The Role of Long-Chain Fatty Acyl-CoA Esters in β-Cell Signal Transduction

Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

1980 • 1,430 citations

Fatty acids, lipotoxicity and insulin secretion

1999 • 563 citations

Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells.

1992 • 495 citations

Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

1996 • 466 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS

1992 • 314 citations

Possible role for fatty acyl-coenzyme A in intracellular protein transport

1987 • 302 citations

Pancreatic β-Cells in Obesity

1995 • 276 citations

Phosphorylation of Munc-18/n-Sec1/rbSec1 by Protein Kinase C

1996 • 262 citations

A Role for Malonyl-CoA in Glucose-Stimulated Insulin Secretion from Clonal Pancreatic β-Cells

1989 • 259 citations

Fatty acylation of proteins

1989 • 230 citations

Oligomerization of VIP21‐caveolin in vitro is stabilized by long chain fatty acylation or cholesterol

1996 • 205 citations

Are Metabolic Oscillations Responsible for Normal Oscillatory Insulin Secretion?

1997 • 195 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

More Direct Evidence for a Malonyl-CoA–Carnitine Palmitoyltransferase I Interaction as a Key Event in Pancreatic β-Cell Signaling

1994 • 172 citations

Activation of the ATP-sensitive K+ Channel by Long Chain Acyl-CoA

1996 • 167 citations

Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion

1998 • 150 citations

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.

1998 • 147 citations

Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA

1997 • 146 citations

Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets.

1995 • 140 citations

Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA

1998 • 138 citations

Evidence for an Anaplerotic/Malonyl-CoA Pathway in Pancreatic β-Cell Nutrient Signaling

1996 • 136 citations

Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues. Relationship between ligand binding and inhibition of carnitine palmitoyltransferase I

1983 • 124 citations

Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles

1995 • 114 citations

Long Chain Coenzyme A Esters Activate the Pore-forming Subunit (Kir6.2) of the ATP-regulated Potassium Channel

1998 • 108 citations

Extraction of tissue long-chain acyl-CoA esters and measurement by reverse-phase high-performance liquid chromatography

1985 • 103 citations

The stimulus-secretion coupling of glucose-induced insulin release: Fuel metabolism in islets deprived of exogenous nutrient

1983 • 99 citations

The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids

1975 • 95 citations

[9] Analysis of acyl-coenzyme A esters in biological samples

1988 • 88 citations

Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells.

1992 • 87 citations

Studies on the interaction of palmitoyl coenzyme A with the adenine nucleotide translocase.

1982 • 85 citations

Ca2+ and pancreatic B-cell function

1994 • 83 citations

Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme a esters in liver and skeletal muscle

1992 • 83 citations

Evidence for a Unique Long Chain Acyl-CoA Ester Binding Site on the ATP-regulated Potassium Channel in Mouse Pancreatic Beta Cells

1997 • 83 citations

Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?

1993 • 80 citations

Content of CoA-Esters in Perifused Rat Islets Stimulated by Glucose and Other Fuels

1991 • 79 citations

SNAREs line up in new environment

1998 • 79 citations

Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism

1986 • 72 citations

Interactions of acyl-coenzyme A with phosphatidylcholine bilayers and serum albumin

1992 • 62 citations

Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT)

1996 • 61 citations

Essential Role of Acetyl-CoA Carboxylase in the Glucose-Induced Insulin Secretion in a Pancreatic β-Cell Line

1998 • 53 citations

Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences

1995 • 51 citations

Dissociation between changes in cytoplasmic free Ca2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets.

1995 • 49 citations

Rapid Glucose-Dependent Increases in Phosphatidic Acid and Phosphoinositides in Rat Pancreatic Islets*

1986 • 44 citations

Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.

1994 • 42 citations

Cloning and expression of rat pancreatic β-cell malonyl-CoA decarboxylase

1999 • 41 citations

Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2+.

1998 • 37 citations

Cytoplasmic accumulation of a normally mitochondrial malonyl-CoA decarboxylase by the use of an alternate transcription start site

1992 • 30 citations

Carnitine effects on coenzyme A profiles in rat liver with hypoglycin inhibition of multiple dehydrogenases

1997 • 20 citations

The activity of ?-hydroxyacyl-CoA dehydrogenase in the pancreatic islets of hyperglycaemic mice

1970 • 14 citations