The immunologic insult in type 1 diabetes

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES

1974 • 1,463 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens

1988 • 470 citations

DO CD4-POSITIVE CYTOTOXIC T CELLS DAMAGE ISLET β CELLS IN TYPE 1 DIABETES?

1988 • 470 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1977 • 409 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

RELATION BETWEEN BREAST-FEEDING AND INCIDENCE RATES OF INSULIN-DEPENDENT DIABETES MELLITUS

1984 • 344 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1990 • 334 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes

1991 • 297 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Quantitative Estimation of the Pancreatic Islet Tissue in Diabetic Subjects

1955 • 247 citations

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1990 • 245 citations

Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus

1987 • 243 citations

Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages.

1990 • 237 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

1989 • 216 citations

Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

1991 • 212 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

EVIDENCE FOR A FOOD ADDITIVE AS A CAUSE OF KETOSIS-PRONE DIABETES

1981 • 207 citations

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

1990 • 204 citations

The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreas.

1988 • 202 citations

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

1982 • 193 citations

Reduced risk of IDDM among breast-fed children. The Colorado IDDM Registry

1988 • 188 citations

T-Lymphocyte Clone Specific for Pancreatic Islet Antigen

1988 • 188 citations

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1991 • 171 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Identification and Cloning of a Granule Autoantigen (Carboxypeptidase-H) Associated with Type I Diabetes*

1991 • 160 citations

Immunogenetic and Biological Aspects of in Vitro Lymphocyte Allotransformation (MLR) in the Mouse

1973 • 159 citations

Dietary prevention of diabetes in the non-obese diabetic mouse

1988 • 156 citations

A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes Mellitus

1991 • 156 citations

Nasopharyngeal Carcinoma (NPC)

1972 • 156 citations

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

1991 • 147 citations

Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic.

1986 • 145 citations

Mechanisms of pancreatic beta-cell destruction in type I diabetes.

1988 • 145 citations

Interleukin 1 is Potent Modulator of Insulin Secretion from Isolated Rat Islets of Langerhans

1987 • 145 citations

Association between HLA‐DR2 and Production of Tumour Necrosis Factor α and Interleukin 1 by Mononuclear Cells Activated by Lipopolysaccharide

1988 • 144 citations

Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts.

1990 • 135 citations

Heterogeneity in Lymphokine Profiles of CD4⁺ and CD8⁺ T Cells and Clones Activated in vivo and in vitro

1991 • 132 citations

T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.

1991 • 130 citations

Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells

1984 • 130 citations

Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression

1991 • 130 citations

Evidence for IL-6 production by and effects on the pancreatic beta-cell.

1989 • 121 citations

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

1991 • 110 citations

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.

1991 • 108 citations

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

1991 • 107 citations

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes.

1991 • 105 citations

Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis.

1991 • 101 citations

The bimodal effect of interleukin 1 on rat pancreatic beta-cells – stimulation followed by inhibition – depends upon dose, duration of exposure, and ambient glucose concentration

1988 • 101 citations

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited

1992 • 97 citations

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse.

1988 • 94 citations

A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

1989 • 94 citations

Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection.

1989 • 92 citations

Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.

1990 • 84 citations

Mechanisms of Nicotinamide and Thymidine Protection From Alloxan and Streptozocin Toxicity

1988 • 83 citations

Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor

1988 • 78 citations

The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males

1990 • 76 citations

Interferon-γ Enhances the Expression of the Major Histocompatibility Class I Antigens on Mouse Pancreatic Beta Cells

1985 • 75 citations

Involvement of O₂radicals in ‘autoimmune’ diabetes

1989 • 74 citations

Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-? antibody

1991 • 73 citations

Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages

1988 • 72 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma.

1989 • 71 citations

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes.

1992 • 67 citations

Regulation of MHC Protein Expression in Pancreatic β-Cells by Interferon-γ and Tumor Necrosis Factor-α

1988 • 67 citations

Progression From Insulitis to β-Cell Destruction in NOD Mouse Requires L3T4+ T-Lymphocytes

1988 • 63 citations

Insulin‐secreting β‐cells possess specific receptors for interleukin‐1β

1990 • 62 citations

Prevention of Diabetes in NOD Mice by Injection of Autoreactive T-Lymphocytes

1989 • 60 citations

Prevention of Cyclophosphamide-Induced Diabetes by Anti-Vβ8 T-Lymphocyte–Receptor Monoclonal Antibody Therapy in NOD/Wehi Mice

1989 • 57 citations

Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus

1990 • 54 citations

Reactivity to Human Islets and Fetal Pig Proislets by Peripheral Blood Mononuclear Cells From Subjects With Preclinical and Clinical Insulin-Dependent Diabetes

1991 • 53 citations

MHC Molecules and β-Cell Destruction: Immune and Nonimmune Mechanisms

1989 • 52 citations

Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta-cell specific

1991 • 52 citations

Role of macrophages in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice

1990 • 51 citations

Studies on the thymus in nonobese diabetic mouse. I. Changes in the microenvironmental compartments.

