Generation of T-cell receptor retrogenic mice

Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’

2001 • 761 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Betaine Improves the PCR Amplification of GC-Rich DNA Sequences

1997 • 485 citations

Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.

1994 • 367 citations

E unum pluribus: multiple proteins from a self-processing polyprotein

2005 • 346 citations

Betaine can eliminate the base pair composition dependence of DNA melting

1993 • 282 citations

Development of 2A peptide-based strategies in the design of multicistronic vectors

2005 • 272 citations

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

1997 • 230 citations

Denaturants or cosolvents improve the specificity of PCR amplification of a G + C-rich DNA using genetically engineered DNA polymerases

1994 • 207 citations

The timing of TCRα expression critically influences T cell development and selection

2005 • 179 citations

Uniform amplification of a mixture of deoxyribonucleic acids with varying GC content.

1996 • 177 citations

Rapid analysis of T-cell selection in vivo using T cell–receptor retrogenic mice

2006 • 159 citations

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells

1998 • 110 citations

Polycistronic Viral Vectors

2002 • 99 citations

An Improved Method for Generating Retroviral Producer Clones for Vectors Lacking a Selectable Marker Gene

1998 • 84 citations

The CD3ε Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function

2005 • 70 citations

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

1994 • 64 citations

Diabetes Incidence Is Unaltered in Glutamate Decarboxylase 65-Specific TCR Retrogenic Nonobese Diabetic Mice: Generation by Retroviral-Mediated Stem Cell Gene Transfer

2004 • 38 citations

Positive and negative selection of the T cell repertoire in MHC class II transgenic mice.

1989 • 15 citations