The biological functions of A-kinase anchor proteins1 1Edited by P. E. Wright

Cloned Glutamate Receptors

1994 • 3,989 citations

PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)

2000 • 1,940 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

TRANSCRIPTIONAL REGULATION BY CYCLIC AMP

1997 • 967 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

Pericentrin, a highly conserved centrosome protein involved in microtubule organization

1994 • 579 citations

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

1996 • 557 citations

cAMP-Dependent Regulation of Cardiac L-Type Ca2+ Channels Requires Membrane Targeting of PKA and Phosphorylation of Channel Subunits

1997 • 511 citations

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

1999 • 497 citations

Characterization of Protein Kinase A and Protein Kinase C Phosphorylation of the N-Methyl-D-aspartate Receptor NR1 Subunit Using Phosphorylation Site-specific Antibodies

1997 • 490 citations

Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the Centrosome

1998 • 485 citations

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

2000 • 463 citations

Role of CFTR in Airway Disease

1999 • 441 citations

Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif

1991 • 437 citations

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

1996 • 406 citations

ERM-Merlin and EBP50 Protein Families in Plasma Membrane Organization and Function

2000 • 375 citations

Structural Framework for the Protein Kinase Family

1992 • 333 citations

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

1992 • 327 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Yotiao, a Novel Protein of Neuromuscular Junction and Brain That Interacts with Specific Splice Variants of NMDA Receptor Subunit NR1

1998 • 301 citations

A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP.

1994 • 291 citations

Identification of a Novel Protein Kinase A Anchoring Protein That Binds Both Type I and Type II Regulatory Subunits

1997 • 289 citations

A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events

1998 • 283 citations

Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein

1997 • 254 citations

Protein Kinase A-anchoring Inhibitor Peptides Arrest Mammalian Sperm Motility

1997 • 250 citations

A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2)

1981 • 243 citations

Functional modulation of brain sodium channels by cAMP-dependent phosphorylation

1992 • 239 citations

Characterization of a Novel Giant Scaffolding Protein, CG-NAP, That Anchors Multiple Signaling Enzymes to Centrosome and the Golgi Apparatus

1999 • 239 citations

Cell Cycle Regulation of Cyclin A Gene Expression by the Cyclic AMP-Responsive Transcription Factors CREB and CREM

1995 • 233 citations

A-kinase anchoring proteins: protein kinase A and beyond

2000 • 228 citations

Cytoplasmic Dynein-mediated Assembly of Pericentrin and γ Tubulin onto Centrosomes

2000 • 227 citations

Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate

1998 • 227 citations

D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain

1997 • 220 citations

Compensatory Regulation of RIα Protein Levels in Protein Kinase A Mutant Mice

1997 • 220 citations

Assembly of an A kinase-anchoring protein–β 2 -adrenergic receptor complex facilitates receptor phosphorylation and signaling

2000 • 219 citations

The Major Fibrous Sheath Polypeptide of Mouse Sperm: Structural and Functional Similarities to the A-Kinase Anchoring Proteins

1994 • 215 citations

E3KARP Mediates the Association of Ezrin and Protein Kinase A with the Cystic Fibrosis Transmembrane Conductance Regulator in Airway Cells

2000 • 215 citations

Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

1995 • 212 citations

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

2000 • 208 citations

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

1999 • 208 citations

Direct Interaction of Pericentrin with Cytoplasmic Dynein Light Intermediate Chain Contributes to Mitotic Spindle Organization

1999 • 203 citations

The molecular basis for protein kinase A anchoring revealed by solution NMR.

1999 • 203 citations

Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding

2000 • 199 citations

Regulation, Localization, and Anchoring of Protein Kinase A Subunits during Mouse Sperm Capacitation

1997 • 193 citations

Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450

1999 • 193 citations

Anchoring of protein kinase A facilitates hormone-mediated insulin secretion

1997 • 191 citations

Primary Structure and Function of an A Kinase Anchoring Protein Associated with Calcium Channels

1998 • 186 citations

Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase.

1994 • 185 citations

High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B

1989 • 184 citations

Isolation and characterization of Drosophila cAMP-dependent protein kinase genes.

1988 • 184 citations

Characterization of S-AKAP84, a Novel Developmentally Regulated A Kinase Anchor Protein of Male Germ Cells

1995 • 183 citations

mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes

1999 • 172 citations

Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.

1996 • 169 citations

Selective phosphorylation of the alpha subunit of the sodium channel by cAMP-dependent protein kinase.