1991 • 51 citations

Islet‐infiltrating T cell clones from non‐obese diabetic mice that promote or prevent accelerated onset diabetes

1991 • 49 citations

Perspectives on the Role of Viruses in Insulin-dependent Diabetes

1985 • 49 citations

Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat.

1989 • 45 citations

High and Low Diabetes Incidence Nonobese Diabetic (NOD) Mice: Origins and Characterisation

1991 • 44 citations

Reovirus Infection Enhances Expression of Class I MHC Proteins on Human β-Cell and Rat RINm5F cell

1988 • 42 citations

Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse

1991 • 40 citations

Distinct pathways of CD4 and CD8 cells induce rapid target DNA fragmentation.

1991 • 39 citations

Coffee consumption as trigger for insulin dependent diabetes mellitus in childhood.

1990 • 38 citations

T-cell receptor genes and insulin-dependent diabetes mellitus (IDDM): no evidence for linkage from affected sib pairs.

1990 • 38 citations

Molecular pathology of type 1 diabetes.

1990 • 38 citations

Genetic dissection of T cell receptor V beta gene requirements for spontaneous murine diabetes.

1991 • 37 citations

Interferon-gamma and the sexual dimorphism of autoimmunity.

1990 • 36 citations

Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.

1990 • 36 citations

Prevention of Recurrent Autoimmune Diabetes in BB Rats by Anti-Asialo-GM1 Antibody

1988 • 33 citations

Abnormalities within CD4 and CD8 T lymphocyte subsets in type 1 (insulin-dependent) diabetes

1991 • 32 citations

Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice

1990 • 32 citations

Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage

1991 • 31 citations

Studies on Autoimmunity For Initiation of β-Cell Destruction: V. Decrease of Macrophage-Dependent T Lymphocytes and Natural Killer Cytotoxicity in Silica-Treated BB Rats

1990 • 30 citations

Interleukin‐1 induces rapid and transient expression of the c‐fos proto‐oncogene in isolated pancreatic islets and in purified β‐cells

1990 • 24 citations

Effects of radical scavengers on the development of experimental diabetes.

1990 • 24 citations

Defective inducer T-cell function before the onset of insulin-dependent diabetes mellitus

1991 • 21 citations

T-Lymphocyte Lines Specific for Glutamic Acid Decarboxylase (GAD) the 64K β-Cell Antigen of IDDM

1992 • 20 citations

The Effect of HLA and Insulin‐Dependent Diabetes Mellitus on the Secretion Levels of Tumour Necrosis Factors Alpha and Beta and Gamma Interferon

1990 • 17 citations

Initial role of macrophage in the development of anti-β-cell cellular autoimmunity in multiple low-dose streptozotocin-induced diabetes in mice

1990 • 15 citations

Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat.

1990 • 9 citations

Lack of association of T cell receptor beta-chain constant region polymorphism with insulin-dependent diabetes mellitus in Finland

1990 • 7 citations

Major Histocompatibility Complex Molecules and the Beta Cell: Inferences from Transgenic Models

1990 • 6 citations

Cytokine-mediated beta-cell destruction—the molecular effector mechanism causing IDDM?

1990 • 5 citations

8 T cell defined HLA epitopes and T cell receptor polymorphism in insulin dependent diabetes mellitus

1991 • 4 citations

Interaction of immunoglobulin allotypes (Gm and Km), HLA, and sex in insulin-dependent (type 1) diabetes.

1991 • 3 citations

Studies of concanavalin A in nonobese diabetic mice. II. Lymphocyte tracking and phenotype responses.

1991 • 3 citations

Abnormalities of CD4+ T lymphocyte proliferative responses from patients with recently diagnosed insulin-dependent diabetes mellitus

1990 • 2 citations

Interaction of immunoglobulin allotypes (Gm and Km), HLA, and sex in insulin-dependent (type 1) diabetes.

1991 • 2 citations