Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 • 6,302 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

2001 • 1,310 citations

Bafilomycin A1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E Cells.

1998 • 1,245 citations

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

2000 • 1,125 citations

Programmed cell death

1974 • 966 citations

A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

2001 • 947 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

The Phosphatidylinositol 3‐Kinase Inhibitors Wortmannin and LY294002 Inhibit Autophagy in Isolated Rat Hepatocytes

1997 • 828 citations

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1997 • 777 citations

Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

1999 • 762 citations

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 • 754 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Temozolomide and treatment of malignant glioma.

2000 • 695 citations

The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

2001 • 561 citations

Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

2003 • 546 citations

A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation

2001 • 511 citations

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

1996 • 508 citations

Vacuolar Import of Proteins and Organelles From The Cytoplasm

1999 • 459 citations

NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA

1994 • 417 citations

Autophagy and other vacuolar protein degradation mechanisms

1992 • 408 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine

2003 • 375 citations

Autophagy: a barrier or an adaptive response to cancer

2003 • 364 citations

Autophagy, Cytoplasm-to-Vacuole Targeting Pathway, and Pexophagy in Yeast and Mammalian Cells

2000 • 359 citations

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

2001 • 343 citations

Temozolomide, a Novel Alkylating Agent with Activity in the Central Nervous System, May Improve the Treatment of Advanced Metastatic Melanoma

2000 • 315 citations

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

2000 • 311 citations

Programmed Cell Death (PCD): Apoptosis, Autophagic PCD, or Others?

2000 • 307 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Defective Acidification in Human Breast Tumor Cells and Implications for Chemotherapy

1998 • 265 citations

Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma

1997 • 221 citations

Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent

1984 • 212 citations

New Treatment Strategies for Malignant Gliomas

1999 • 180 citations

Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of cyclin-dependent kinase inhibitors, and autophagy

2003 • 162 citations

SKD1 AAA ATPase-Dependent Endosomal Transport is Involved in Autolysosome Formation.

2002 • 136 citations

Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.

2001 • 130 citations

A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter

2000 • 113 citations

Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.

1995 • 98 citations

Inhibitors of vacuolar‐type H⁺‐ATPase suppresses proliferation of cultured cells

1993 • 74 citations

Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: Studies with blasts of leukaemic patients

1995 • 53 citations

Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53

2000 • 50 citations