Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Successful immunotherapy of natural killer-resistant established pulmonary melanoma metastases by the intravenous adoptive transfer of syngeneic lymphocytes activated in vitro by interleukin 2.

1984 • 371 citations

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

1992 • 369 citations

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

1992 • 245 citations

"Anomalous" THY-1(+) killer cells in allogeneic and F1-anti-parental mixed leukocyte culture. Relation to natural killer cells and allospecific cytotoxic T lymphocytes

1982 • 237 citations

Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis.

1990 • 222 citations

Leukocyte‐Cell Adhesion: A Molecular Process Fundamental in Leukocyte Physiology

1990 • 208 citations

Decline in mitogen induced proliferation of lymphocytes with increasing age.

1987 • 192 citations

Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood.

1990 • 160 citations

Effects of Aging on Natural Killer Cell Activity and Activation by Interleukin-2 and IFN-α

1994 • 84 citations

IL-7 induces human lymphokine-activated killer cell activity and is regulated by IL-4.

1991 • 82 citations

Induction of human lymphokine-activated killer cells by IFN-alpha and IFN-gamma.

1989 • 70 citations

Expression of integrins and other adhesion molecules on NK cells; Impact of IL‐2 on short‐ and long‐term cultures

1993 • 53 citations

Signal transduction via phosphorylated adhesion molecule, LFA-1β (CD18), is increased by culture of natural killer cells with IL-2 in the generation of lymphokine-activated killer cells

1993 • 37 citations

Antibodies to adhesion molecules inhibit the lytic function of MHC-unrestricted cytotoxic cells by preventing their activation

1992 • 32 citations

Basal Natural Killer Cell Activity of Young versus Elderly Humans

1995 • 24 citations

Natural Killer Cells, Lymphokine-Activated Killer Cells, and Cytolytic T Lymphocytes: Compartmentalization of Age-Related Changes in Cytolytic Lymphocytes?

1994 • 23 citations

A phase II study of combined administration of dacarbazine and carboplatin with home therapy of recombinant interleukin-2 and interferon-?2a in patients with advanced malignant melanoma

1994 • 21 citations

Phenotypic and functional profile of peripheral blood mononuclear cells isolated from melanoma patients undergoing combined immunotherapy and chemotherapy

1993 • 16 citations

Lymphokine-activated killer (LAK) cells: I. Age-dependent decline of LAK cell-mediated cytotoxicity

1987 • 16 citations

Evaluation of lymphokine-activated killer cell development in young and old healthy humans.

1995 • 15 citations

Regulation of natural killer cytotoxicity by recombinant alpha interferons. Augmentation by IFN-alpha 7, an interferon similar to IFN-alpha J.

1989 • 14 citations

Down-regulation of LAK cell-mediated cytotoxicity: cancer and ageing

1990 • 8 citations

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