Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Telomerase activity in human germline and embryonic tissues and cells

1996 • 1,345 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1997 • 946 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

The Telomerase Catalytic Subunit Is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes

1999 • 574 citations

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1999 • 545 citations

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

1999 • 473 citations

Regulated expression of telomerase activity in human T lymphocyte development and activation.

1996 • 416 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1996 • 390 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer.

1998 • 346 citations

Inhibition of human telomerase activity by peptide nucleic acids

1996 • 342 citations

Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation

2000 • 309 citations

Apoptosis, cancer and cancer therapy

1997 • 286 citations

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

2000 • 259 citations

Telomerase activity in human brain tumours

1995 • 217 citations

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA

1998 • 188 citations

Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.

2000 • 187 citations

Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

1998 • 171 citations

Expression profile of the putative catalytic subunit of the telomerase gene.

1998 • 152 citations

Generation of Constitutively Active Recombinant Caspases-3 and -6 by Rearrangement of Their Subunits

1998 • 148 citations

A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter

2000 • 113 citations

Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway.

2000 • 112 citations

Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.

1995 • 98 citations

Differential Telomerase Expression in Human Primary Intracranial Tumors

1997 • 71 citations

Telomerase Activity in Human Gliomas

1998 • 64 citations

Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker

2000 • 52 citations

Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53

2000 • 50 citations

Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter.

2001 • 45 citations

Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector – potential glioblastoma targeting

1998 • 41 citations

The Epidemiology of Central Nervous System Tumors

1983 • 39 citations

Telomerase: A Target for Anticancer Therapy

1999 • 36 citations

Retroviral transfer of CPP32beta gene into malignant gliomas in vitro and in vivo.

1998 • 26 citations

Telomerase activity in human brain tumors

1997 • 23 citations

The CDK inhibitor, p27Kip1, is required for IL-4 regulation of astrocyte proliferation.

1997 • 23 citations