Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

1997 • 718 citations

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1998 • 628 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

RELATIONSHIPS BETWEEN DNA REPAIR AND TRANSCRIPTION

1996 • 235 citations

Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.

1995 • 193 citations

Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

1990 • 187 citations

Loss of heterozygosity induced by a chromosomal double-strand break

1997 • 183 citations

Chromosomal Double-Strand Breaks Induce Gene Conversion at High Frequency in Mammalian Cells

1997 • 173 citations

Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines

1998 • 168 citations

In CHEF Electrophoresis a Linear Induction of Dsb Corresponds to a Nonlinear Fraction of Extracted DNA with Dose

1990 • 139 citations

Unequal homologous recombination between LINE-1 elements as a mutational mechanism in human genetic disease 1 1Edited by J. Karn

1998 • 136 citations

Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts.

1993 • 135 citations

Transcription enhances intrachromosomal homologous recombination in mammalian cells.

1992 • 132 citations

Specific Mismatch Recognition in Heteroduplex Intermediates by p53 Suggests a Role in Fidelity Control of Homologous Recombination

1998 • 132 citations

Transcription by RNA polymerase I stimulates mitotic recombination in Saccharomyces cerevisiae.

1989 • 125 citations

Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells

1996 • 118 citations

Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome.

1994 • 117 citations

Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome

1998 • 116 citations

Isolation of polymorphic DNA fragments from human chromosome 4

1987 • 100 citations

Differences between rodent and human cell lines in the amount of integrated DNA after transfection*1

1987 • 92 citations

DNA Double-strand Break Induction and Rejoining as Determinants of Human Tumour Cell Radiosensitivity. A Pulsed-field Gel Electrophoresis Study

1995 • 84 citations

Wortmannin Inhibits Repair of DNA Double-Strand Breaks in Irradiated Normal Human Cells

1998 • 74 citations

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair

1996 • 72 citations

Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts

2000 • 67 citations

Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

1998 • 64 citations

Distribution of radiation-induced G1 exchange and terminal deletion breakpoints in Chinese hamster chromosomes as detected by G banding.

1994 • 62 citations

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT

1997 • 60 citations

Illegitimate Recombination Leading to Allelic Loss and Unbalanced Translocation in p53-Mutated Human Lymphoblastoid Cells

1997 • 57 citations

Mechanisms of Nonhomologous DNA End-Joining in Frogs, Mice and Men

1996 • 56 citations

DNA Double-Strand Breaks Induced by High-Energy Neon and Iron Ions in Human Fibroblasts. II. Probing Individual NotI Fragments by Hybridization

1994 • 51 citations

Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends

1997 • 41 citations

DNA Double-strand Break Measurement in Mammalian Cells by Pulsed-field Gel Electrophoresis: An Approach Using Restriction Enzymes and Gene Probing

1994 • 41 citations

Isolation of polymorphic DNA segments from human chromosome 21

1985 • 38 citations

Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones.

1992 • 37 citations

Links between chromatin structure, DNA repair and chromosome fragility

1998 • 36 citations

Reparable and Non-reparable DNA Strand Breaks Induced by X-irradiation in CHO K1 Cells and the Radiosensitive Mutantsxrs1andxrs5

1993 • 36 citations

Frequent deletions in nine newly immortal human cell lines

1992 • 34 citations

Characterization of homologous DNA recombination activity in normal and immortal mammalian cells

1996 • 33 citations

Two methods for assaying DNA double-strand break repair in mammalian cells by asymmetric field inversion gel electrophoresis.

1993 • 27 citations

Random-breakage mapping, a rapid method for physically locating an internal sequence with respect to the ends of a DNA molecule

1990 • 20 citations

Carcinogens stimulate intrachromosomal homologous recombination at an endogenous locus in human diploid fibroblasts

1997 • 20 citations

Two Methods for Assaying DNA Double-Strand Break Repair in Mammalian Cells by Asymmetric Field Inversion Gel Electrophoresis

1993 • 18 citations

Physical mapping of the human hprt chromosomal region (Xq26)

1995 • 17 citations

A Comparison of Radiation-Induced Aberrations in Human Cells Involving Early and Late Replicating X-Chromosomes

1994 • 11 citations

Large deletions partially external to the human hyrt gene result in chimeric transcripts

1997 • 7 citations

Random-breakage mapping method applied to human DNA sequences

1996 • 5 citations

Study of Alu sequences at the hypoxanthine phosphoribosyltransferase (hprt) encoding region of man

1997 • 4 citations

Mutant Rodent Cells Defective in DNA Double-Strand Break Repair

1998 • 4 citations