A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene Promoter

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Structure and function of telomeres

1991 • 3,524 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1997 • 946 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

1996 • 708 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

A Mammalian Telomerase-Associated Protein

1997 • 656 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

1998 • 614 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

2002 • 475 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Telomerase activity in human cancer

1996 • 399 citations

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

1999 • 392 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family

1997 • 379 citations

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.

1996 • 318 citations

Apoptosis, cancer and cancer therapy

1997 • 286 citations

Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

2001 • 270 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.

1995 • 227 citations

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA

1998 • 188 citations

Clinical implications of telomerase in cancer

1997 • 186 citations

Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck.

1995 • 180 citations

Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?

2002 • 169 citations

Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer.

1999 • 111 citations

ERICE, a Novel FLICE-activatable Caspase

1998 • 109 citations

TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW)

1995 • 106 citations

Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.

1995 • 98 citations

Current molecular aspects of the carcinogenesis of the uterine endometrium

2001 • 92 citations

WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis.

1996 • 88 citations

Implications of apoptotic cell death regulation in cancer therapy

1995 • 69 citations

The significance of human telomerase reverse transcriptase (hTERT) in cancer

2001 • 68 citations

Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.

1991 • 66 citations

Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy

1998 • 63 citations

Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells.

1996 • 61 citations

FADD Gene Therapy for Malignant GliomasIn VitroandIn Vivo

1998 • 53 citations

Telomerase and cancer: time to move from a promising target to a clinical reality

2001 • 47 citations

Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53.

1996 • 42 citations

Transcriptional Targeting for Ovarian Cancer Gene Therapy

2001 • 31 citations

Retroviral transfer of CPP32beta gene into malignant gliomas in vitro and in vivo.

1998 • 26 citations

Modification of Tumor Suppressor Gene Expression in Non-Small Cell Lung Cancer (NSCLC) with a Retroviral Vector Expressing Wildtype (normal) p53. University of Texas M.D. Anderson Cancer Center, Houston, Texas

1996 • 21 citations

Inability to induce the alteration of tumorigenicity and chemosensitivity of p53-null human pancreatic carcinoma cells after the transduction of wild-type p53 gene.

1997 • 21 citations

Telomerase and oral cancer

2001 • 15 citations

Telomerase in human tumors: molecular diagnosis andclinical significance

2001 • 5 citations