1982 • 168 citations

NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum

1999 • 168 citations

Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly

2000 • 163 citations

Isolation and Molecular Characterization of AKAP110, a Novel, Sperm-Specific Protein Kinase A-Anchoring Protein

1999 • 163 citations

Protein Kinase A Associates with Cystic Fibrosis Transmembrane Conductance Regulator via an Interaction with Ezrin

2000 • 161 citations

Dopaminergic Modulation of Sodium Current in Hippocampal Neurons via cAMP-Dependent Phosphorylation of Specific Sites in the Sodium Channel α Subunit

1997 • 159 citations

cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons

2001 • 158 citations

Organelle-specific Targeting of Protein Kinase AII (PKAII)

1997 • 145 citations

Defective Motor Behavior and Neural Gene Expression in RIIβ-Protein Kinase A Mutant Mice

1998 • 144 citations

Signal transduction through the cAMP-dependent protein kinase

1993 • 143 citations

The A-kinase Anchor Protein MAP2B and cAMP-dependent Protein Kinase Are Associated with Class C L-type Calcium Channels in Neurons

1999 • 142 citations

Identification of a 15-kDa cAMP-dependent Protein Kinase-anchoring Protein Associated with Skeletal Muscle L-type Calcium Channels

1997 • 141 citations

The a-Kinase–Anchoring Protein Akap95 Is a Multivalent Protein with a Key Role in Chromatin Condensation at Mitosis

1999 • 140 citations

AKAP350, a Multiply Spliced Protein Kinase A-anchoring Protein Associated with Centrosomes

1999 • 139 citations

AKAP79 and the evolution of the AKAP model

2000 • 137 citations

Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain

2000 • 136 citations

Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca ²⁺ channel activity by cAMP-dependent protein kinase

1997 • 133 citations

Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220

1999 • 133 citations

Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2

1989 • 128 citations

Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase.

1994 • 127 citations

cAMP-dependent Phosphorylation of the Nuclear Encoded 18-kDa (IP) Subunit of Respiratory Complex I and Activation of the Complex in Serum-starved Mouse Fibroblast Cultures

2000 • 124 citations

Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization

2000 • 121 citations

cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta.

1992 • 121 citations

Regulation of the AKAP79-Protein Kinase C Interaction by Ca2+/Calmodulin

1997 • 116 citations

Assembly of AKAP82, a Protein Kinase A Anchor Protein, into the Fibrous Sheath of Mouse Sperm

1997 • 116 citations

Localization of a Novel Human A-Kinase-Anchoring Protein, hAKAP220, during Spermatogenesis

2000 • 115 citations

Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5.

1994 • 114 citations

Cyclic AMP, PKA, and the physiological regulation of adiposity.

1998 • 114 citations

A-kinase Anchoring Protein 100 (AKAP100) is Localized in Multiple Subcellular Compartments in the Adult Rat Heart

1998 • 111 citations

Molecular Characterization of an Anchor Protein (AKAPCE) That Binds the RI Subunit (RCE) of Type I Protein Kinase A from Caenorhabditis elegans

1998 • 106 citations

Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice

1997 • 103 citations

Cloning and Characterization of a Novel A-kinase Anchoring Protein

1996 • 102 citations

Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta.

1992 • 102 citations

Association of Immature Hypophosphorylated Protein Kinase Cε with an Anchoring Protein CG-NAP

2000 • 97 citations

Cloning and Characterization of A-kinase Anchor Protein 100 (AKAP100)

1995 • 97 citations

Alternative Splicing Regulates the Subcellular Localization of a-Kinase Anchoring Protein 18 Isoforms

1999 • 96 citations

Deletion of Type IIα Regulatory Subunit Delocalizes Protein Kinase A in Mouse Sperm without Affecting Motility or Fertilization

1999 • 95 citations

cAMP‐dependent protein kinase and phosphoproteins in mammalian mitochondria. An extension of the cAMP‐mediated intracellular signal transduction

1999 • 95 citations

Phosphorylation at a Single Site in the Rat Brain Sodium Channel Is Necessary and Sufficient for Current Reduction by Protein Kinase A

1997 • 95 citations

Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes

1996 • 94 citations

Identification and differential expression of two forms of regulatory subunits (RII) of cAMP-dependent protein kinase II in Friend erythroleukemic cells. Differentiation and 8-bromo-cAMP elicit a large and selective increase in the rate of biosynthesis of only one type of RII.

