Major Histocompatibility Complex Molecules and the Beta Cell: Inferences from Transgenic Models

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY

1983 • 1,275 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

EVIDENCE FOR A LONG PREDIABETIC PERIOD IN TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS

1981 • 480 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom

1986 • 453 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

The pancreatic islets in diabetes

1981 • 349 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1985 • 322 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Antigen presenting function of class II MHC expressing pancreatic beta cells

1988 • 255 citations

The Role of the LFA‐1/ICAM‐1 Interaction in Human Leukocyte Homing and Adhesion

1989 • 254 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus

1987 • 243 citations

Viral particles induce Ia antigen expression on astrocytes

1986 • 241 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

First-Degree Relatives of Patients with Type I Diabetes Mellitus

1985 • 226 citations

METABOLIC AND IMMUNOLOGICAL EFFECTS OF CYCLOSPORIN IN RECENTLY DIAGNOSED TYPE 1 DIABETES MELLITUS

1985 • 177 citations

Germline and somatic mosaicism in transgenic mice

1986 • 175 citations

The non-obese diabetic (NOD) mouse.

1987 • 172 citations

Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells.

1986 • 156 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

Increase in Remission Rate in Newly Diagnosed Type I Diabetic Subjects Treated with Azathioprine

1985 • 138 citations

Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice

1986 • 123 citations

Evidence for IL-6 production by and effects on the pancreatic beta-cell.

1989 • 121 citations

Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas.

1986 • 105 citations

Type I (insulin dependent) diabetes: a disease of slow clinical onset?

1987 • 103 citations

Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection.

1989 • 92 citations

Interferon-γ Enhances the Expression of the Major Histocompatibility Class I Antigens on Mouse Pancreatic Beta Cells

1985 • 75 citations

Regulation of MHC Protein Expression in Pancreatic β-Cells by Interferon-γ and Tumor Necrosis Factor-α

1988 • 67 citations

Expression of major histocompatibility antigens on pancreatic islet cells.

1981 • 60 citations

REOVIRUS INDUCTION OF MHC CLASS II ANTIGEN IN RAT THYROID CELLS

1989 • 54 citations

MHC Molecules and β-Cell Destruction: Immune and Nonimmune Mechanisms

1989 • 52 citations

Compound Receptors in the Cell Membrane: Ruminations from the Borderland of Immunology and Physiology

1984 • 50 citations

A Role for Macrophages in the Pathogenesis of Type 1 Diabetes

1989 • 46 citations

Increase in remission rate in newly diagnosed type I diabetic subjects treated with azathioprine

1985 • 45 citations

Beta 2-microglobulin induces intracellular transport of human class I transplantation antigen heavy chains in Xenopus laevis oocytes.

1984 • 43 citations

Intolerable secretion in tolerant transgenic mice

1988 • 42 citations

Reovirus Infection Enhances Expression of Class I MHC Proteins on Human β-Cell and Rat RINm5F cell

1988 • 42 citations

Speculations on Etiology of Diabetes Mellitus: Tumbler Hypothesis

1988 • 39 citations

Molecular pathology of type 1 diabetes.

1990 • 38 citations

Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.

1989 • 35 citations

Immunotherapy in Type 1 Diabetes

1988 • 32 citations

Immunotherapy Of Type 1 Diabetes

1989 • 28 citations

Clinical forms and natural history of the diabetic syndrome and insulin and glucagon secretion in the BB rat

1983 • 23 citations

Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells

1985 • 18 citations

Islet-cell and insulin autoantibodies in diabetes

1987 • 17 citations

Speculations on etiology of diabetes mellitus. Tumbler hypothesis

1988 • 17 citations

MHC molecules and beta-cell destruction. Immune and nonimmune mechanisms

1989 • 16 citations

Reovirus infection enhances expression of class I MHC proteins on human beta-cell and rat RINm5F cell

1988 • 15 citations