Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas
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References (59)
Untangling the ErbB signalling network
2001 • 6,623 citations
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
2000 • 2,694 citations
Tumor Antigens Recognized by T Lymphocytes
1994 • 1,238 citations
A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens
1998 • 712 citations
NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
2000 • 690 citations
Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens
1974 • 651 citations
CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4
1997 • 612 citations
Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis
2001 • 589 citations
Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization
1998 • 569 citations
Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization.
1997 • 566 citations
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.
1996 • 561 citations
Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial.
1998 • 530 citations
Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.
1994 • 467 citations
The intriguing role of polymorphonuclear neutrophils in antitumor reactions
2001 • 411 citations
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
1985 • 408 citations
B cells inhibit induction of T cell-dependent tumor immunity
1998 • 393 citations
Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-specific Killer T Cells by Dendritic Cells
2002 • 355 citations
DNA Vaccination Against Rat Her-2/Neu p185 More Effectively Inhibits Carcinogenesis Than Transplantable Carcinomas in Transgenic BALB/c Mice
2000 • 354 citations
Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy
2000 • 349 citations
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes
1991 • 335 citations
Fc receptors are required in passive and active immunity to melanoma
1998 • 322 citations
Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.
1981 • 317 citations
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung
2002 • 309 citations
Perforin Is a Major Contributor to NK Cell Control of Tumor Metastasis
1999 • 290 citations
Immune complex–mediated antigen presentation induces tumor immunity
2002 • 276 citations
Combined Allogeneic Tumor Cell Vaccination and Systemic Interleukin 12 Prevents Mammary Carcinogenesis in HER-2/neu Transgenic Mice
2001 • 236 citations
Humoral immune responses of cancer patients against “Cancer-Testis” antigen NY-ESO-1: Correlation with clinical events
1999 • 230 citations
Immune complex–mediated antigen presentation induces tumor immunity
2002 • 221 citations
Serological analysis of human tumor antigens: molecular definition and implications
1997 • 216 citations
Combination therapy with trastuzumab (Herceptin) and cisplatin for chemoresistant metastatic breast cancer: evidence for receptor-enhanced chemosensitivity.
1999 • 182 citations
A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors
1997 • 178 citations
Cytokines, tumour-cell death and immunogenicity: a question of choice
1997 • 168 citations
Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts.
1997 • 157 citations
The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors.
2001 • 157 citations
Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumor effects in vivo.
1988 • 155 citations
Antibodies against p53 are associated with poor prognosis of colorectal cancer
1995 • 142 citations
An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.
1994 • 130 citations
Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine.
2000 • 116 citations
Prevention of breast tumour development in vivo by downregulation of the p185neureceptor
1995 • 114 citations
Gamma Interferon (IFN-γ) Receptor Null-Mutant Mice Are More Susceptible to Herpes Simplex Virus Type 1 Infection than IFN-γ Ligand Null-Mutant Mice
1999 • 112 citations
DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.
1998 • 107 citations
Preclinical studies with Fc(gamma)R bispecific antibodies and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER-2/neu overexpressing breast cancer.
1997 • 97 citations
Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.
1990 • 91 citations
p185neu protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma
2000 • 84 citations
Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs
1999 • 83 citations
Vaccination with DNA encoding internal proteins of influenza virus does not require CD8+ cytotoxic T lymphocytes: either CD4+ or CD8+ T cells can promote survival and recovery after challenge
2000 • 76 citations
Vaccination with Cytoplasmic ErbB-2 DNA Protects Mice from Mammary Tumor Growth Without Anti-ErbB-2 Antibody
2001 • 70 citations
Helper strategy in tumor immunology: Expansion of helper lymphocytes and utilization of helper lymphokines for experimental and clinical immunotherapy
1988 • 69 citations
CD4+ AND B LYMPHOCYTES IN TRANSPLANTATION IMMUNITY
1993 • 65 citations
Enhanced Humoral Immune Response Correlates With Improved Disease-Free and Overall Survival in American Joint Committee on Cancer Stage II Melanoma Patients Receiving Adjuvant Polyvalent Vaccine
2002 • 60 citations
Vaccination with Her-2/neu DNA or protein subunits protects against growth of a Her-2/neu-expressing murine tumor
2001 • 55 citations
Antitumor vaccines: is it possible to prevent a tumor?
2002 • 48 citations
DNA cancer vaccines: A gene gun approach
1997 • 47 citations
Cancer vaccines, a critical review--Part I.
2002 • 47 citations
IgG2a induced by interleukin (IL) 12-producing tumor cell vaccines but not IgG1 induced by IL-4 vaccine is associated with the eradication of experimental metastases.
1998 • 44 citations
In vitro reeducated T helper cells from sarcoma-bearing mice inhibit sarcoma growth in vivo.
1984 • 39 citations
Synergy between an antibody and CD8+ cells in eliminating an established tumor
1997 • 37 citations
Correlation Between Natural and Antibody-Dependent Cell-Mediated Cytotoxicity Against Tumor Targets in the Mouse. II. Characterization of the Effector Cells
1979 • 36 citations
HER2 peptide-specific CD8+ T cells are proportionally detectable long after multiple DNA vaccinations
2002 • 24 citations