1985 • 94 citations

AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region

1998 • 90 citations

Influence of phosphorylation by protein kinase A on CFTR at the cell surface and endoplasmic reticulum

1999 • 89 citations

Molecular Characterization of a cDNA That Encodes Six Isoforms of a Novel Murine A Kinase Anchor Protein

1998 • 86 citations

Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton

1993 • 86 citations

Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction

1999 • 86 citations

AKAP15 Anchors cAMP-dependent Protein Kinase to Brain Sodium Channels

1998 • 82 citations

Mutational Analysis of the A-Kinase Anchoring Protein (AKAP)-binding Site on RII

1996 • 82 citations

Molecular Characterization of AKAP149, a Novel A Kinase Anchor Protein with a KH Domain

1996 • 81 citations

A Kinase–Anchoring Protein (Akap95) Recruits Human Chromosome-Associated Protein (Hcap-D2/Eg7) for Chromosome Condensation in Mitotic Extract

2000 • 79 citations

A Kinase Anchor Protein 75 Targets Regulatory (RII) Subunits of cAMP-dependent Protein Kinase II to the Cortical Actin Cytoskeleton in Non-neuronal Cells

1996 • 79 citations

Single Amino Acids Determine Specificity of Binding of Protein Kinase A Regulatory Subunits by Protein Kinase A Anchoring Proteins

1999 • 78 citations

Serpentine Proteins Slither into the Wingless and Hedgehog Fields

1996 • 74 citations

Follicle-stimulating hormone regulation of A-kinase anchoring proteins in granulosa cells.

1993 • 71 citations

A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus

1997 • 71 citations

Cloning, structure, and expression of the gene for a novel regulatory subunit of cAMP-dependent protein kinase in Caenorhabditis elegans.

1990 • 68 citations

Drosophila cAMP-dependent protein kinase.

1984 • 68 citations

Mutagenesis of the Regulatory Subunit (RIIβ) of cAMP-dependent Protein Kinase IIβ Reveals Hydrophobic Amino Acids That Are Essential for RIIβ Dimerization and/or Anchoring RIIβ to the Cytoskeleton

1995 • 63 citations

Unconventional Myosin VIIA Is a Novel A-kinase-anchoring Protein

2000 • 62 citations

Expression of A Kinase Anchor Protein 121 Is Regulated by Hormones in Thyroid and Testicular Germ Cells

1998 • 61 citations

Molecular Characterization of a Novel A Kinase Anchor Protein from Drosophila melanogaster

1997 • 56 citations

The A kinase anchoring protein is required for mediating the effect of protein kinase A on ROMK1 channels

1998 • 55 citations

Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP‐dependent protein kinase II¹

1999 • 54 citations

Differential expression of isoforms of the regulatory subunit of type II cAMP-dependent protein kinase in rat neurons, astrocytes, and oligodendrocytes.

1987 • 54 citations

Isoform-specific Differences between the Type Iα and IIα Cyclic AMP-dependent Protein Kinase Anchoring Domains Revealed by Solution NMR

2000 • 54 citations

The v-Ki-Ras Oncogene Alters cAMP Nuclear Signaling by Regulating the Location and the Expression of cAMP-dependent Protein Kinase IIβ

1996 • 52 citations

4 Regulation of CFTR Cl− ion channels by phosphorylation and dephosphorylation

1999 • 52 citations

The Differential Response of Protein Kinase A to Cyclic AMP in Discrete Brain Areas Correlates with the Abundance of Regulatory Subunit II

1996 • 47 citations

The Localization and Activity of cAMP-dependent Protein Kinase Affect Cell Cycle Progression in Thyroid Cells

2000 • 42 citations

The Type and the Localization of cAMP-dependent Protein Kinase Regulate Transmission of cAMP Signals to the Nucleus in Cortical and Cerebellar Granule Cells

1999 • 42 citations

Targeting the mouse genome: a compendium of knockouts (part III)

1995 • 41 citations

Localization and functions of Protein Kinase A during Drosophila oogenesis

1995 • 40 citations

Characterization of the Targeting, Binding, and Phosphorylation Site Domains of an A Kinase Anchor Protein and a Myristoylated Alanine-rich C Kinase Substrate-like Analog That Are Encoded by a Single Gene

1999 • 38 citations

Characterization of Structural Features That Mediate the Tethering of Caenorhabditis elegans Protein Kinase A to a Novel A Kinase Anchor Protein

2000 • 37 citations

Membrane Localization of cAMP-dependent Protein Kinase Amplifies cAMP Signaling to the Nucleus in PC12 Cells

1996 • 36 citations

Targeting the mouse genome: a compedium of knockouts

1995 • 31 citations

Molecular motors: Sensing a function for myosin-VIIa

1999 • 31 citations

Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A‐kinase anchoring protein 95^*

2000 • 30 citations

Generation of a Novel A Kinase Anchor Protein and a Myristoylated Alanine-rich C Kinase Substrate-like Analog from a Single Gene

1999 • 27 citations

Regulation of the expression of the regulatory subunit of cAMP-dependent protein kinase II beta in Friend erythroleukemic cells. Evidence for posttranscriptional control and a central role for the C subunit.

1990 • 24 citations

Membrane-bound cAMP-dependent Protein Kinase Controls cAMP-induced Differentiation in PC12 Cells

1999 • 22 citations