NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA

A new force field for molecular mechanical simulation of nucleic acids and proteins

1984 • 4,553 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

1992 • 483 citations

Molecular electrostatic potential of the nucleic acids

1981 • 408 citations

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours

1993 • 276 citations

DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

1987 • 233 citations

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

1993 • 195 citations

O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary.

1991 • 115 citations

Dealkylation and Debenzylation of Triesters of Phosphoric Acid. Phosphorylation of Hydroxy and Amino Compounds

1955 • 108 citations

New Avenues in Developmental Cancer Chemotherapy

1987 • 93 citations

Comparison of the cytotoxicity in vitro of temozolomide and dacarbazine, prodrugs of 3-methyl-(triazen-1-yl)imidazole-4-carboxamide

1991 • 90 citations

In vivo metabolism and reaction with dna of the cytostatic agent, 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC)

1986 • 88 citations

DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one.

1984 • 67 citations

Antitumor imidazotetrazines. 14. Synthesis and antitumor activity of 6- and 8-substituted imidazo[5,1-d]-1,2,3,5-tetrazinones and 8-substituted pyrazolo[5,1-d]-1,2,3,5-tetrazinones

1987 • 66 citations

In vivo measurement of regional brain tissue pH using positron emission tomography

1984 • 57 citations

Antitumor imidazotetrazines. 25. Crystal structure of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) and structural comparisons with the related drugs mitozolomide and DTIC

1992 • 55 citations

Steric accessibility of reactive centers in B‐DNA

1981 • 55 citations

Imidazoles. II. 5(or 4)-(Monosubstituted Triazeno)imidazole-4(or 5)-carboxamides¹

1966 • 45 citations

Antitumor imidazotetrazines. 20. Preparation of the 8-acid derivative of mitozolomide and its utility in the preparation of active antitumor agents

1990 • 42 citations

DNA sequence specificity of guanine N⁷-alkylations for a series of structurally related triazenes

1988 • 23 citations

Anti-tumour imidazotetrazines. Part XXI. Mitozolomide and temozolomide: probes for the major groove of DNA.

1990 • 21 citations

Decomposition of 1,3-dialkyltriazenes in aqueous buffers: kinetic and mechanistic studies

1986 • 21 citations

Charge calculations in molecular mechanics 6: the calculation of partial atomic charges in nucleic acid bases and the electrostatic contribution to DNA base pairing

1988 • 18 citations

The mechanism of decomposition of N-methyl-N-nitrosourea in aqueous solution according to¹³C and¹⁵N NMR studies: quantitative fragmentation to cyanate

1991 • 10 citations

The methyldiazonium ion in water: competition between hydrolysis and proton exchange

1985 • 9 citations