2,4,5‐, and 1,2,3,5‐tetrachlorobenzene in the rat: Results of acute and subacute studies

1983 • 30 citations

Oxidative cyclization, 1,4-benzothiazine formation and dimerization of 2-bromo-3-(glutathion-S-yl)hydroquinone.

1990 • 30 citations

Differential uptake of isomeric 2-bromohydroquinone-glutathione conjugates into kidney slices

1988 • 26 citations

Synthesis and nephrotoxicity of 6-bromo-2,5-dihydroxy-thiophenol.

1988 • 18 citations