Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-? antibody

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

MONOCLONAL ANTIBODIES TO MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS

1982 • 471 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Genes of the Major Histocompatibility Complex of the Mouse

1983 • 445 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus

1987 • 243 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Role of the Major Histocompatibility Complex Class I Antigens in Tumor Growth and Metastasis

1988 • 201 citations

Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in nod mice

1988 • 199 citations

Administration of Silica Particles or Anti-Lyt2 Antibody Prevents β-Cell Destruction in NOD Mice Given Cyclophosphamide

1988 • 156 citations

Regulation of Gene Expression by Interferons: Control of H-2 Promoter Responses

1988 • 136 citations

Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression

1991 • 130 citations

Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus

1989 • 122 citations

Postinduction Turnoff of Beta-Interferon Gene Expression

1990 • 96 citations

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse.

1988 • 94 citations

Interferon-γ Enhances the Expression of the Major Histocompatibility Class I Antigens on Mouse Pancreatic Beta Cells

1985 • 75 citations

Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese diabetic mice.

1989 • 73 citations

Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma.

1989 • 71 citations

Regulation of MHC Protein Expression in Pancreatic β-Cells by Interferon-γ and Tumor Necrosis Factor-α

1988 • 67 citations

Progression From Insulitis to β-Cell Destruction in NOD Mouse Requires L3T4+ T-Lymphocytes

1988 • 63 citations

Postinduction turnoff of beta-interferon gene expression.

1990 • 61 citations

Association of β-Cell–Specific Expression of Endogenous Retrovirus With Development of Insulitis and Diabetes in NOD Mouse

1988 • 60 citations

Identification of sequences responsible for positive and negative regulation by E1A in the promoter of H-2Kbm1 class I MHC gene.

1990 • 52 citations

Comparison of High— and Low—Diabetes-Incidence NOD Mouse Strains

1989 • 47 citations

Reovirus Infection Enhances Expression of Class I MHC Proteins on Human β-Cell and Rat RINm5F cell

1988 • 42 citations

HLA class I genes integrated into murine cells are inducible by interferon

1983 • 41 citations

Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse

1991 • 40 citations

IDDM in BB Rats: Enhanced MHC Class I Heavy-Chain Gene Expression in Pancreatic Islets

1988 • 37 citations

IDDM in BB rats. Enhanced MHC class I heavy-chain gene expression in pancreatic islets

1988 • 35 citations

Interferon-γ Induces Transcription and Differential Expression of MHC Genes in Rat Insulinoma Cell Line RINm5F

1989 • 7 citations