Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism

Vitamin D Deficiency

2007 • 12,815 citations

Cochrane Database of Systematic Reviews

2008 • 4,700 citations

Vitamin D

1979 • 3,814 citations

Decreased bioavailability of vitamin D in obesity

2000 • 3,081 citations

Vitamin D₃and Calcium to Prevent Hip Fractures in Elderly Women

1992 • 2,963 citations

Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes

2006 • 2,414 citations

Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older

1997 • 2,320 citations

Vitamin D Deficiency and Risk of Cardiovascular Disease

2008 • 2,273 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,778 citations

Klotho converts canonical FGF receptor into a specific receptor for FGF23

2006 • 1,772 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,556 citations

Vitamin effects on the immune system: vitamins A and D take centre stage

2008 • 1,441 citations

Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease

2006 • 1,440 citations

Resurrection of vitamin D deficiency and rickets

2006 • 1,428 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,343 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,286 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis

2007 • 1,216 citations

25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population

2008 • 1,205 citations

Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality

2008 • 1,200 citations

Vitamin D Supplementation and Total Mortality<subtitle>A Meta-analysis of Randomized Controlled Trials</subtitle>

2007 • 1,127 citations

Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004

2009 • 1,122 citations

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

2018 • 1,100 citations

Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy

2008 • 1,098 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,096 citations

Vitamin D

2005 • 1,077 citations

An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3

1999 • 989 citations

Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial

2005 • 977 citations

Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts

2005 • 867 citations

Pharmacokinetics of vitamin D toxicity

2008 • 860 citations

1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.

2001 • 849 citations

Prevalence of Cardiovascular Risk Factors and the Serum Levels of 25-Hydroxyvitamin D in the United States

2007 • 830 citations

Vitamin D levels and early mortality among incident hemodialysis patients

2007 • 783 citations

Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity

2008 • 748 citations

Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis

2009 • 662 citations

Calcium/Vitamin D Supplementation and Cardiovascular Events

2007 • 646 citations

Fibroblast Growth Factor 23 Is a Counter-Regulatory Phosphaturic Hormone for Vitamin D

2006 • 626 citations

Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004

2008 • 625 citations

DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27

2007 • 608 citations

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

1987 • 592 citations

Assay Variation Confounds the Diagnosis of Hypovitaminosis D: A Call for Standardization

2004 • 592 citations

Vitamin D Receptor: New Assignments for an Already Busy Receptor

2006 • 555 citations

1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.

1984 • 493 citations

1,25-Dihydroxyvitamin D3 Suppresses Renin Gene Transcription by Blocking the Activity of the Cyclic AMP Response Element in the Renin Gene Promoter

2007 • 480 citations

Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).

1984 • 471 citations

Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria

1999 • 432 citations

Vitamin D levels and patient outcome in chronic kidney disease

2008 • 428 citations

Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease

2004 • 416 citations

Prevalence of Calcidiol Deficiency in CKD: A Cross-Sectional Study Across Latitudes in the United States

2005 • 396 citations

Vitamin D status and arterial hypertension: a systematic review

2009 • 389 citations

Effects of Dietary Sodium and Hydrochlorothiazide on the Antiproteinuric Efficacy of Losartan

2008 • 351 citations

Which circulating level of 25-hydroxyvitamin D is appropriate?

2004 • 348 citations

Vitamin D in chronic kidney disease: A systemic role for selective vitamin D receptor activation

2005 • 305 citations

Renoprotective role of the vitamin D receptor in diabetic nephropathy

2007 • 296 citations

25-Hydroxyvitamin D Levels and Albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)

2007 • 288 citations

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

2008 • 285 citations

Paricalcitol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy

2006 • 283 citations

25-Hydroxyvitamin D Levels Inversely Associate with Risk for Developing Coronary Artery Calcification

2009 • 271 citations

25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey

2006 • 252 citations

Effect of 1,25(OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats

1998 • 248 citations

Paricalcitol Inhibits Renal Inflammation by Promoting Vitamin D Receptor–Mediated Sequestration of NF-κB Signaling

2008 • 247 citations

Regulation of 25-hydroxyvitamin D3-1α-hydroxylase and production of 1α,25-dihydroxyvitamin D3 by human dendritic cells

2003 • 239 citations

Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3

1996 • 233 citations

1,25-Dihydroxyvitamin D₃decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat

2004 • 221 citations

Long-term bone loss in kidney transplant recipients: a cross-sectional and longitudinal study

1996 • 220 citations

Frequency of Leisure-Time Physical Activity and Serum 25-Hydroxyvitamin D Levels in the US Population: Results from the Third National Health and Nutrition Examination Survey

2008 • 219 citations

Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists

2009 • 208 citations

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury

2009 • 198 citations

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and a Vitamin D Analog Suppresses the Progression of Renal Insufficiency in Uremic Rats

