Links between chromatin structure, DNA repair and chromosome fragility

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

The distribution of CpG islands in mammalian chromosomes

1994 • 254 citations

Transcription: In tune with the histones

1994 • 239 citations

RELATIONSHIPS BETWEEN DNA REPAIR AND TRANSCRIPTION

1996 • 235 citations

Histone H4 and the maintenance of genome integrity.

1995 • 168 citations

Enhanced DNA Repair Synthesis in Hyperacetylated Nucleosomes

1989 • 136 citations

Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes

1994 • 134 citations

Nuclear architecture and the induction of chromosomal aberrations

1996 • 131 citations

Histone acetylation: A possible mechanism for the inheritance of cell memory at mitosis

1997 • 121 citations

Differential underacetylation of histones H2A, H3 and H4 on the inactive X chromosome in human female cells

1996 • 106 citations

The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair

1995 • 96 citations

Conversion of excision‐repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes

1992 • 87 citations

Detection of chromosomal breakage in the 1cen-1q12 region of interphase human lymphocytes using multicolor fluorescence in situ hybridization with tandem DNA probes.

1995 • 85 citations

Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization

1996 • 74 citations

Chromatin Decondensed by Acetylation Shows an Elevated Radiation Response

1989 • 57 citations

Analysis of loss of inactive X chromosomes in interphase cells.

1996 • 53 citations

Micronuclei induction by 131I exposure: Study in hyperthyroidism patients

1997 • 53 citations

Hierarchies of DNA repair in mammalian cells: biological consequences

1991 • 49 citations

Fast repair of O ⁶ -ethylguanine, but not O ⁶ -methylguanine, in transcribed genes prevents mutation of H- ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

1998 • 45 citations

Radioactive iodine induces clastogenic and age-dependent aneugenic effects in lymphocytes of thyroid cancer patients as revealed by interphase FISH

1997 • 45 citations

Low level of DNA repair in human chromosome 1 heterochromatin

1997 • 44 citations

Chromosomes with high gene density are preferentially repaired in human cells

1997 • 42 citations

DNA Repair in Specific Sequences in Mammalian Cells

1987 • 39 citations

The origin of micronuclei induced by cytosine arabinoside and its synergistic interaction with hydroxyurea in human lymphocytes

1994 • 36 citations

Functional Nucleotide Excision Repair Is Required for the Preferential Removal of N-Ethylpurines from the Transcribed Strand of the Dihydrofolate Reductase Gene of Chinese Hamster Ovary Cells

1997 • 30 citations

Butyrate and acetyl‐carnitine inhibit the cytogenetic expression of the fragile X in vitro

1994 • 26 citations

FISH analysis of 1cen1q12 breakage, chromosome 1 numerical abnormalities and centromeric content of micronuclei in buccal cells from thyroid cancer and hyperthyroidism patients treated with radioactive iodine

1999 • 22 citations

The Use of Streptavidin-Coated Magnetic Beads and Biotinylated Antibodies to Investigate Induction and Repair of DNA Damage: Analysis of Repair Patches in Specific Sequences of uv-Irradiated Human Fibroblasts

1993 • 12 citations

Position effect of translocations involving the inactive X chromosome: physical linkage to XIC/XIST does not lead to long-range de novo inactivation in human differentiated cells

1998 • 10 citations

Radiosensitivity and repair of the inactive X-chromosome. Insights from FISH and immunocytogenetics

1998 • 10 citations

P V.13 Chromosomal distribution of genes subject to transcription coupled DNA repair

1997 • 2 citations

P X.11 Position effect of translocations involving the inactive X-chromosome. A study combining FISH and immunocyto-genetics

1997 • 1 citations