Temozolomide, a Novel Alkylating Agent with Activity in the Central Nervous System, May Improve the Treatment of Advanced Metastatic Melanoma

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1991 • 8,402 citations

High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993

1999 • 1,967 citations

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1997 • 777 citations

Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

1999 • 762 citations

Phase III Multicenter Randomized Trial of the Dartmouth Regimen Versus Dacarbazine in Patients With Metastatic Melanoma

1999 • 756 citations

Cancer principles and practice of oncology

1997 • 659 citations

Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

1992 • 483 citations

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

1998 • 413 citations

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma

1999 • 353 citations

Prospective Randomized Trial of the Treatment of Patients With Metastatic Melanoma Using Chemotherapy With Cisplatin, Dacarbazine, and Tamoxifen Alone or in Combination With Interleukin-2 and Interferon Alfa-2b

1999 • 318 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Phase I trial of temozolomide using an extended continuous oral schedule.

1998 • 284 citations

Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours

1993 • 276 citations

Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma

1997 • 221 citations

Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent

1984 • 212 citations

Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group.

1997 • 197 citations

Treatment of metastatic melanoma with combined chemotherapy containing cisplatin, vinblastine and dacarbazine (CVD) and biotherapy using interleukin-2 and interferon-α

1996 • 176 citations

Intravenous carboplatin for recurrent malignant glioma: a phase II study.

1991 • 173 citations

The charing cross hospital experience with temozolomide in patients with gliomas

1996 • 157 citations

Sequential chemoimmunotherapy with cisplatin, interleukin-2, and interferon alfa-2a for metastatic melanoma.

1993 • 147 citations

Phase I study of temozolomide in paediatric patients with advanced cancer

1998 • 135 citations

Phase II study of prolonged oral therapy with etoposide (VP16) for patients with recurrent malignant glioma

1996 • 115 citations

Treatment of recurrent high grade astrocytoma; results of a systematic review of 1,415 patients.

1998 • 114 citations

Combination of Chemotherapy With Interleukin-2 and Interferon Alfa for the Treatment of Metastatic Melanoma

1999 • 102 citations

Carboplatin and etoposide chemotherapy regimen for recurrent malignant glioma: a phase II study.

1992 • 97 citations

O6-Methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

1998 • 88 citations

Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide

1994 • 87 citations

A Phase I and pharmacokinetic study of temozolomide and cisplatin in patients with advanced solid malignancies.

1999 • 68 citations

Neck Dissection: Past, Present, Future

2005 • 42 citations

Phase II evaluation of infusional etoposide and cisplatin in patients with recurrent astrocytoma.

1990 • 31 citations

Effect of food on the oral bioavailability of temozolomide, a new chemotherapeutic agent.

1996 • 6 citations