2007 • 196 citations

Hypocalcemia and osteopathy in mice with kidney‐specific megalin gene defect

2002 • 174 citations

1,25-Dihydroxyvitamin D3 targeting of NF-κB suppresses high glucose-induced MCP-1 expression in mesangial cells

2007 • 169 citations

Vitamin D Affects Survival Independently of Vascular Calcification in Chronic Kidney Disease

2009 • 161 citations

Renal Effects of Aliskiren Compared With and in Combination With Irbesartan in Patients With Type 2 Diabetes, Hypertension, and Albuminuria

2009 • 157 citations

Expansion of Antigen-Specific Regulatory T Cells with the Topical Vitamin D Analog Calcipotriol

2009 • 144 citations

Combining an Antiproteinuric Approach with Mycophenolate Mofetil Fully Suppresses Progressive Nephropathy of Experimental Animals

1999 • 140 citations

Serum 25-hydroxyvitamin D status and cardiovascular outcomes in chronic peritoneal dialysis patients: a 3-y prospective cohort study

2008 • 138 citations

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation

2008 • 132 citations

High- versus low-dose ACE inhibition in chronic heart failure

1998 • 129 citations

1α,25-Dihydroxy-vitamin D₃ stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes

2007 • 127 citations

Immunolocalization of calcitriol receptor, 24-hydroxylase cytochrome P-450, and calbindin D28k in human kidney

1994 • 117 citations

Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats

2001 • 116 citations

Defective Photoproduction of Cholecalciferol in Normal and Uremic Humans

1984 • 116 citations

RETRACTED: The anti-inflammatory activity of 1,25-dihydroxyvitamin D3 in macrophages

2006 • 114 citations

Benefits of dietary sodium restriction in the management of chronic kidney disease

2009 • 113 citations

Effects of vitamin D supplementation on the calcium–phosphate balance in renal transplant patients

2008 • 112 citations

25-Hydroxyvitamin D Assays: The Quest For Accuracy

2009 • 112 citations

A genomic perspective on vitamin D signaling.

2009 • 103 citations

Selective use of multiple vitamin D response elements underlies the 1 ,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene

2007 • 103 citations

1,25-dihydroxyvitamin D3 inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression

2005 • 102 citations

Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells

2008 • 95 citations

Vitamin D deficiency and mortality

2009 • 88 citations

Primer on the metabolic bone diseases and disorders of mineral metabolism

2016 • 84 citations

1, 25-Dihydroxyvitamin D₃Modulation of Adipocyte Glucocorticoid Function

2005 • 82 citations

Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy

2006 • 78 citations

Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis

2004 • 71 citations

Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase–Deficient Mice

2009 • 70 citations

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes

2006 • 67 citations

Calcitonin, a Regulator of the 25-Hydroxyvitamin D3 1α-Hydroxylase Gene

2009 • 66 citations

Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats

2009 • 63 citations

1α,25-Dihydroxyvitamin D3 shows strong and additive immunomodulatory effects with cyclosporine A in rat renal allotransplants

2002 • 59 citations

Vitamin D Deficiency and Associated Factors in Hemodialysis Patients

2008 • 57 citations

The role of vitamin D in the prevention of osteoporosis

2005 • 56 citations

Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis

2007 • 56 citations

1,25-Dihydroxyvitamin D<sub>3</sub> Prevents Puromycin Aminonucleoside-Induced Apoptosis of Glomerular Podocytes by Activating the Phosphatidylinositol 3-Kinase/Akt-Signaling Pathway

2009 • 53 citations

Vitamin D Status of Chronic Kidney Disease Patients Living in a Sunny Country

2008 • 53 citations

ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy rats

2006 • 52 citations

Identification of VDR-Responsive Gene Signatures in Breast Cancer Cells

2006 • 51 citations

Relationship between serum 1,25-dihydroxyvitamin D and mortality in patients with pre-dialysis chronic kidney disease

2008 • 48 citations

VDR‐mediated gene expression patterns in resting human coronary artery smooth muscle cells

2006 • 44 citations

Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function

2000 • 43 citations

The Selective Vitamin D Receptor Activator for Albuminuria Lowering (VITAL) Study: Study Design and Baseline Characteristics

2009 • 38 citations

Prevalence of Osteoporosis, Osteopenia, and Vertebral Fractures in Long-Term Renal Transplant Recipients

2007 • 37 citations

VITA-D: Cholecalciferol substitution in vitamin D deficient kidney transplant recipients: A randomized, placebo-controlled study to evaluate the post-transplant outcome

2009 • 33 citations

Specific MAP-Kinase Blockade Protects against Renal Damage in Homozygous TGR(mRen2)27 Rats

2003 • 33 citations

Regulation of 25-hydroxyvitamin D 3 -1-hydroxylase and production of 1,25-dihydroxyvitamin D 3 by human dendritic cells

2017 • 30 citations

Inter‐individual differences in anti‐proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage

2003 • 29 citations

Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor

2009 • 26 citations

Vitamin D Deficiency and Nutritional Rickets in Children

2005 • 25 citations

The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin

2009 • 17 citations